N/A N=17 Radiographic Progression of Infiltrated Caries Lesions In-vivo
Dental Caries
Primary: Number of Lesions Showing Radiographic Progression as Measured by Lesion Size (Continuous) — 2; 11 Lesions — p=0.002
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=42 Resin Infiltration to Arrest Early Tooth Decay
Dental Caries
Primary: Number of Lesions With Progression as Measured by Pairwise (PW) Comparison (N=Lesions) — 4; 14 Lesions — p==0.003
N/A N=80 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Caries Infiltration · Fluorosis · Dental Care
Primary: Esthetic Changes — 1.90; 5.50; 5.53; 5.35 score on a scale
N/A N=120 Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser
Dental Caries
Primary: International Caries Detection and Assessment System (ICDAS II) - Number of Molars With ICDAS Score of 3 or More - ICDAS Score 3, Cavity - — 0; 13 right or left second…
Phase 3 N=65 In Situ Caries Model of Fluoride Toothpastes
Caries
Primary: Percent Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to NaF Toothpaste (1426ppmF) and AmF Toothpaste (1400ppmF) — 38.05; 41.06 Percentage SMHR…
Phase 3 N=44 Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique
Dental Caries
Primary: Bacterial Count of Streptococus Mutans — 2.00; 2.04; 1.12; 1.05 CFU/ml log10
Phase 2 N=70 Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Dental Caries
Primary: Caries Activity and Progression Assessment Using LASER Fluorescence Readings by Diagnodent® Device. — 18.6; 1.1 units on a scale
Phase 3 N=394 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Dental Caries
Primary: ICDAS Severity Value — 17; 22; 278; 273 teeth — p=0.1126
Phase 3 N=60 In Situ Caries of Fluoride Toothpastes
Healthy Subjects · Partial Denture Wearers · Caries
Primary: Mean Percentage Surface Microhardness Recovery (%SMHR) of Enamel Specimens Exposed to NaF/Carbopol Toothpaste (1400 ppmF), NaF Toothpaste (1350ppmF) Compared to…
Phase 3 N=57 In Situ Caries Efficacy of Fluoride Toothpastes
Caries
Primary: Percentage Surface Microhardness Recovery (%SMHR) of Sound Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and NaF Toothpaste (1400ppmF) — 28.31; 26.32 Percentage…
Phase 2 N=345 Non-invasive Treatment of Root Caries in Older Adults
Root Caries
Primary: Root Caries Activity — 3.72; 40.52 Percentage of active lesions (2-years)
N/A N=50 Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Dental Caries · Denture, Partial, Removable
Primary: Mineral Loss ΔZ — 235; 774 vol% * μm]
N/A N=35 Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection
Dental Caries
Primary: Caries Extension According to Diagnocam Codes 0-4 (Intra- and Interrater-Reliability, Sensitivity and Specificity) — 0.68; 0.87; 0.62; 0.76 weighted Kappa
N/A N=51 Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
Dental Caries in Children · Dental Caries Class II · Dental Caries
Primary: Interproximal Caries Zone of Radiolucency — 9; 7; 10; 12 Number of teeth
N/A N=45 Efficacy of Three Toothpastes Using an in Situ Caries Model
Dental Caries
Primary: Percentage Surface Microhardness Recovery (SMHR) of Phyte (0% 0.425% and 0.85%) at 2 Weeks — 25.53; 26.81; 7.41; 28.88 % SMHR — p=0.7603
N/A N=57 Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar Incisor Hypomineralization · Dental Caries · Hypomineralization of Enamel
Primary: Clinical Outcome Based on Success After Intervention on MIH Affected Molar at 6 Months — 17; 18; 17 number of Successful MIH affected molars
Phase 4 N=40 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
Dental White Spots · Dental Caries
Primary: Change in White Spot Lesions Count - Enamel Decalcification Index (EDI) — 40.2; 41.3 units on a scale
Phase 3 N=983 Prevention of Adult Caries Study (PACS)
Caries, Dental
Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…
N/A N=62 The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ
Oral Hygiene
Primary: Percentage Surface Microhardness Recovery (% SMHR) — 32.49; 31.81; 27.56; 22.62 Percentage of SMHR — p=<0.0001
Phase 4 N=83 Enamel Remineralization Potential of Dentifrices in Situ
Dental Caries
Primary: Percentage Surface Microhardness Recovery (%SMHR) of Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and SnF/NaF Toothpaste (1450ppmF) — 40.94; 17.88 Percentage of…
Phase 2 N=20 Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
Dental Erosion
Primary: Percentage Surface Micro-hardness Recovery (SMHR) of Enamel Specimens — 39.46; 38.31; 36.17; 17.26 % SMHR — p=0.7756
N/A N=3,345 Comparative Effectiveness of Treatments to Prevent Dental Caries
Dental Caries
Primary: Number of Participants With Arrested Dental Caries, Assessed Using a Clinical Oral Examination — 48; 53 Participants
N/A N=86 Clinical Evaluation of an Experimental Remineralization Product
White Spot Lesion
Primary: White Spot Measurement — 34; 37; 1; 0 Lesions
N/A N=7,418 Comparative Effectiveness of School-based Caries Prevention
Dental Caries · Quality of Life
Primary: Proportion of Subjects With All Caries Arrested — 108; 101 Participants
N/A N=36 In Vivo Assessment of the Tooth-Resin Composite Interface Using Optical Coherence Tomography
Cavity · Cavities of Teeth
Primary: Marginal Staining: World Dental Federation (FDI) Criteria - Baseline — 18; 18; 0; 0 Participants
N/A N=150 Caries Prevention Effect of S-PRG Filler Incorporated in Denture Base Resins on Edentulous Elderly People
Dental Caries
Primary: Saliva Fluoride Concentration (Part Per Million,Ppm) — 0.05; 0.05; 0.09; 0.22 part per million,ppm — p=<0.05
N/A N=169 European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth
Dental Caries
Primary: Failure Rate of the Three Treatment Arms Judged Clinically — 37; 31; 39; 2 Teeth — p=0.02
N/A N=30 Caries Lesion Activity in Orthodontic Patients - Calcivis System
Dental Caries
Primary: Presence or Absence of Elevated Luminescence — 61.7; 17.3; 6.0; 10.2 % active teeth with luminescence
Phase 4 N=20 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions
Caries
Primary: Change in Bacterial Composition Before and One Month After SDF Application to Root or Cervical Caries Lesions — 1890087; 1959306 bacterial count
Phase 3 N=98 Effectiveness of Silver Diamine Fluoride as a Treatment for Caries in Comparison to Traditional Restorative Techniques
Caries
Primary: Caries Arrest of Teeth in the SDF Group Measured by Change in Size — 10 Participants