N/A N=24 Traumatic Brain Injury and Risk for Chronic Traumatic Encephalopathy
CTE · TBI (Traumatic Brain Injury)
Primary: Distribution Volume Ratio (DVR) — 1.30; 1.39; 1.26; 1.34 Distribution Volume Ratio (DVR) — p=<0.02
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=33 rTMS to Improve Cognitive Function in TBI
Traumatic Brain Injury
Primary: Trail Making Test Part B — 52.1; 45.3; 52.9; 50.8 T-score
N/A N=55 Cognitive-Behavioral Therapy for Veterans With TBI
Insomnia · Traumatic Brain Injury
Primary: Change in Insomnia Severity — 8.833; 7.810; 9.625; 8.364 score on a scale
N/A N=6 Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
TBI (Traumatic Brain Injury)
Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time
N/A N=40 Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Traumatic Brain Injury · Post Concussive Symptoms · Depression
Primary: Examiner Score — 0.617; 0.907; 0.865; 1.155 score on a scale
N/A N=23 Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Traumatic Brain Injury · Dementia Alzheimers · Military Activity
Primary: Change in Executive Functioning as Assessed by the Trail Making Test — -9.2; 24.7 change in seconds — p=.323
N/A N=120 Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Mild Traumatic Brain Injury · Concussion
Primary: The Feasibility of Inpatient Bedside Neurocognitive Testing of Pediatric Patients With Minor Traumatic Brain Injury. — 120 participants
N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
N/A N=32 Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Concussion, Mild · Post-Concussion Symptoms · Sleep Problems
Primary: Performance on Multiple Sleep Latency Test (MSLT) — 6.67; 7.32; 6.73; 7.88 minutes
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
N/A N=79 Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Traumatic Brain Injury (TBI)
Primary: Number of Headache Days Per Week — 4.2; 4.6; 3.1; 4.3 days/week — p=<0.000
N/A N=53 LED Therapy for the Treatment of Concussive Brain Injury
Brain Concussion
Primary: Mean Difference in Change in Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) Score at Baseline and 6 Weeks. — -0.9; -5.78; 3.52; -7.26 Units on a scale
Phase 2 N=30 Tau Imaging of Chronic Traumatic Encephalopathy
Chronic Traumatic Encephalopathy
Primary: Tau Protein Uptake.. — 1.1871; 1.1652; 1.5910 SUVr
N/A N=38 Acupuncture in Traumatic Brain Injury
Chronic Post-traumatic Headache · Mild Traumatic Brain Injury
Primary: Change in Number of Headache Days — -8; -6 headache days
Phase 2 N=50 Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
Brain Injury, Chronic
Primary: Computer Cognitive Test Scores - ImPACT Verbal Memory — 70.48; 74.21; 78.12; 75.36 units on a scale
Phase 2 N=19 CDP-Choline and Working Memory After TBI: A Neuroimaging Study
Brain Injuries
Primary: Cognitive Composite Score for Group of Subjects With TBI and Healthy Controls Matched by Age, Education, and Treatment Group. — 42.750; 50.500; 49.500; 55.000 T-score…
N/A N=50 Enhanced Problem-Solving Training
Brain Concussion
Primary: Brief Symptom Inventory-18 (BSI-18) Global Severity Index T-Score — 64.21; 65.26; 66.8; 61.35 units on a scale — p=.04
N/A N=110 Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury
Insomnia · Traumatic Brain Injury
Primary: Insomnia Severity Index (ISI) — -9.7; -4.72 Units on a scale
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
N/A N=108 Brain Training to Enhance Frontal Lobe Reasoning
Traumatic Brain Injury
Primary: Glasgow Outcome Scale-Extended — 6.21; 6.30 units on a scale
N/A N=5 Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)
Traumatic Brain Injury · Word Finding Difficulty · Acquired Brain Injury
Primary: The Controlled Oral Word Association Test — 30.67; 30.5; 33.33; 35 Total items
N/A N=66 Transcranial Electrical Stimulation for mTBI
Mild Traumatic Brain Injury (mTBI) · Post-traumatic Stress Disorder
Primary: Change in Abnormal Magnetoencephalography (MEG) Slow-Waves (1-4 Hz) Activity — 1.8; 0.2; 0 units on a scale — p=0.01
Phase 2 N=79 Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)
Post-concussive Symptoms · Traumatic Brain Injury
Primary: Post-Intervation Post-concussion Symptom Scores Using RPQ - Intent to Treat — 3.5; 5.1; 4.2; 3.5 units on a scale
N/A N=22 Treatment and Recovery Monitoring of Post TBI Symptoms
Brain Injuries, Traumatic
Primary: Change From Baseline in RPQ Score at Post-treatment Sessions — -4.6; -3.4 units on a scale
Phase 2 N=18 Hyperbaric Treatment of Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Number of Participants With Improved Cerebral Perfusion — 8 Participants
N/A N=105 Mindfulness-Based Cognitive Therapy Intervention to Treat Depression in Individuals With a Traumatic Brain Injury
Depression · Traumatic Brain Injury
Primary: Beck Depression Inventory - II — 25.47; 27.13; 18.84; 25.00 units on a scale
N/A N=68 Light Therapy for Moderate Traumatic Brain Injury
Moderate Traumatic Brain Injury (TBI)
Primary: Safety and Feasibility of Applying Light Therapy After Moderate TBI — 24; 19 Participants
Phase 3 N=34 Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Depression & Other Neuropsychiatric Symptoms After Traumatic Brain Injury (TBI)
TBI Depression
Primary: Average Depression Score Using the Hamilton Depression (HAM-D) 17 Scale — 23.154; 23.076; 13.154; 12.706 units on a scale
N/A N=30 Adjunctive Pregnenolone in Veterans With Mild TBI
Traumatic Brain Injury
Primary: Brief Assessment of Cognition in Affective Disorders (BAC-A) — 0.61; 0.80 units on a scale
N/A N=98 Study of PTSD in Military Veterans Who Have Suffered Traumatic Brain Injuries
PTSD · TBI
Primary: Change in Diagnostic and Statistical Manual of Mental Disorders IV Clinician-Administered PTSD Scale DSM IV-(CAPS) — 73.13 units on a scale