Phase 1 N=48 The Effect of Palatal Brushing on Denture Stomatitis
Denture Stomatitis
Primary: Palatal Inflammation — 3; 3; 2.5; 2 units on a scale — p=<0.0001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=53 Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Edentulous Jaw · Edentulous Mouth
Primary: Change From Baseline in Patient Comfort for as Assessed by Numerical Scale. — 0.99; 1.16 units on a scale
N/A N=38 Assessing Effects of a Denture Gel on Gum Abrasions
Gum Injury
Primary: Abrasion Assessment (Number) — 3.65; 4.11 number of abrasions
Phase 3 N=119 To Evaluate Oral Health and Quality of Life Associated With Use of a Denture Adhesive
Denture Retention
Primary: Gum Health Analysis by Change From Baseline in Overall Mean Scores of Participant Responses to the Gum Comfort Questionnaire After 12 Weeks — 4.1; 4.5; -0.6; -0.4 Score…
N/A N=19 Frequency of Denture Cleanser Use and Denture Cleanliness
Denture Cleansers
Primary: Change From Baseline in Aerobic Bacteria Microbial Count on Day 7 — -1.78; -1.20 log10(CFU[colony forming unit]/disc+1) — p=0.0144
N/A N=31 Oral and Dermal Tolerability Clinical Study of an Experimental Denture Wipe
Denture Cleansers
Primary: Proportion of Participants Experiencing or Reporting Treatment Emergent (TE) Oral Adverse Events (AEs) on or Before 14 Days of Use — 0.039; 0.013 Proportion of…
Phase 4 N=49 A Clinical Study to Evaluate the Efficacy of a Range of Dental/Denture Products for Improved Oral Health in Partial Denture Wearers
Gingivitis
Primary: Mean Bleeding Index (BI) at Week 12 — 0.45; 0.76 Score on a scale — p=<0.0001
Phase 4 N=57 The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Per-implant Mucositis
Peri-implant Mucositis
Primary: Global Probing Depth — 2.37; 2.64 mm — p=0.28
Phase 3 N=60 To Access the Effects of Mucositis in Adults With Dental Implants
Mucositis
Primary: Bleeding on Probing — 53.8; 52.3 Percentage of bleeding sites — p=0.05
Phase 2 N=86 Open-label, Phase II Study of Stomatitis Prevention With a Steroid-based Mouthwash in Post-menopausal Women With Estrogen-receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)- Metastatic or Locally Advanced Breast Cancer
Advanced Breast Cancer
Primary: Number of Participants With Stomatitis Grade ≥ 2 — 2; 83; 1 Participants — p=<0.001
N/A N=96 Oral Tissue Tolerance of a Mouthrinse
Dental Health
Primary: Change in Tooth Color as Represented by ΔE at 8 Weeks Post Baseline From the CIElab Assessment — 0.909; 1.035 units on a scale — p=0.168
N/A N=83 Evaluation of a Experimental Denture Adhesive to Prevent Food Ingress
Denture Retention
Primary: Combined Mass of Peanuts (Gram) (From Upper and Lower Dentures) for Reference Denture Adhesive and on no Adhesive Use — 0.06; 0.08 gram (g) — p=0.0987
Phase 4 N=48 A Study to Investigate Food Occlusion Efficacy of a Denture Adhesive in Denture Wearers
Denture Retention
Primary: Food Occlusion Analysis of Combined Mass of Peanuts Under Combined Maxillary (Upper) and Mandibular (Lower) Dentures — 5.56; 29.13 Milligrams (mg) — p=<0.0001
Phase 2 N=9 Treatment of Oral Premalignant Lesions With 5-ALA PDT
Leukoplakia · Erythroplakia
Primary: Maximum Tolerated Dose — 8 J/cm2
N/A N=48 A Study to Investigate a Method to Measure Food Occlusion by Denture Adhesives in Denture Wearers
Denture Retention
Primary: Mass of Peanuts Under Combined Maxillary and Mandibular Dentures (Denture Adhesive Applied Per Conventional Pattern) — 0.01184; 0.00944; 0.07853 Grams
Phase 2 N=37 Therapeutic Effects of "Ibuprofen, Diphenhydramine and Aluminium MgS" on Recurrent Aphthous Stomatitis
Aphthous Stomatitis
Primary: Effect of Ibuprofen, Diphenhydramine and Aluminium MgS Measured on Decrease in Pain Level and Burning Sensation — 3.176; 3.821 scores in Visual Analogue Scale
N/A N=253 Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
Gingivitis
Primary: Number of Bleeding Sites at Week 12 — 42.02; 67.36 number of bleeding sites — p=<0.0001
Phase 3 N=105 Clinical Study to Examine Brushing on Dental Implants
Gingival Diseases
Primary: Mombelli Plaque Index (mPI) for Natural Teeth — 1.96; 1.82 units on a scale — p=0.05
N/A N=23 A Bite Force Study Comparing Two New Test Adhesives With Currently Marketed Denture Adhesive
Denture Retention
Primary: Area Over Baseline Over 12 Hours (AOB0-12) for Test Adhesive 1 Versus (vs.) No Adhesive — 2.09; 1.43 lbs — p=0.1770
N/A N=80 Oral Irritation Study of Two Experimental Mouthrinses
Oral Manifestations
Primary: Percentage of Participants With an Abnormal Condition by Anatomical Site at Screening — 0; 0; 0; 0 Percentage of Participants
Phase 4 N=69 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis
Gingivitis · Plaque, Dental · Periodontal Diseases
Primary: Degree of Plaque as Assessed by the Turesky Modification of the Quigley-Hein Plaque Index — 0.41; 0.43 score on a scale
Phase 2 N=38 Short-term Effect of 2% Atorvastatin Dentifrice in Periodontal Status.
Chronic Periodontitis
Primary: Change in Periodontal Inflammation Surface Area (PISA) — 638.16; 288.72 square millimeters
N/A N=150 Caries Prevention Effect of S-PRG Filler Incorporated in Denture Base Resins on Edentulous Elderly People
Dental Caries
Primary: Saliva Fluoride Concentration (Part Per Million,Ppm) — 0.05; 0.05; 0.09; 0.22 part per million,ppm — p=<0.05
Phase 2 N=50 Herbal Mouthrinse for Oral Mucositis Study
Oral Mucositis
Primary: Maximum Change in Mean Mouth and Throat Soreness (MTS) Score From Baseline Through Weeks of Radiation Therapy Using the MTS Question of the Modified Oral Mucositis Daily…
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005
Phase 3 N=98 A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
Gingivitis
Primary: Evaluation and Comparison of Gingival Health Measured by Bleeding Index (BI) at 24 Weeks — 0.11; 0.19 Score on scale — p=<0.0001
Phase 3 N=221 Gentian Violet Vs. Nystatin Oral Suspension for Treatment of Oropharyngeal Candidiasis
HIV-1 Infection
Primary: Number of Participants With Clinical Efficacy — 76; 73 participants
N/A N=32 Induced Gingivitis & Intra-oral Imaging
Plaque Induced Gingivitis
Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale
N/A N=27 Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Oral Leukoplakia · Oral Lichen Planus · Premalignant Lesion
Primary: Number and Percentage of Lesions That Were Stained Positive — 29; 28 lesions — p=0.005