Phase 2 N=7 Double-Blind Naltrexone in Compulsive Sexual Behavior
Compulsive Sexual Behavior
Primary: Yale Brown Obsessive Compulsive Scale Modified for Compulsive Sexual Behavior (YBOCS) — 8; 9.33 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=13 Tx for Child Sexual Behavior Problems
Sexual Behavior
Primary: Child Sexual Behavior on the Child Sexual Behavior Inventory (CSBI) — 28.8; 18.1 Scores on a scale
Phase 2 N=10 Memantine Treatment of Compulsive Buying
Compulsive Buying
Primary: Yale Brown Obsessive Compulsive Scale Modified for CB (CB-YBOCS) — 22 units on a scale
N/A N=61 A Mindfulness-based Intervention for Older Women With Low Sexual Desire
Hypoactive Sexual Desire Disorder · Sexual Dysfunction · Female Sexual Dysfunction
Primary: Feasibility - Number of Enrolled Women Participating in All Sessions — 15; 22 Participants — p=0.027
Phase 4 N=40 Role of the Melanocortin-4 Receptor in Hypoactive Sexual Desire Disorder
Hypoactive Sexual Desire Disorder
Primary: Changes in Blood Oxygen Level Dependent (BOLD) Signal Change on Functional MRI — 9.98; 7.67 BOLD signal change
N/A N=148 Randomized Comparison of Mindfulness Versus Group Support for Treatment of Low Sexual Desire in Women
Low Female Sexual Desire
Primary: Female Sexual Distress Scale-Revised (FSDS-R) — 22.88; 25.68; 23.02; 23.87 units on a scale
N/A N=31 tDCS for Impulsivity and Compulsivity in Obesity
Impulsivity · Compulsive Overeating · Obesity
Primary: Change in NIH Examiner Flanker Task Reaction Time — -0.03; -0.12 seconds
N/A N=36 Reducing Internet Gaming
Internet Gaming Disorder
Primary: Percentage of Participants Who Complete All 6 Sessions — 78.9 percentage of participants
N/A N=293 Men's Sexual Risk Behaviors: Alcohol, Sexual Aggression, and Emotional Factors
Sexual Behavior · Alcohol Drinking · Sexual Aggression
Primary: Mean Score of Sexual Risk Intentions — 2.35; 1.67; 2.15; 1.37 score on a scale — p=<.01
N/A N=1,647 Study of Long-term Efficacy and Mechanisms Underlying the Impact of a Web-based Sexual and Relationship Health Promotion Program With Young Adult Community College Students
Sexual Behavior · Sexual Assault · Violence, Domestic
Primary: Relationship Satisfaction — 4.22; 4.21; 4.29 score on a scale — p=0.983
N/A N=935 The SOLVE-IT National Randomized Trial
HIV Infections
Primary: Residualized Change in Counts of Unprotected Anal Intercourse at 3 Months — .10; -.09 Res. Change in Counts of UAI at 3 months
N/A N=26 The Effect of Self Stigma Tailored Cognitive Behavioral Therapy on Gambling Disorder
Gambling Addiction · Gambling Disorder · Gambling Disorder Treatment
Primary: Change in Self-Stigmatization Score as Measured by the Self-Stigma Scale (SSS). Baseline (Week 0) to Post-treatment (Week 4) and Follow-up (Week 8) — 82.77; 110.3…
Phase 2 N=28 N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers
Gambling · Tobacco Use Disorder
Primary: Yale-Brown Obsessive Compulsive Scale Modified for Pathological Gambling Total Score — 23.5; 20.4 units on a scale
N/A N=60 A Psychotherapy Development Study for Internet Gaming
Internet Gaming Disorder
Primary: Percentage of Participants Who Completed All 6 Sessions — 40.6 percentage of participants
Phase 3 N=31 Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment
Binge-Eating Disorder · Obesity
Primary: Binge Eating Frequency (Continuous) — 0.8; 12.1 Eating events/28 days — p=.0002
Phase 2 N=80 Bupropion in Sexual Dysfunction Among Methadone Maintenance Treatment Men
Sexual Dysfunctions, Psychological · Hypoactive Sexual Desire Disorder · Erectile Dysfunctions
Primary: Number of Participants With a Score of ≤2 (Much/Very Much Improved) on the Clinical Global Impression Scale Adapted for Sexual Function (CGI-SF) at Week 6 Between…
Phase 1 N=41 Bupropion For Reducing High-Risk Behaviors in Depressed Men Who Have Sex With Men (MSM)
HIV Infections · Depression
Primary: The Number of Sexual Partners in Unprotected Anal Intercourse Reported at 6 Months Minus the Number Reported at Enrollment. — -2.5; -4 Sexual partners — p=0.9
N/A N=50 Cognitive Behavioral Therapy for Adolescent Binge Eating and Loss of Control Eating
Binge Eating · Eating Disorders in Adolescence · Overweight and Obesity
Primary: Binge (Loss-of-control) Eating Episode Frequency — 1.52; 6.05 episodes of behavior — p=.01
Phase 2 N=59 Reducing HIV Risk Among Episodic Substance Using Men Who Have Sex With Men (SUMSM)
HIV Infections · Episodic Substance Use
Primary: Total Unprotected Anal Intercourse Events (Exclusive of Those Events With a Primary HIV-negative Partner) — 4.23; 3.91; 3.41; 2.05 Self reported events in past 3 months
N/A N=66 Arbitration Between Habitual and Goal-directed Behavior in Obsessive-compulsive Disorder: Circuit Dynamics and Effects of Noninvasive Neurostimulation
OCD · Decision-Making · tDCS
Primary: Strength of Behaving Model-based (Goal-directed) — 0.09; 0.07; -0.08; 0.06 units on a scale
N/A N=403 Restore: Improving Sexual Outcomes of Gay and Bisexual Prostate Cancer Survivors
Prostatic Neoplasm
Primary: Urinary Function Scores — 80.1; 81.4 Scores on a scale (0-100)
N/A N=16 Surface Stimulation for Female Sexual Dysfunction
Female Sexual Dysfunction
Primary: 6 Weeks - Total FSFI Score — 26.0; 17.4 score on a scale — p=0.109
Phase 3 N=77 Drug Treatment for Pathologic Gambling Disorder
Gambling
Primary: Yale-Brown Obsessive Compulsive Scale for Pathological Gambling (PG-YBOCS) — 16.9; 18.6; 9.7; 12.9 units on a scale
Phase 4 N=28 Acamprosate in the Treatment of Pathological Gambling
Pathological Gambling
Primary: The Primary Efficacy Measure Was the Yale-Brown Obsessive Compulsive Scale Modified for PG (YBOCS-PG). — -.985 units on a scale — p=0.05
Phase 2 N=170 Biobehavioral Interventions for HIV-negative, Stimulant Using Men Who Have Sex With Men
HIV Seroconversion · Stimulant Abuse
Primary: Time From Exposure to Truvada Initiation — 32.8; 33.0 hours
Phase 3 N=20 Tolcapone in Obsessive Compulsive Disorder
Obsessive-Compulsive Disorder
Primary: Yale Brown Obsessive Compulsive Scale (Y-BOCS) — -4.24; -1.10 mean change in YBOCS score
Phase 2 N=34 Clinical Study to Determine if Ecopipam Can Reduce Urges to Gamble
Pathological Gambling
Primary: Statistically Significant (p<0.05) Decrease From Baseline in Yale Brown Obsessive Compulsive Scale Modified for Pathological Gambling — 13.9 YBOCS score
N/A N=25 Harm Reduction Strategies for Gay, Bisexual and Other Men Who Have Sex With Men Engaging in Chemsex
Harm Reduction
Primary: Usability of the App — 2.14 Scores on the MAUQ
N/A N=91 Applying Novel Technologies and Methods to Self-Regulation: Behavior Change Tools for Smoking and Binge Eating
Smoking · Binge Eating · Behavior
Primary: Binge Eating Episodes - Loss of Control — 0.212 episodes — p=0.066
Phase 3 N=23 Clinical Neurobiology of Serotonin and Addiction
Cocaine Dependence
Primary: Immediate Memory Task