Clinical Trial Search

Primary: Mean % Change From Baseline in Trabecular Number (Tb.N) by HR-pQCT — 2.1; -0.6; 0.9; 4.1 Percent change

Primary: Percent Change in Bone Mineral Density (BMD) of Lumbar Spine and Hips — 2.7; 3.0; 2.3; 1.9 percent change — p=<0.0001

Primary: Change From Baseline in Bone Mineral Density (BMD) Measured by Dual-Energy X-ray Absorptiometry (DXA) — -0.0026; 0.1299; 0.1196; -0.0029 gram per centimeter squared…

Primary: Lumbar Spine Bone Mineral Density Percent Change From Baseline at Month 12 for the Placebo and Denosumab Arms — -0.81; 4.41; 4.71; 6.69 Percent change — p=<0.001

Primary: Change From Baseline to 52 Week Endpoint in Lumbar Spine Bone Mineral Density (BMD) — 0.065; 0.115; 0.142; 0.054 g/cm^2

Primary: Percent Change From Baseline in Total Hip Bone Mineral Density (BMD) at Week 48 — 1.34; 0.05 Percent change — p=0.014

Primary: Total Hip Bone Mineral Density Percent Change From Baseline at Month 12 — 2.6; 3.5 Percent Change from Baseline — p=<0.0001

Primary: Percent Change From Baseline at Month 12 in BMD at the Lumbar Spine — -0.1; 4.1; 7.1; 5.4 percent change — p=< 0.0001

Primary: Change in Distal Tibia Bone Quality — 1.121; -2.141 percentage of change — p=0.0481

Primary: Guideline Concordant Osteoporosis Therapy — 2537; 2477 Participants

Primary: Postero-anterior (PA) Lumbar Spine Bone Mineral Density by Dual-energy X-ray Absorptiometry (DXA) — 0.90; 0.87 g/cm^2 — p=0.009

Primary: Sensitivity of the Density Index Against Dual Energy X-ray Absorptiometry for Detecting Osteoporosis — 93.7; 100 percentage of true positives

Primary: Proportion of Change in Mean Trabecular Bone Score — .00238 Proportion of change

Primary: Change in Bone Mineral Density (BMD) From Baseline to 1 Year — 0.048; 0.007; 0.014; 0.005 grams per cubic centimeter

Primary: BMD at Left Total Hip — 0.02 % change in BMD (gm/cm2) from baseline

Primary: Percentage of Participants With Modeling Based Bone Formation in the Femoral Neck — 100 percentage of participants

Primary: Total Hip Bone Mineral Density (BMD) at Baseline, 6 and 12 Months After Hip Fracture. — -0.008; 0.005; -0.017; -0.012 g/cm^2 — p=0.05

Primary: Change in Bone Mineral Density (BMD) in HIP at 6 Months — -0.041; 0.011 grams/cm^2

Primary: Thyroid Extreme CT — 0.89; 1.16 mm

Primary: C-telopeptide of Type I Collagen (CTX) Change — 0.09; 0.08 ng/mL

Primary: Percent Change From Baseline to Weeks 24 and 48 in Lumbar Spine BMD — 14.4; 5.5; 15.9; 7.1 Percent change from baseline — p=<0.001

Primary: Baseline Total Volumetric Bone Density at the Femur 4% Site — 277.25; 270.79 milligrams per cubic centimeter (mg/ccm)

Primary: Percent Change in Number of Osteoblast and Adipocyte Colony Forming Units Cultured From Bone Marrow Stem Cells Harvested 6 Months After Treatment With Study Drug…

Primary: Change in Bone Density Over a 12-month Period — 0.045; 0.280 score on a scale — p=.109

Primary: Change in Hip Bone Mineral Density (BMD) — 0; -.03 g/cm2

Primary: Change in Bone Mineral Density — 1072; 1295 number of pixels with change

Primary: Percent Change From Baseline in Mammographic Breast Density at Month 24 — -0.39; -0.05; -0.23; -0.42 percent change

Primary: Changes in BMD at Femoral Neck — -3.2; 0.25 percentage of change in BMD — p=<0.05

Primary: Percent Change From Baseline in Bone Mineral Density (BMD) at the Lumbar Spine — 2.13; 2.08 percent change — p=0.002

Primary: Least Squares Mean Percent Change From Baseline To Month 12 in Lumbar Spine Areal Bone Mineral Density (BMD) — -0.36; -0.67; -0.52; -0.53 percent change — p=0.012