N/A N=287 Dual Diagnosis Self-Help Referral
Dual Diagnosis
Primary: Psychiatric Functioning at 6 Months — .333; .387 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=406 Dual Diagnosis Inpatients: Telephone Monitoring RCT to Improve Outcomes
Diagnosis, Dual (Psychiatry)
Primary: Readiness to Attend Substance Use Disorder Continuing Care — 1.8; 2.2 units on a scale — p=<.05
N/A N=5,325 Digital Detection of Dementia (D Cubed) Studies: D2
Alzheimer Disease and Related Dementias (ADRD)
Primary: 12-Month Cumulative Incidence of ADRD Diagnoses — 213; 134; 355 Number of new ADRD cases — p=0.006
N/A N=102 A Brief Community Linkage Intervention for Dually Diagnosed Individuals
Schizophrenia · Psychotic Disorders · Substance-Related Disorders
Primary: Treatment Engagement — 4.2; 1.4; 7.2; 1.5 number of treatment sessions attended — p=<0.001
Phase 3 N=31 Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder
Bipolar Disorder
Primary: Time to Treatment for Emerging Symptoms of a Mood Relapse — 17.8; 15.9 weeks
Phase 4 N=49 Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems
PTSD · Alcohol Use Disorder
Primary: Percent Heavy Drinking Days — 55.5; 65.1 percentage of days
Phase 4 N=245 Does Dual Therapy Hasten Antidepressant Response?
Major Depressive Disorder
Primary: Time to Remission, Defined by the Week of Onset of Persistent Hamilton Rating Scale for Depression (HAM-D 17) <= 7, With no Subsequent HAM-D 17 > 7 — 8; 9; 10 weeks…
Phase 4 N=96 Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders
Alcohol Use Disorder · Bipolar Disorder · Schizoaffective Disorder Bipolar Type
Primary: Baseline-to-Exit Change in Drinks Per Drinking Day (TLFB) — -1.98; -2.82; -1.22 Standard Drinks per Drinking Day
Phase 4 N=75 Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder
Borderline Personality Disorder
Primary: Suicide Attempts — 2; 1; 4; 1 suicide attempt
N/A N=60 A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence
Amphetamine Abuse · Amphetamine Dependence · Bipolar Disorder
Primary: Depression Symptoms — 26.2; 33.1 scores on a scale — p=0.05
N/A N=8 Clinical Interviews With Detainees With Early Psychosis
First-Episode Psychosis
Primary: Number of Referrals to Correctional Health Services (CHS) — 8 Participants
N/A N=50 Dual-Tracer Theranostic PET
Neuroendocrine Tumors · Prostate Cancer
Primary: Completion of Two PET/CT Scans Per Patient as Dictated by Assigned Arm — 30; 30; 40 PET/CT scans
Phase 3 N=54 Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
Bipolar Disorder
Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score — -9.64; -5.32 units on a scale
Phase 2 N=17 Dichotic Listening as a Predictor of Medication Response in Depression
Major Depression · Dysthymia · Depressive Disorder Not Otherwise Specified
Primary: Hamilton Depression Scale (HAM-D) — 10; 9 score on a scale
N/A N=81 Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
Posttraumatic Stress Disorders · Combat Disorders · Alcohol Dependence
Primary: Change in Post-traumatic Stress Disorder Symptomatology — -51.2; -35.9; -22.3; -10.9 score on a scale
Phase 4 N=130 Citicoline for Bipolar 1 Disorder and Cocaine Dependence
Bipolar Disorder · Cocaine Dependence
Primary: Percentage of Participants With Presence of a Cocaine-Positive Urine Screen — 59.0; 49.2 percentage of participants
Phase 4 N=60 Does The Addition Of Divalproex Sodium ER To An Atypical Antipsychotic Drug (APD) Improve Cognition And Psychopathology In Outpatients With Schizophrenia (SCH) Or Schizoaffective Disorder (SAD)?
Schizophrenia · Schizoaffective Disorder
Primary: Change in Cognition and Psychopathology Disorders as Measured on the MATRICS Consensus Cognitive Battery (MCCB) — 14.1; 14.3 units on a scale
N/A N=100 Pathway to Detection & Differentiation of Delirium & Dementia in the Emergency Department
Cognitive Impairment · Emergency Care · Dementia
Primary: Percentage of Patients With Confirmed Delirium or Dementia — 30.8 percentage of participants
N/A N=292 Early Detection and Intervention for the Prevention of Psychosis
Schizophrenia · Bipolar Disorder · Depression
Primary: Psychotic Symptoms — 9.2; 6.7 units on a scale — p=.0034
N/A N=205 Depression Attention for Women Now (The DAWN Study)
Depressive Disorder
Primary: Depression Treatment Outcome — 0.96; 1.33 units on a scale
Phase 4 N=17 Dichotic Listening as a Predictor of Medication Response in Depression
Major Depressive Disorder · Dysthymia
Primary: Hamilton Depression Scale (HAM-D) — 11.2; 9.7; 11.3 units on a scale
N/A N=183 Integrated vs Sequential Treatment for PTSD and Addiction
PTSD · Substance Addiction
Primary: PTSD Symptoms — 55.5; 54.1 units on a scale
Phase 4 N=20 Treatment of Nicotine Dependence and Acute Depression
Major Depressive Disorder · Nicotine Dependence
Primary: Hamilton Depression Scale Score — -.5322 percentage of change in depression — p=<.001
Phase 2 N=119 Integrated Alcohol Disorder and PTSD Treatment
PTSD · Alcoholism
Primary: Clinician Administered PTSD Scale (CAPS) — 43.2; 42.1; 25.8; 32.9 score on a scale — p=.002
Phase 2 N=26 Valproate Efficacy in Cocaine-Bipolar Comorbidity
Bipolar Disorder · Cocaine Dependence
Primary: Change From Baseline in Percentage of Cocaine-abstinent Days — 16.4; 14.5 percentage of days cocaine abstinent
N/A N=60 Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Bipolar Disorder · Alcohol Drinking · Alcohol Use Disorder
Primary: Level of Intoxication (Subjective Response) on Each Condition Day After Drinking Relative to How They Felt When Arriving to the Lab on That Respective Day )Prior to…
N/A N=294 INTEGRATE-D: A Pilot Test to Support Integration of Medical and Psychosocial Care for People With Type II Diabetes
Type II Diabetes · Primary Health Care · Behavioral Health
Primary: Acceptability of Intervention — 0.60 units on a scale
Phase 3 N=150 TRIAD - Treatment of Insomnia and Depression
Sleep Initiation and Maintenance Disorders · Depression
Primary: Percent of Participants With Depression Remission — 36.0; 43.8 percentage of participants in arm
N/A N=32 Improving Identification of Mental Health/Substance Use Disorders in HIV Primary Care: Pilot Clinical Response
HIV Infections
Primary: Mental Health or Substance Use Issue Raised in Visit — 32 Participants
Phase 4 N=41 Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder
Alcohol Dependence · Anxiety Disorder
Primary: Treatment Adherence — 15 Participants