N/A N=17 Radiographic Progression of Infiltrated Caries Lesions In-vivo
Dental Caries
Primary: Number of Lesions Showing Radiographic Progression as Measured by Lesion Size (Continuous) — 2; 11 Lesions — p=0.002
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=30 Caries Lesion Activity in Orthodontic Patients - Calcivis System
Dental Caries
Primary: Presence or Absence of Elevated Luminescence — 61.7; 17.3; 6.0; 10.2 % active teeth with luminescence
Phase 3 N=983 Prevention of Adult Caries Study (PACS)
Caries, Dental
Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…
N/A N=70 RCT of Pulp Capping Over Carious Exposure in Adults
Carious Exposure · Human Permanent First and Second Molars · Mature Teeth
Primary: Survival of Capped Pulps — 842; 1201 Survival days — p=<0.01
N/A N=42 Post-Approval Clinical Study to Evaluate the Calcivis Caries Activity Imaging System
Dental Caries
Primary: Percentage Agreement of Sound/Unsound Teeth Between ICDAS Score and Calcivis System — 72.3 percentage agreement — p=<0.001
Phase 3 N=65 In Situ Caries Model of Fluoride Toothpastes
Caries
Primary: Percent Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to NaF Toothpaste (1426ppmF) and AmF Toothpaste (1400ppmF) — 38.05; 41.06 Percentage SMHR…
Phase 4 N=40 MI Varnish and MI Paste Plus in a Caries Prevention and Remineralization Study
Dental White Spots · Dental Caries
Primary: Change in White Spot Lesions Count - Enamel Decalcification Index (EDI) — 40.2; 41.3 units on a scale
Phase 3 N=169 Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Caries · Dental Pulp Exposure
Primary: Parameters Evaluated After Treatment — 19; 19; 25; 3 Participants
N/A N=86 Clinical Evaluation of an Experimental Remineralization Product
White Spot Lesion
Primary: White Spot Measurement — 34; 37; 1; 0 Lesions
Phase 2 N=70 Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Dental Caries
Primary: Caries Activity and Progression Assessment Using LASER Fluorescence Readings by Diagnodent® Device. — 18.6; 1.1 units on a scale
N/A N=110 Safety and Performance Evaluation of the Calcivis System
Dental Caries
Primary: Number of Teeth Identified as Sound or Unsound by the Calcivis System That Were in Agreement With the Dentist's Assessment — 88; 78 teeth — p=<0.0001
N/A N=45 Efficacy of Three Toothpastes Using an in Situ Caries Model
Dental Caries
Primary: Percentage Surface Microhardness Recovery (SMHR) of Phyte (0% 0.425% and 0.85%) at 2 Weeks — 25.53; 26.81; 7.41; 28.88 % SMHR — p=0.7603
N/A N=98 Clinical Comparison of Vital Pulp Capping Restorative Protocols
Deep Dental Caries
Primary: Success Rate Based on Pulp Vitality Tests (Vital/Non Vital) — 96.2; 100; 100; 86 Percentage of success rate — p=>0.1
Phase 2 N=345 Non-invasive Treatment of Root Caries in Older Adults
Root Caries
Primary: Root Caries Activity — 3.72; 40.52 Percentage of active lesions (2-years)
N/A N=32 Conventional Bite Wing Radiography Versus Stationary Intraoral Tomosynthesis, a Comparison Study
Dental Caries
Primary: ROC Using the Area Under the Curve (AUC) — 0.5427; 0.5173 probability
Phase 3 N=44 Antibacterial Effect of Nano Silver Fluoride vs Chlorhexidine on Occlusal Carious Molars Treated With Partial Caries Removal Technique
Dental Caries
Primary: Bacterial Count of Streptococus Mutans — 2.00; 2.04; 1.12; 1.05 CFU/ml log10
Phase 3 N=394 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Dental Caries
Primary: ICDAS Severity Value — 17; 22; 278; 273 teeth — p=0.1126
Phase 3 N=323 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults
Dental Caries
Primary: Number of New Tooth Root Caries Lesions — 1.1; 0.43; 0.56 new carious root surfaces
N/A N=35 Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection
Dental Caries
Primary: Caries Extension According to Diagnocam Codes 0-4 (Intra- and Interrater-Reliability, Sensitivity and Specificity) — 0.68; 0.87; 0.62; 0.76 weighted Kappa
Phase 3 N=57 In Situ Caries Efficacy of Fluoride Toothpastes
Caries
Primary: Percentage Surface Microhardness Recovery (%SMHR) of Sound Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and NaF Toothpaste (1400ppmF) — 28.31; 26.32 Percentage…
Phase 2 N=20 Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
Dental Erosion
Primary: Percentage Surface Micro-hardness Recovery (SMHR) of Enamel Specimens — 39.46; 38.31; 36.17; 17.26 % SMHR — p=0.7756
Phase 2 N=296 Effect of CPP-ACP Paste on Dental Caries in Primary Teeth
Dental Caries
Primary: the Mean Number of Enamel Carious Lesion — 13.69; 14.55 Surfaces
N/A N=50 Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Dental Caries · Denture, Partial, Removable
Primary: Mineral Loss ΔZ — 235; 774 vol% * μm]
N/A N=36 In Vivo Assessment of the Tooth-Resin Composite Interface Using Optical Coherence Tomography
Cavity · Cavities of Teeth
Primary: Marginal Staining: World Dental Federation (FDI) Criteria - Baseline — 18; 18; 0; 0 Participants
Phase 3 N=55 A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model
Dental Caries
Primary: Percentage Surface Microhardness Recovery of Test Dentifrices Relative to Placebo Dentifrice — 30.72; 29.49; 28.29; 25.13 %SMHR — p=<0.0001
Phase 2 N=274 Efficacy and Safety Evaluation of Anti-Caries Varnish
Dental Caries in Children
Primary: Caries Increment — 9.8; 11.3 Number of tooth surfaces — p=0.279
N/A N=120 Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser
Dental Caries
Primary: International Caries Detection and Assessment System (ICDAS II) - Number of Molars With ICDAS Score of 3 or More - ICDAS Score 3, Cavity - — 0; 13 right or left second…
N/A N=7,418 Comparative Effectiveness of School-based Caries Prevention
Dental Caries · Quality of Life
Primary: Proportion of Subjects With All Caries Arrested — 108; 101 Participants
N/A N=169 European Study on Three Different Approaches to Managing Class 2 Cavities in Primary Teeth
Dental Caries
Primary: Failure Rate of the Three Treatment Arms Judged Clinically — 37; 31; 39; 2 Teeth — p=0.02
N/A N=3,345 Comparative Effectiveness of Treatments to Prevent Dental Caries
Dental Caries
Primary: Number of Participants With Arrested Dental Caries, Assessed Using a Clinical Oral Examination — 48; 53 Participants