Clinical Trial Search

Primary: Change From Baseline in Colonic Transit Time (CTT) — -727; -15; 366 minutes

Primary: Whole Gut Transit Time

Primary: Severity of Constipation Symptoms — 0.96; 0.97; 0.63; 0.67 score on a scale

Primary: Relaxation Time in Ascending Colon — 312; 256 seconds*minutes

Primary: Treatment Recovery — 33; 19 participants — p=0.024

Primary: Adverse Events — 0 Participants

Primary: Complete Spontaneous Bowel Movement (CSBM) Overall Responder — 46; 42; 7 participants — p=<0.0001

Primary: Bowel Movement (BM) Within 3 Days of Surgery — 29; 32 Participants — p=0.41

Primary: Responder for Complete Spontaneous Bowel Movement (CSBM) — 10; 14; 17; 22 participants — p=<0.05

Primary: Change of Mucus and Mucin Secretion in Patients With Chronic Constipation and in Controls. — 260; 133; 229; 161 mg/hour

Primary: Number of Patients With Adverse Events (AEs) and Serious Adverse Events (SAEs) — 241; 14 Patients

Primary: Time to First Bowel Movement After Surgery — 66.5; 68.3 hours

Primary: Responder of Complete Spontaneous Bowel Movement (CSBM) — 26; 5; 34; 55 participants — p=<0.05

Primary: Change of Clostridium Butyricum Miyairi Expression After Probiotics Supplementation in Constipated Children. — 0.00486; 0.0000148; 0.00000189 number of bacteria per mg…

Primary: Change in Colonic Transit Time From Baseline to Day 15 — -1.7; 4.0; 2.5; 2.6 Hours

Primary: Frequency of Defecation. — 3.9; 5.1 days/week — p=<0.05

Primary: Median Number of Observed Weekly Spontaneous Bowel Movements (SBM) Per Month — 2.66; 2.75; 2.70; 2.75 Weekly SBMs

Primary: Colonic Transit at 24 Hours — 2.68; 3.12; 1.93 units on a scale — p=0.059

Primary: The Percentage of Subjects With an Average of ≥3 Spontaneous Complete Bowel Movements (SCBM) Per Week Over the 24 Week Treatment Period — 20.7; 25.1 percentage of…

Primary: Percent of Responders in the Last Four Weeks of the Double-Blind Treatment Period — 17.0; 17.8 percentage of subjects — p=0.9002

Primary: Presence of Small Intestinal Bacterial Overgrowth — 8; 9 Participants — p=0.75

Primary: Change From Pretreatment in Weekly Normalized Spontaneous Bowel Movement (SBM) Frequency — 2.59; 3.25; 3.57; 4.29 SBMs per week — p=0.0337

Primary: % of Subjects With Treatment Emergent Adverse Events — 108 Participants

Primary: Change in Methane Production — 10645; 14635 parts per million*minutes

Primary: Colonic Geometric Center at 24 Hours (GC24) Measured by Scintigraphy — 1.96; 1.98; 2.45; 1.84 units on a scale — p=<0.01

Primary: Complete Spontaneous Bowel Movement (CSBM) Overall Responder — 13; 34; 43; 202 participants — p=0.0012

Primary: 9/12 Week Complete Spontaneous Bowel Movement (CSBM) 3+1 Responder — 13; 24; 158; 129 participants — p=0.0264

Primary: Overall Responder 9/12 Weeks — 18.6; 16.8; 19.0; 10.7 % of Overall Responder 9/12 weeks

Primary: % of Subjects With Treatment Response — 42; 34; 30; 20 Participants — p=0.034

Primary: Patient Assessment of Constipation Symptoms Questionnaire (PAC-SYM) Score — 1.1; 0.6 score