Phase 4 N=798 Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Heart Disease
Primary: Number of Patients With Atrial Arrhythmia — 121; 134 Participants — p=0.34
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=50 Alternative Sedation During Bronchoscopy
Sedation
Primary: Decreased Minute Ventilation — 0.736; 0.764 percentage of baseline — p=<0.0001
Phase 3 N=50 Sedation Using Intranasal Dexmedetomidine in Upper Gastrointestinal Endoscopy
Gastrointestinal Disease
Primary: Consumption of Rescue Patient Controlled Propofol — 42.4; 28.6 mg
Phase 2 N=15 Repurposing Dexmedetomidine as an Orally Administered Sleep Therapeutic
Sleep · Insomnia
Primary: Hemodynamic Stability (Phase I) — 0; 0; 0; 0 Participants
Phase 4 N=50 Dexmedetomidine for Sedation of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Bronchoscopy
Primary: Hypoxemia During Maintenance — 8; 14 Participants
N/A N=23 Dexmedetomidine Versus Midazolam for Facilitating Extubation
Critical Illness
Primary: Time From Study Drug Initiation to Tracheal Extubation — 2.9; 3.4 days — p=0.8
Phase 3 N=469 Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep
Postoperative Delirium · Sleep · Anesthesia
Primary: Incidence of Delirium — 5; 16 Participants — p=0.029
N/A N=10 Polysomnographic Study Comparing the Use of Dexmedetomidine and Zolpidem to Induce Natural Sleep
Insomnia
Primary: Change in Sleep Quality — 33.2; 0; -35; 0 minutes
Phase 2 N=19 The Use of Dexmedetomidine for EEG Sedation in Children With Behavioural Disorders
Procedural Sedation · Behavior Disorders
Primary: Number of Patients That Reach a Score Equal or Lower Than 2 Ten Minutes After the Infusion of Dexmedetomidine (Assessed With the PSSS Pediatric Sedation State Scale)…
Phase 4 N=60 Dexmedetomidine Versus Morphine and Midazolam in Prevention and Treatment of Delirium After Adult Cardiac Surgery
Delirium
Primary: The Incidence of Delirium (Number of Patients (in Digits)) — 1; 2 participants
Phase 4 N=50 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
Shoulder Pain
Primary: Number of Participants That Need an Airway Intervention. — 0; 5 participants
Phase 4 N=77 Dexmedetomidine Versus Propofol in Vitreoretinal Surgery
Retinal Detachment
Primary: Adequate Sedation Via Bispectral Index Score (BIS)and University of Michigan Sedation Scale (UMSS) — 84.8; 88; .90; .94 units on a scale — p=0.04
Phase 4 N=109 Dexmedetomidine in Pediatric Tonsillectomy
Pediatric Adenotonsillectomy · Post Operative Analgesia
Primary: Amount of Post-Operative Rescue Morphine Required for Analgesia — 45.2; 37.0; 43.3; 36.5 ug/kg
Phase 4 N=90 Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation
Ultrasound · CT Scans · MRIs
Primary: Number of Subjects Who Had Success in Sedation — 0; 2; 0; 0 participants
N/A N=81 Intranasal Dexmedetomidine Premedication
Benign Neoplasm of Vocal Fold - Glottis
Primary: Extubation Time After Intranasal Dexmedetomidine Premedication — 18.58; 17.16; 16.21; 14.74 min
Phase 4 N=144 A Comparison of Dexmedetomidine Versus Propofol for Use in Intravenous Sedation
Anesthesia
Primary: Respiratory Events Requiring Intervention — 17; 2 Participants
N/A N=16 Closed Loop Acoustic Stimulation During Sedation With Dexmedetomidine
Sleep · Sedation Complication
Primary: Difference in EEG Slow Wave Activity From Sham to In-phase Stimulation — 1.592; 1.694 Log(μV squared)
N/A N=121 Emergence Agitation Between Dexmedetomidine and Sevoflurane Anesthesia
Emergence Delirium
Primary: Emergence Agitation — 3.9; 2.5 Score on a scale — p=0.001
Phase 4 N=128 Safety and Efficacy of Dexmedetomidine (DEX) for Sedation of Subjects ≥1 Month to <17 Years Undergoing MRI Scans
MRI Sedation
Primary: Percentage of Participants at the DEX High Dose Versus Low Dose in the Combined Age Cohorts Who Did Not Require Concomitant PRO to Complete MRI — 63.2; 14.3 Percentage…
Phase 4 N=40 Sedation Effect of Dexmedetomidine Versus Remifentanil to Fibreoptic Intubation
Intubation; Difficult
Primary: Endoscopy Scores — 3; 2 units on a scale
Phase 3 N=84 Cerebral Perfusion Pressure Using Precedex and Other Sedatives
Endotracheal Intubation · Continuous IV Sedation · ICP Monitoring
Primary: Variability of Intracranial Pressure (ICP) — 5.66; 5.61 mmHg
Phase 4 N=114 Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
Colonoscopy
Primary: Percentage of Subjects Ready for Discharge in Each Group at 30 Minutes Post Procedure — 26; 44 Participants
N/A N=60 Conscious Sedation for Epilepsy Surgery
Epilepsy
Primary: Patients Satisfaction — 6.33; 6.45 score on a scale
Phase 4 N=39 The Synergistic Effect of Dexmedetomidine on Propofol for Sedation for Pediatric Endoscopy
Anesthesia
Primary: Propofol Requirements With Pre-treatment of Dexmedetomidine With Children Who do Not Receive Dexmedetomidine. — 0.4; 0.23 mg/kg/min
Phase 4 N=285 Dexmedetomidine and Delirium in Patients After Cardiac Surgery
Delirium · C.Surgical Procedure; Cardiac · Postoperative Complications
Primary: Incidence of Postoperative Delirium — 7; 11 Participants — p=0.341
Phase 3 N=75 Intranasal Dexmedetomidine Premedication in Children
Preoperative Sedation
Primary: University of Michigan Sedation Scale — 15; 25; 22; 11 Participants — p=0.025
Phase 1 N=56 Understanding Dexmedetomidine In Infants Post-Operative From Cardiac Surgery
Hypoplastic Left Heart · Tetralogy of Fallot · Tricuspid Atresia
Primary: PK Profile of Dexmedetomidine — 28 mL/min/(kg^0.75)
N/A N=24 Dexmedetomidine as Adjunctive Therapy for Alcohol Withdrawal
Acute Alcohol Withdrawal
Primary: Cumulative Lorazepam Dose Over the First Seven Days of Alcohol Withdrawal — 180.5; 112.5; 109.1 mg — p=0.64
Phase 3 N=168 Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial)
Delirium · Agitation
Primary: Duration of Agitation (in Hours), Defined by a RASS ≥ +1 — 1; 2 hours
Phase 3 N=28 Use of Dexmedetomidine to Reduce Emergence Delirium Incident in Children
Agitation · Anesthesia · Pediatrics
Primary: Number of Participants With Emergence Delirium — 1; 7; 13; 7 participants