Phase 1 N=5 Topical Bethanechol for Improvement of Esophageal Dysmotility
Esophageal Dysmotility
Primary: Distal Contractile Integral — 178.3; 272.3; 261.8 mmHg*s*cm
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=50 Study of the Efficiency of Esophageal Dilation on Patient With Eosinophilic Esophagitis
Suspected Eosinophilic Esophagitis
Primary: Percent Change From Baseline in Dysphagia Score in Patients With Eosinophilic Esophagitis (EE) — 69; 79 Percent Change
Early Phase 1 N=30 Long Term Effect of Buspirone on Esophageal Function and Esophageal Symptoms in Patients With Systematic Sclerosis (SSc)
Systemic Sclerosis
Primary: Changes From Baseline in Manometric Parameters: i) Amplitude of Contractions at the Distal Part of the Esophagus and ii) Resting and Residual (Lower Esophageal Pressure)…
N/A N=26 Outcomes of Esophageal Self Dilation for Benign Refractory Esophageal Stricture Management
Esophageal Dilation · Refractory Benign Esophageal Stricture
Primary: Number of Endoscopic Interventions — 12; 11; 12; 7 endoscopies
N/A N=109 Mechanisms and Management of Infant Dysphagia
Dysphagia · Airway Aspiration · Airway Penetration
Primary: Number of Participants With Successful Safe Oral Feeding — 51; 31 Participants — p=0.008
N/A N=10 Buspirone for Functional Dysphagia
Functional Dysphagia · Ineffective Esophageal Motility
Primary: Change in Distal Contractile Index (DCI) on High Resolution Esophageal Manometry — 241.9; 340.4 mm Hg
Phase 2 N=18 Treatment of Dysphagia Using the Mendelsohn Maneuver
Stroke · Dysphagia
Primary: Change in Duration of Superior Hyolaryngeal Movement — .213; .233 seconds
N/A N=30 Mucosal Impedance and Eosinophilic Esophagitis
Eosinophilic Esophagitis
Primary: Esophageal Mucosal Impedance (MI) — 1457; 3463; 4225; 1713 Ohms
Phase 3 N=80 Gastroesophageal Reflux Treatment in Scleroderma
Gastroesophageal Reflux Disease · Systemic Sclerosis · Scleroderma
Primary: Changing Severity of Heart Burn of SSc Related Omeprazole Resistant GERD Evaluated by Visual Analogue Score (VAS) — 17.9; 17.2 VAS (100)
Phase 3 N=51 The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
Eosinophilic Esophagitis · Gastroesophageal Reflux Disease · EE
Primary: Histological Response to Treatment — 11; 16; 7; 12 Participants — p=1.00
N/A N=20 Magnetically Controlled Capsule Endoscopy Feasibility Study in Gastric Motility
Gastroparesis · Dyspepsia
Primary: Frequency of Contractions at Baseline — 20; 24.6; 23.7 stomach contractions/minute
N/A N=22 Cytosponge and Dietary Therapy in EoE
Eosinophilic Esophagitis
Primary: Histological Remission by Sponge Cytology — 13 Participants
N/A N=21 Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis
Eosinophilic Esophagitis
Primary: Measurement of Eosinophilic Degranulating Protein Concentration — 456.5 ng/mL
Phase 3 N=318 A Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved
Eosinophilic Esophagitis (EoE)
Primary: Number of Participants With Histologic Response at the Final Treatment Period Evaluation (Week 16) — 1; 113; 104; 100 Participants — p=<0.001
N/A N=40 Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction?
Chest Pain Atypical Syndrome
Primary: Mean Change in Esophageal Length With Acid — -0.40; -0.39 centimeters
N/A N=44 An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter
Gastroesophageal Reflux Disease
Primary: To Evaluate the Incidence of All Adverse Events at Various Time Points. — 29 participants
Phase 4 N=20 Esophageal Food Impaction
Esophageal Food Bolus Obstruction
Primary: Patients Condition at Discharge — 2; 15 Participants
Phase 2 N=14 Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)
Sensitivity in Esophagus
Primary: Time to Visual Analogue Scale 7 (VAS7) During Thermal Stimulation at 1.5 Hours Post-Dose. — 84.0; 86.9 seconds
N/A N=20 Treatment of Dysphagia by Using a Synchronized Electrical Stimulation Device
Deglutition Disorders
Primary: Pressure and Timing Change of Velopharynx, Tongue Base, Low Pharynx and Upper Esophageal Sphincter. — 162.04; 129.66; 200.90; 170.66 mmHg — p=< 0.05
N/A N=16 Endoscopic Peroral Myotomy for Treatment of Achalasia
Achalasia
Primary: Treatment Success Defined as Symptom Relief 3 Months After Treatment Based on an Eckhardt Score ≤ 3 — 1.4; 8.8 Eckardt Score — p=<0.001
N/A N=3 Pilot Study to Image the Esophagus Using a SECM Tethered Endoscopic Capsule
Healthy · Barrett's Esophagus · Gastric Acid Reflux
Primary: Feasibility for Imaging of Esophagus Using an SECM Tethered Endoscopic Capsule. — 3 Participants
N/A N=7 Physiology of GERD and Treatment Response
GERD
Primary: Change in GERD Symptoms — 0.6; -1.7 units on a scale — p=0.41
N/A N=191 Cytosponge Adequacy Study Evaluation II
Barrett's Esophagus · GERD
Primary: Procedure Preference and Acceptability Questionnaire and Visual Analog Scale — 7.2; 8.5; -1.3; 16.2 Units on a scale
Phase 4 N=35 Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosive GERD
Gastroesophageal Reflux Disease
Primary: Number of Gastroesophageal Refluxes — 42.4 refluxes — p=0.000002
N/A N=68 Experimental Study to Determine the Effects of Human Refluxate on Macrophage Phenotype and Its Correlation With GERD
Gastroesophageal Reflux Disease (GERD)
Primary: The Number of Reflux in GERD Patients — 33.6; 42.8; 81.0; 53.1 episodes — p=0.002
N/A N=374 The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Department
Gastroesophageal Reflux
Primary: The Primary Symptom of GERD in Chinese Outpatients in Gastroenterology Department — 19; 30; 42; 23 Participants
N/A N=56 Study to Image the Esophagus Using the OFDI Capsule
Barrett's Esophagus · Eosinophilic Esophagitis
Primary: Feasibility of OFDI Imaging in Subjects Swallowing the OFDI Capsule — 56 Participants
N/A N=24 Correlates of GERD Symptom Severity
GERD
Primary: Association of Change in Patient's GSR From Beginning to End of Study Visit With GERD Symptom Severity 2 Weeks Later — -0.94; -1.70 micro-Siemens — p=0.034
N/A N=48 Evaluation of the Gastrointestinal Manifestation of Fabry's Disease
Fabry's Disease
Primary: Gastric Emptying Transit Time Measured Via SmartPill Study — 2.9; 2.8 Hours
N/A N=227 Novel Pharyngeal Metrics to Predict Dysphagia Outcomes
Dysphagia · Swallowing Disorders
Primary: pHRM Pressure Change (Pharyngeal) — 381; 395; 389; 402 mmHg·s·cm