N/A N=21 Delayed Cord Clamping for Congenital Diaphragmatic Hernia
Congenital Diaphragmatic Hernia
Primary: Proportion of Infants Who Are Intubated Prior to Umbilical Cord Clamping — 17 Participants
Clinical Trial Search
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N/A N=142 Umbilical Cord Clamping: What Are the Benefits
Delayed Cord Clamping
Primary: Change of Heart Rate After Delayed Umbilical Clamping — 164; 157; 163; 155 bpm
N/A N=300 Milking Versus Delayed Cord Clamping in Full Term Neonates
Neonatal Anemia
Primary: Neonatal Hemoglobin Level — 11.86; 11.95 gram%
N/A N=74 Cord Clamping Level Above or Below Mother's Perineum
Pre-term Birth · Delayed Cord Clamping
Primary: Hematocrit Level — 51.5; 52.6 % of blood composed of red blood cells — p=0.572
N/A N=860 Umbilical Cord Milking in Non-Vigorous Infants
Birth Asphyxia
Primary: Number of Neonatal Participants Admitted to the NICU for Predefined Criteria — 199; 239; 53; 52 Participants — p=.87
Phase 2 N=256 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury
Intraventricular Hemorrhage · Periventricular Leukomalacia · Brain Injury
Primary: Percent of Survivors With no Severe IVH (Grades 3 or 4) or PVL — 22.2; 14.9; 17.1; 10.9 percent of participants
N/A N=605 Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU)
Neurodevelopmental Abnormality
Primary: Total and Domain Scores on the Ages and Stages Questionnaire, Third Edition. — 55; 55; 60; 60 score on a scale — p=0.87
N/A N=52 Neonatal Warming to Prevent Hypothermia
Hypothermia
Primary: Temperature at Arrival to Warmer — 36.9; 37.0 degrees Celsius
N/A N=34 Cardiac and Cerebral Hemodynamics With Umbilical Cord Milking Compared With Early Cord Clamping
Birth Asphyxia With Neurologic Involvement
Primary: StO2 in the First 10 Minutes of Life — 70; 74.5 percent
N/A N=60 Severing Nuchal Cord at the Time of Delivery.
Perinatal Outcome
Primary: Umbilical Cord pH — 7.29; 7.32 pH — p=0.1
N/A N=1,923 Impact of Chlorhexidine Cleansing on Bacteria Colonizing the Umbilical Cord of Infants in Bangladesh
Infection
Primary: Colonization at Day 1 Swab — 466; 396; 605; 239 Participants
N/A N=27 SI + CC Versus 3:1 C:V Ratio During Neonatal CPR
Heart Arrest · Birth Asphyxia · Bradycardia
Primary: Return of Spontaneous Circulation — 90; 615 seconds
N/A N=65 Utility of Placental/Umbilical Cord Blood in Early Onset Neonatal Sepsis in Very Low Birth Weight Infants
Preterm Infant · Early-Onset Neonatal Sepsis · Umbilical Cord
Primary: White Blood Cell Count (WBC) (1) — 8257 ratio of cells/mm3
N/A N=400 Timing of Antibiotic Prophylaxis for Cesarean Deliveries
Infection
Primary: Endometritis and Wound Infection — 6; 4 patients infected
N/A N=112 Immediate Postplacental Insertion of IUDs at Time of Cesarean Delivery: A Randomized Clinical Trial
Intrauterine Devices · Cesarean Section
Primary: IUD Use — 32; 40 participants
N/A N=9 Chest Compression and Sustained Inflation
Newborn Infants Having Asystole or Bradycardia at Birth
Primary: Time Needed to Achieve Return of Spontaneous Circulation — 31; 138 seconds — p=0.05
N/A N=63 Neonatal Resuscitation - Sustained Inflations
Premature Birth
Primary: Expiratory Tidal Volume — 153; 194 ml/kg/min
N/A N=25 Cord Blood Transfusion In Preterm Neonates (CB-TrIP)
Premature Infant Disease · Transfusion Related Complication · Fetal Hemoglobin
Primary: Median Percentage of HbF at 32 Weeks of Post Menstrual Age — 93.2; 90.8; 58.0; 69.0 percentage of total Hb — p=<0.0001
Phase 3 N=39,679 Zambia Chlorhexidine Application Trial
Sepsis
Primary: All-cause Neonatal Mortality — 282; 263; 18168; 19045 participants
N/A N=25 Delayed Rewarming for Neuroprotection in Infants Following Cardiopulmonary Bypass Surgery
Post-Op Complication
Primary: Infants With Elevated s100b and NSE — 11; 9 Participants
N/A N=78 Randomized Control Trial of Second Stage of Labor
Labor Complications
Primary: Number of Patients Delivered by Cesarean — 16; 8 Participants
N/A N=70 Impact of Skin to Skin Contact on Maternal Satisfaction, Pain Scores, and Narcotic Usage After Cesarean Delivery
Skin to Skin Contact in Cesarean Deliveries
Primary: Maternal Evoked Pain Scores — 43.55 units on a scale
N/A N=84 Cord Blood 25(oh)-Vitamin D Level in Preterm Infants and Associated Morbidities
Respiratory Distress Syndrome
Primary: Respiratory Distress Syndrome — 52; 3 participants
Phase 4 N=46 Platelet Transfusion During Neonatal Open Heart Surgery
Cardiac Disease · Cardiac Surgery · Cardiopulmonary Bypass
Primary: Amount of Blood Products Transfused — 58; 103 milliliter per kilogram (mL/kg)
Phase 3 N=1,032 Newborn Ventilation in the Delivery Room: Could it be Improved With a T-piece Resuscitator?
Resuscitation
Primary: Proportion of Infants With a HR ≥ 100 Bpm at 2 Minutes of Life. — 93.7; 88; 93 percentage of participants
Phase 3 N=648 Delivery Room Management Trial of Premature Infants at High Risk of Respiratory Distress Syndrome
Respiratory Distress Syndrome, Newborn
Primary: Death or Chronic Lung Disease — 76; 68; 62 participants
Phase 3 N=120 Calcium Chloride for Prevention of Blood Loss During Intrapartum Cesarean Delivery
Uterine Atony · Uterine Atony With Hemorrhage · Postpartum Hemorrhage
Primary: Quantitative Blood Loss — 840; 1051 milliliters — p=<0.05
N/A N=50 Effect of Birth on Immunological Parameters in Cord Blood
Immunologic Activity Alteration
Primary: Cytokines Profile in Cord Blood Plasma — 1.6; 21.81; 165; 14 pg/ml
N/A N=77 Preoperative Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Congenital Heart Disease · Disorder of Fetus or Newborn
Primary: Primary Endpoint: Number of Participants With Low Cardiac Output Syndrome (LCOS) or Death at 36 Hours From Admission to the Intensive Care Unit (ICU) After Surgery…
N/A N=150 Trial Comparing Iron Supplementation Versus Routine Iron Intake in Very Low Birth Weight Infants
Iron Deficiency Anemia
Primary: Hematocrit (Hct) at 36 Wks Post Menstrual Age (PMA) — 29.2; 28.2 % Hematocrit — p=0.59