N/A N=20 Brain Stimulation and Hand Training in Children With Hemiparesis
Pediatric Hemiparesis
Primary: Change in Assisting Hand Assessment (AHA) — 6.4; 8; 5.5; 7.6 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=15 Contralaterally Controlled FES for Hand Opening in Hemiplegic Cerebral Palsy
Cerebral Palsy
Primary: Change in Assisting Hands Assessment Logit Score at End of Treatment — 2.63; 4.33 Scores on a scale
N/A N=32 Therapeutic Effects of Constraint-Induced Movement Therapy on Young Children With Cerebral Palsy
Cerebral Palsy Spastic Hemiplegic
Primary: Change From Baseline Pediatric Motor Activity Log (PMAL) Score at Post Test — 0.83; 0.00; 0.50; -0.05 score on a scale
N/A N=44 A Pilot Study of Hand Function in Children With Cerebral Palsy Undergoing Intensive Neurophysiological Rehabilitation
Cerebral Palsy
Primary: Jebsen Taylor Hand Function Test for Dominant Hand — 130.1; 115.2 seconds
N/A N=44 Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy
Cerebral Palsy · Hemiplegia · Children
Primary: Change in Score on Assisting Hand Assessment (AHA) — 0.42; 0.56 score — p=<0.01
N/A N=27 Effects of Pediatric Aquatic Therapy in Children With Spastic Cerebral Palsy
Spastic Cerebral Palsy
Primary: Unit on Gross Motor Function Measure Scale (GMFM) — 5.12; 2.00 units on a scale — p=0.007
N/A N=15 Use of Joystick-operated Ride-on-toys to Improve Affected Arm Use and Function in Children With Hemiplegic Cerebral Palsy
Hemiplegic Cerebral Palsy
Primary: Change in Affected Arm Movement Control — 74.9; 78.3; 83.8 percentage
N/A N=6 Use of Low Cost Prostheses to Improve Upper Extremity Function in Children With Cerebral Palsy
Cerebral Palsy · Prosthesis User
Primary: Number of Participants With Clinically Significant Increase in Assisting Hand Assessment (AHA) Score — 4 Participants
N/A N=49 Progressive Supervised Home-based Strength Training in Children With Spastic Cerebral Palsy
Cerebral Palsy, Spastic
Primary: Change in Muscle Size Parameter — 3.7; 1.6; 1.4; 0.1 milliliters — p=<0.01
N/A N=32 Dynamic Gait Index in Hemiplegic Cerebral Palsy
Cerebral Palsy · Hemiplegic Cerebral Palsy · Gait Disorders, Neurologic
Primary: Dynamic Gait Index (DGI) — 19; 24; 18.5 units on a scale — p=<0.01
N/A N=9 Therapeutic Dance Intervention for Children With Cerebral Palsy
Cerebral Palsy
Primary: Congruent Trial (Hearts) Accuracy — 87.96; 87.50 percentage of correct
N/A N=55 Quantifying Patient-Specific Changes in Neuromuscular Control in Cerebral Palsy
Cerebral Palsy
Primary: Change in Walk Dynamic Motor Control Index 6-months After Orthopaedic Surgery — -2.4 normalized z-score
N/A N=6 Robotic-assisted Therapy to Improve Manual Dexterity in Children With Cerebral Palsy
Cerebral Palsy
Primary: Change in Quality of Upper Extremity Skills Test (QUEST) Score - Section on Dissociated Movements — 3.5 units on a scale
Phase 1 N=11 Safety and Tolerability of Dalfampridine in Subjects With Cerebral Palsy
Cerebral Palsy (CP)
Primary: Safety and Tolerability of Dalfampridine-ER 10mg in Subjects With Cerebral Palsy (CP) — 1; 2; 6; 9 participants
N/A N=20 Single-session tDCS in Cerebral Palsy
Cerebral Palsy · Perinatal Stroke · Periventricular Leukomalacia
Primary: Change in Motor Evoked Potential Amplitude — 12.4; 81.7; -34.4 percent change
Phase 3 N=351 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy
Cerebral Palsy · Spasticity
Primary: MP: Change From Baseline in Ashworth Scale (AS) in UL Primary Clinical Target Pattern at Week 4 — -0.93; -1.15; -0.96; -1.02 Unit on a scale — p== 0.017
N/A N=20 Perinatal Stroke: Understanding Brain Reorganization
Stroke · Hemiparesis
Primary: Cortical Excitability MEP Amplitude (µV) — 325 µV
N/A N=10 Precision Gait Retraining for Children With Cerebral Palsy
Cerebral Palsy · Gait Disorders, Neurologic
Primary: Gait Metric Accuracy — 2.01 percentage of error
Phase 3 N=311 Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Leg(s) in Cerebral Palsy
Lower Limb Spasticity Due to Cerebral Palsy
Primary: Change From Baseline in the Ashworth Scale (AS) Score of Plantar Flexors of the Primary Body Side at Day 29 (Week 4) of the First Injection Cycle (1st IC) — -0.7; -0.66…
Phase 3 N=212 Efficacy And Safety Of Dysport In The Treatment Of Upper Limb Spasticity In Children
Upper Limb Spasticity (Altered Skeletal Muscle Performance) in Children
Primary: Mean Change From Baseline to TC 1, Week 6 in MAS Score in the TC 1 PTMG — -1.5; -1.9; -2.2 score on a scale — p=0.0118
N/A N=12 Cerebral Palsy: Short-burst Interval Training
Cerebral Palsy Spastic Diplegia
Primary: Change in Walking Performance High Versus Low Frequency SBLTT Groups — 1872; 1551 strides per day — p=.39
Phase 3 N=370 Long-term Open-label Study of Botulinumtoxin Type A to Treat Spasticity of Leg(s) or Leg(s) and Arm in Cerebral Palsy
Lower Limb and Combined Lower Limb and Upper Limb Spasticity Due to Cerebral Palsy
Primary: Occurrence of Treatment Emergent Adverse Events (TEAEs) Overall and Per Injection Cycle — 53; 44; 26; 31 participants
N/A N=83 Intensive Unimanual (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegia
Cerebral Palsy · Hemiplegia · Children
Primary: Jebsen-Taylor Test of Hand Function — 323.6; 479.5; 265.6; 121.3 seconds
N/A N=10 Pediatric Teleneuromodulation
Cerebral Palsy (CP)
Primary: Status/Safety Assessment — 4; 7; 20; 12 number of sessions symptom reported
Phase 3 N=63 A Study of TEV-50717 (Deutetrabenazine) for the Treatment of Dyskinesia in Cerebral Palsy in Children and Adolescents
Cerebral Palsy, Dyskinetic
Primary: Change From Baseline in the Movement Disorder-Childhood Rating Scale (MD-CRS) Part II Total Score (Movement Disorder Severity, Centrally Read) at Week 15 — -0.4; -1.5…
N/A N=19 Muscle Synergies During Gait in Children With Cerebral Palsy Undergoing Robot-assisted Gait Therapy
Cerebral Palsy
Primary: Change in Cosine Similarity of the Muscle Synergies of the Most Affected Lower Limb — 2 percentage of muscle synergies
Phase 2 N=63 A Randomized Study of Autologous Umbilical Cord Blood Reinfusion in Children With Cerebral Palsy
Cerebral Palsy · CP · Spastic Cerebral Palsy
Primary: Change in Gross Motor Function Measure 66 (GMFM-66) Score — 7.5; 6.9 units on a scale — p=0.72
Phase 3 N=12 Effect of Dysport Injections on Energy Expenditure and Walking Efficiency in Children With Cerebral Palsy
Cerebral Palsy
Primary: Oxygen Consumption (ml/kg/Min) — 14.82; 16.75; 28.77 ml/kg/min
N/A N=47 Effects of Hippotherapy on Physical Fitness and Attention in Cerebral Palsy
Cerebral Palsy · Physical Activity · Attention Disorder
Primary: Change of Clinical Global Improvement(CGI) — -0.13; -0.09; 2.65; 3.87 score on a scale
N/A N=41 Cerebral Palsy Early Mobility Training
Cerebral Palsy
Primary: Change in Gross Motor Function Measure (GMFM-66) During Treatment Phase — 2.2; 3.5 units on a scale