Phase 3 N=179 Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)
Otomycosis
Primary: Percentage of Subjects With Therapeutic Cure — 14; 11; 53; 53 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=331 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients
Acute Otitis Media
Primary: Time to Cessation of Otorrhea — 6.83; 22; 4.94 days
N/A N=119 Ear Drops for Children With Otitis Media
Acute Otitis Media
Primary: Resolution of Otitis Media Symptoms — 14.2; 16.5; 7.5; 14.1 units on a scale — p=.002
Phase 3 N=385 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT)
Otitis Media With Effusion in Children · Otitis Media Recurrent
Primary: Percentage of Subjects With Sustained Clinical Cure at Day 8 — 76.2; 71.8; 56.8 percentage of participants
Phase 4 N=291 Acute Otitis Media (AOM) Therapy Trial in Young Children
Acute Otitis Media
Primary: The Time to Resolution of Symptoms, Defined as Acute Otitis Media-Severity of Symptoms (AOM-SOS) Score of 0 or 1, According to Treatment Assignment — 20; 9; 1; 2…
Phase 3 N=331 Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients
Acute Otitis Media
Primary: Time to Cessation of Otorrhea — 7.69; 22; 3.75 days
Phase 3 N=356 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2
Otitis Media With Effusion in Children · Otitis Media Recurrent
Primary: Percentage of Subjects With Sustained Clinical Cure at Day 8 — 77.1; 75.5; 65.3 percentage of participants
Phase 3 N=112 Phase III Efficacy and Safety Study of Miconazole Oil for Otomycosis
Otomycosis
Primary: Number of Participants With Clinical Cure — 19; 18 Participants
N/A N=101 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media
Chronic Otitis Media
Primary: Number of Participants With Otomicroscopic Signs of Otorrhea in Either Ear — 13; 27; 15; 23 participants
N/A N=239 Effect of Prevnar 13 on Ear Infections in Children
Otitis Media
Primary: Percentage of Middle Ear Fluid (MEF) Samples With Positive Results for Streptococcus Pneumoniae Serotypes 1, 3, 5, 6A, 7F, or 19A in Participants With Acute Otitis Media…
N/A N=210 Homeopathic Ear Drops for Otitis Media Study
Otitis Media
Primary: Severity of Symptoms of Otitis Media — 2.0; 2.0 units on a scale
Phase 3 N=266 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
Otitis Media With Effusion
Primary: Percentage of Participants Who Were Treatment Failures. — 21.3; 45.5 percentage of treatment failures
Phase 3 N=266 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
Otitis Media With Effusion
Primary: Percentage of Participants Who Were Treatment Failures — 24.6; 44.8 percentage of treatment failures
N/A N=56 Ear Acupuncture for Acute Sore Throat.
Acute Sore Throat
Primary: Reduction in Pain — 6.4; 6.2; 2.6; 6.0 score on a scale
Phase 1 N=24 Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in Adults With Acute Otitis Media
Acute Otitis Media
Primary: Number of Participants With Adverse Events — 2; 6 Participants
Phase 3 N=33 Open-Label Study of OTO-201 for Middle Ear Effusion Evaluating Trans-Tympanostomy Tube Administration
Bilateral Middle Ear Effusion
Primary: Otoscopic Examination: Auricle and Meatus — 1 ears
Phase 2 N=112 Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media
Acute Otitis Media
Primary: Face, Legs, Activity, Cry, Consolability Scale (FLACC) or Faces Pain Scale Revised (FPS-R) — -4.3; -5.0; -4.6; -4.9 units on a scale
Phase 3 N=370 In-Office Tympanostomy Tube Placement in Children (OTTER)
OME - Otitis Media With Effusion · AOM - Acute Otitis Media
Primary: Procedural Success: — 103; 91 Participants
Phase 3 N=501 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes
Otitis Media
Primary: Number of Subjects With Post-surgical Otorrhea — 383; 118 Participants
Phase 2 N=75 OTO-201 for the Treatment of Otitis Externa
Otitis Externa
Primary: Otoscopic Examination: Tympanic Membrane — 6; 8; 8 Participants
Phase 3 N=326 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children
Acute Otitis Media
Primary: Effectiveness of Viscous-adherent Xylitol Syrup in Reducing Episodes of Clinically-diagnosed Acute Otitis Media — 66.9; 63.3 percentage of particpants — p=0.6
N/A N=40 Lactobacillus Rhamnosus GG in the Middle Ear and Adenoid Tonsil
Upper Respiratory Infection · Acute Otitis Media
Primary: Lactobacillus Rhamnosus GG in Middle Ear Effusion and Adenoid Tonsil — 4; 1 Samples — p=0.05
N/A N=22 Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto)
Acute Otitis Media · Acute Otitis Externa
Primary: Number of Antibiotic Prescriptions — 140; 115; 6; 7 Emergency department encounters
Phase 4 N=41 Treatment of Clogged Tympanostomy Tubes: An Off-Label Use of Dornase Alfa (Pulmozyme®)
Otitis Media
Primary: Patency of the Tympanostomy Tube at the Day-14 Visit. — 8; 11; 15; 12 Ear — p=.36
N/A N=52 Osteopathic Otitis Media Research Study
Otitis Media With Effusion
Primary: Change in Middle Ear Effusion Over Four Weeks Following an Episode of Acute Otitis Media — 26; 16; 12; 22 Ears — p=0.02
Phase 2 N=69 A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis
Acute Otitis Externa
Primary: Adverse Events (AEs) — 10; 3; 6; 1 participants
Phase 2 N=65 Dose-Ranging Study for Miconazole Oil for Treatment of Otomycosis
Otomycosis
Primary: Primary Efficacy Endpoint — 1; 3; 1 Participants
N/A N=99 Safety and Effectiveness of an Auricular Spray
Excessive Ear Wax
Primary: Skin Irritation — 0.22; 0.20; 0.13; 0.11 score on a scale
N/A N=70 Tympanostomy Tube Placement in Children in the Office (Inova Study)
Otitis Media
Primary: Number of Participants With Procedural, Serious, and Device-Related Adverse Events — 0 participants
N/A N=25 Singapore Tympanostomy Tube Delivery System Study
Otitis Media
Primary: Percentage of Ears Treated Successfully With the TTDS in the Absence of Acute Intraprocedural Adverse Events. — 94.6 percentage of ears