Phase 4 N=60 ECT Pulse Amplitude and Medial Temporal Lobe Engagement
Major Depressive Disorder
Primary: Depression Severity — 22.5; 12.0; 14.1 score on a scale — p=0.04
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=13 Nonconvulsive Electrotherapy: a Proof-of-concept Trial
Depressive Disorder · Bipolar Disorder · Schizoaffective Disorder
Primary: Change in Score on the 17-item Hamilton Depression Rating Scale — -11.6 units on a scale — p=0.001
Phase 4 N=138 Enhancing the Effectiveness of Electroconvulsive Therapy in Severe Depression
Depression
Primary: Hamilton Depression Rating Scale (HDRS) — 29.5; 30.4; 12.5; 11.1 units on a scale — p=<0.05
Phase 2 N=39 Electroconvulsive Therapy in Clozapine Refractory Schizophrenia
Schizophrenia
Primary: Response Rates in the ECT Plus Clozapine Group vs the Pharmacotherapy Group. — 50; 0 Percentage of responders
N/A N=41 Electroconvulsive Therapy Amplitude Titration
Major Depressive Disorder
Primary: Beta Coefficient From Linear Regression of Amplitude-determined Seizure (Independent Variable) and Ebrain (Dependent Variable) — -.0001054 beta coefficient from linear…
Phase 3 N=17 Focal Electroconvulsive Therapy for Depression
Major Depressive Disorder
Primary: Remission Based on HDRS, Hamilton Depression Rating Scale, 24 Item. — 5 Participants
N/A N=14 Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia
Depression · Delirium · Seizures
Primary: Change in Cognitive Function During Recovery: Rate of Recovery — 3.5; 6.3; 24.7; 9.7 inverse hours — p=0.016
Phase 3 N=403 ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)
Treatment Resistant Depression · Electroconvulsive Therapy · ECT
Primary: Number of Participants With Treatment Responses Based on the 16-item Quick Inventory of Depressive Symptomatology-Self-Report Scale (QIDS-SR-16) — 70; 108 Participants…
Early Phase 1 N=11 EEG Characteristics in ECT
Electroconvulsive Therapy · Direct Current Electroencephalogram · Ketamine
Primary: Number of Participants Assessed for Clinical Efficacy of ECT — 11 Participants
N/A N=20 The Effect on Cognition of Terminating ECT Induced Seizures With Propofol
Major Depression
Primary: Wechsler Memory Scale-III (WMS-III) Auditory Delayed Index
Phase 4 N=31 Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
Unipolar Depression · Bipolar Depression
Primary: Hamilton Rating Scale for Depression (HRSD) Improvement — 7.82; 8.60 HRSD units
N/A N=45 Optimal Dose of Succinylcholine and Rocuronium for Electroconvulsive Therapy (ECT)
Neuromuscular Blockade · ECT
Primary: Optimal Dose of Neuromuscular Blocking Agent During ECT — 0.85; 0.41 mg.kg-1
N/A N=11 Memantine to Reduce Neurocognitive Deficits Following Unilateral ECT for the Treatment of a Major Depression
Depressive Disorder, Major
Primary: Memantine Effect on CVLT Long Term Recall After Right Unilateral ECT Treatment. — 10.17; 6.67 units on a scale — p=0.006
Phase 3 N=41 Focal Electrically-Administered Seizure Therapy (FEAST) Studies at Two Enrolling Sites to Further Test and Refine the Treatment
Depression
Primary: Percentage Change in Depressive Symptoms as Assessed by Hamilton Rating Scale for Depression — 60.83; 61.81 percentage of change in score
N/A N=11 Mifepristone Treatment for Patients With Non-psychotic Major Depressive Disorder Receiving Bilateral ECT
Depression
Primary: Hamilton Depression Rating Scale Score — 28.5; 23.0; 20.5; 19.0 units on a scale
N/A N=38 Ketamine Anesthesia in Electroconvulsive Therapy
Depression
Primary: Mean Depression Rating Using the Hospital Anxiety and Depression Scale (HADS) — 22.08; 24.45 units on a scale — p=0.171
Phase 2 N=18 Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adults
Depression · Major Depressive Episode · Bipolar Disorder
Primary: Hamilton Rating Scale for Depression, 24-Item (HRSD-24) — 22.625; 15.375 units on a scale
Phase 3 N=39 The Use of Galantamine HBr (Reminyl) in Electroconvulsive Therapy: Impact on Mood and Cognitive Functioning
Major Depression · Bipolar Depression · Schizoaffective Disorder
Primary: Number of Side Effects — 19; 13 Number of reported side effects
N/A N=33 Safety and Efficacy of Electroconvulsive Therapy (ECT) for Behavioural and Psychological Symptoms of Dementia (BPSD)
Dementia
Primary: Change in Neuropsychiatric Inventory (NPI) — -32.79 units on a scale
N/A N=239 Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for Depression
Depression · Unipolar Depression · Treatment Resistant Depression
Primary: Remission of Depression on the Hamilton Rating Scale for Depression-24 Item (HRSD-24) — 25; 30 Participants
N/A N=96 Preventing Relapse After Successful Electroconvulsive Therapy for Depression
Major Depressive Disorder (MDD)
Primary: Relapse Rate — 7; 9 Participants — p=0.014
Phase 3 N=18 A Pilot Study of Creatine Monohydrate as an Augmenting Agent for ECT in Persons With Major Depressive Disorder
Major Depressive Disorder
Primary: HAMD-17 — 16.4; 16.2 score on a scale
N/A N=12 Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression
Treatment Resistant Depression · Major Depressive Disorder · Severe Depression
Primary: Hamilton Depression Rating Scale (HAMD-17) at Last Infusion — 13.74; 14.97 score on a scale — p=0.72
Phase 4 N=99 Pre-medication With Alfentanil vs Placebo During ECT
Blood Pressure · Electroconvulsive Therapy
Primary: Systolic Blood Pressure Change — 22.011; 38.908 mmHg
N/A N=10 The Efficacy of Cranial Electrostimulating Therapy for Depression and Anxiety Among Homeless Adults
Depression · Anxiety
Primary: Depressive Symptoms — 13.00; 6.50 units on a scale
N/A N=20 Investigation on the Value of Bilateral Index (BIS) Monitoring for Magnetic Seizure Versus Electroconvulsive Therapy
Depression
Primary: Recovery Time — 3.0; 6.7 minutes
Early Phase 1 N=6 Ketamine for Depression Relapse Prevention Following ECT
Depression
Primary: Completion Rate for Randomised Treatment — 0; 0 Participants
N/A N=6 Cranial Electrotherapy Stimulation (CES) Therapy
TBI · Anxiety · PTSD
Primary: PCL-5 (Post Traumatic Stress Disorder Checklist for the Diagnostic and Statistical Manual of Mental Disorders) for Use in Treating PTSD Symptoms — 44.25 scores on a scale
Phase 2 N=20 Cranial Electrotherapy Stimulation in Burned Patients
Post Traumatic Stress Disorders · Burns
Primary: Mean Post-Traumatic Stress Questionnaire-Military (PCL-M) Score — 53.8; 56.7; 48.8; 50.4 Score
Phase 2 N=44 Comparison Of Rocuronium Reversal By Sugammadex To Succinylcholine For Electroconvulsive Therapy (ECT)
Neuromuscular Blockade
Primary: Recovery Time of T1 to 90% Baseline — 6.79; 10.97 minutes