Phase 2 N=21 Metoclopramide for Post-Traumatic Headache. A Pilot Study
Post-Traumatic Headache
Primary: Number of Participants With Sustained Headache Relief — 12 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=40 Sumatriptan as Treatment for Post-traumatic Headache
Post-traumatic Headache
Primary: Change in Headache Relief — 23 percentage of headaches resolved — p=.079
Phase 3 N=160 Metoclopramide for Post Traumatic Headache
Post-Traumatic Headache
Primary: 0-10 Pain Scale on Which 0 = no Pain and 10= the Worst Pain Imaginable — 5.2; 3.8 units on a scale
Phase 1 N=9 TMS and Exercise for Post-stroke Pain
Chronic Post-stroke Headache
Primary: Change in Modified Rankin Scale From Baseline to Follow-up 30 Days After Last Intervention — 0; 1 units on a scale — p=0.896
N/A N=45 Do Patients With Chronic Daily Headache Have Continuous Headache or Moments of Headache Relief?
Chronic Daily Headache
Primary: Number of Subjects With Daily Headache Who Have Continuous Headache — 18; 27 participants
Phase 2 N=89 Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin
Posttraumatic Headache · Combat Disorders · Post Concussion Syndrome
Primary: Headache Diary — -10.7; -6.9 headaches per month — p=0.034
N/A N=459 A Retrospective Chart Review to Evaluate Diagnosis and Treatment of Chronic Migraine and Headache
Migraine Disorders · Headache
Primary: Presence or Absence of Prophylactic Medication for Headache/Migraine — 166; 227; 18; 48 Participants
N/A N=193 Cognitive-Behavior Therapy for Posttraumatic Headache
Post-traumatic Headache · PTSD
Primary: Headache-related Disability Scores on the Headache Impact Test 6 (HIT-6) — 66.1; 66.1; 65.2; 61.9 score on a scale — p=<0.001
Phase 4 N=89 Prazosin for Post-Concussive Headaches
Post-Traumatic Headache
Primary: Change From Baseline in Headache Frequency — 16.4; 18.5; -9.2; -7.4 headaches per month
N/A N=309 Prospective ED Headache Cohort Study
Headache
Primary: Number of Participants Who Report Moderate or Severe Pain Within 24 Hours of Emergency Department(ED) Discharge — 53; 6; 20 Participants
Phase 4 N=162 Dexamethasone for Post Traumatic Headache
Post-Traumatic Headache
Primary: Frequency of Moderate or Severe Headache After Emergency Department (ED) Discharge — 31; 29; 42; 44 Participants — p=0.751
N/A N=60 Medication-overuse Headache: 4 Years Follow up
Medication Overuse Headache
Primary: Change in Headache Days/Month After 4 Years Compared to Baseline — 6.6 headache days/month
N/A N=102 A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache.
Cluster Headache
Primary: Comparison of the Headache Pain Free Attack Rates at 15 Minutes Following the Treatment — 495; 400; 67; 46 Number of attacks
Phase 2 N=50 Amitriptyline to Prevent Headache After Traumatic Brain Injury
Brain Injuries · Post-Traumatic Headache
Primary: Frequency of Headaches — 10 Participants — p=.101
Early Phase 1 N=26 The Effectiveness of Osteopathic Manipulative Medicine in the Management of Headaches Associated With Post Concussion Syndrome
Headache · Post-Concussion Syndrome
Primary: Immediate Change in Headache Scores With a Visual Analog Scale (VAS) — 5.6; NA; 3.5; NA units on a scale
N/A N=26 Remotely Supervised tDCS for Persistent Post-traumatic Headache
Persistent Post Traumatic Headache · Mild Traumatic Brain Injury
Primary: Change From Baseline in the Number of Moderate-to-Severe Headache Days Per Month — -2.5; 2.3; -3.9; 1.2 Days per Month
N/A N=79 Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Traumatic Brain Injury (TBI)
Primary: Number of Headache Days Per Week — 4.2; 4.6; 3.1; 4.3 days/week — p=<0.000
N/A N=29 Improving Functions in MTBI Patients With Headache by rTMS
TBI (Traumatic Brain Injury)
Primary: Percent Change in Composite Score of Debilitating Headache (Intensity x Duration x Frequency) — -55.3; -1.7; -58.4; -10 percent change from baseline — p=<0.0001
Phase 2 N=87 A Study to Test if Fremanezumab Reduces Headache in Participants With Posttraumatic Headache (PTH)
Post-Traumatic Headache
Primary: DB Period: Mean Change From Baseline in Monthly Average Number of Headache Days of at Least Moderate Severity During the 12-Week Treatment Period After the First Dose of…
N/A N=40 Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache
Chronic Daily Headache
Primary: Reduction in Headache Intensity — 6; 4; 1; 3 Participants
N/A N=38 Acupuncture in Traumatic Brain Injury
Chronic Post-traumatic Headache · Mild Traumatic Brain Injury
Primary: Change in Number of Headache Days — -8; -6 headache days
Phase 4 N=40 Ticagrelor Therapy for RefrACTORy Migraine Study
Migraine · Headache · Migraine Headache
Primary: Total Number of Responders — 17 Participants
N/A N=641 An Observational Study of BOTOX® as Headache Prophylaxis for Chronic Migraine
Migraine Disorders
Primary: Percentage of Participants Admitted to the Hospital for Headache — 6.0; 2.1 percentage of participants
N/A N=90 pLatelEts And MigRaine iN patEnt foRamen Ovale
Platelet Aggregation, Spontaneous · Migraine With Aura · Patent Foramen Ovale
Primary: Change in Migraine Characteristics — 43; 2; 17 Participants
Phase 4 N=50 Trial of Comprehensive Migraine Intervention
Migraine
Primary: Migraine Functional Impairment as Measured by Score on the Headache Impact Test 6 (HIT6) Scale — 59; 56 units on a scale
N/A N=494 Postoperative Headache in Elective Surgery Patients
Drug Withdrawal Headache
Primary: Frequency of Postoperative Headache in Elective Surgery Patients — 126; 37; 89 participants
Phase 4 N=16 Gabapentin for Headache in Aneurysmal Subarachnoid Hemorrhage
Aneurysmal Subarachnoid Hemorrhage
Primary: Average Numeric Pain Score — 5.2; 5.8 score on a scale — p=0.7
Phase 2 N=8 Poststroke Depression in Hemorrhagic Stroke
Stroke Hemorrhagic · Depression
Primary: Depression — 12.33; 6 units on a scale
N/A N=30 Mindfulness Based Stress Reduction and Post-Stroke Cognition
Stroke · Stroke Sequelae · Depression
Primary: Change in Cognition as Assessed by the Montreal Cognitive Assessment Score — 23.5; 22.5; 25.5; 23.7 score on a scale
Phase 3 N=205 Headache in the Emergency Department (ED) - A Multi-Center Research Network to Optimize the ED Treatment of Migraines
Migraine
Primary: Persistent Headache Pain Free at 24 Hours — 26; 19 Participants