Phase 4
Completed N=75
Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder
Source: ClinicalTrials.gov NCT00533117 ↗Enrolled (actual)
75
Serious AEs
4.0%
Results posted
Aug 2017
Primary outcomePrimary: Suicide Attempts — 2; 1; 4; 1 suicide attempt
◆ Published Evidence
Highly cited
437citations · ~73 / year
Psychological therapies for people with borderline personality disorder.
Summary
This study will determine whether dialectical behavior therapy and fluoxetine are more effective combined or alone in treating people with borderline personality disorder.
Linked Publications (2)
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Psychological therapies for people with borderline personality disorder.
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Psychosocial interventions for self-harm in adults.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Suicide Attempts |
2; 1; 4; 1 | — |
Eligibility Criteria
Inclusion Criteria
- Meets criteria for diagnosis of borderline personality disorder
- History of at least one suicide attempt or self-mutilation episode 12 months prior to study entry
- Experiences continued urges to self-mutilate or attempt suicide
- Stable living situation
- Use of effective birth control if sexually active
- Clinically stable enough to tolerate placebo condition
- Not participating in other forms of treatment during the study
Exclusion Criteria
- Any current organic mental syndromes, lifetime schizophrenic or bipolar disorders, psychotic disorders, or mental retardation
- Inability to complete psychiatric interview due to lack of cooperation or lack of comprehension
- Unable to tolerate fluoxetine or DBT
- Currently receiving treatment for an acute medical illness or other debilitating problem, including substance abuse or anorexia nervosa
- History of major depression lasting more than 3 months
- Current Hamilton depression score above 22 and not receiving treatment
- Pregnant or breastfeeding
Data sourced from ClinicalTrials.gov (NCT00533117) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.