N/A N=40 Is Non-Cardiac Chest Pain Caused by Sustained Longitudinal Smooth Muscle Contraction?
Chest Pain Atypical Syndrome
Primary: Mean Change in Esophageal Length With Acid — -0.40; -0.39 centimeters
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=50 Study of the Efficiency of Esophageal Dilation on Patient With Eosinophilic Esophagitis
Suspected Eosinophilic Esophagitis
Primary: Percent Change From Baseline in Dysphagia Score in Patients With Eosinophilic Esophagitis (EE) — 69; 79 Percent Change
Phase 2 N=92 Magnesium for Peroral Endoscopic Myotomy
Esophageal Spasm
Primary: Esophageal Symptoms Questionnaire Score (ESQ) — 24; 35 score on a scale
Phase 4 N=20 Esophageal Food Impaction
Esophageal Food Bolus Obstruction
Primary: Patients Condition at Discharge — 2; 15 Participants
Early Phase 1 N=30 Long Term Effect of Buspirone on Esophageal Function and Esophageal Symptoms in Patients With Systematic Sclerosis (SSc)
Systemic Sclerosis
Primary: Changes From Baseline in Manometric Parameters: i) Amplitude of Contractions at the Distal Part of the Esophagus and ii) Resting and Residual (Lower Esophageal Pressure)…
N/A N=26 Outcomes of Esophageal Self Dilation for Benign Refractory Esophageal Stricture Management
Esophageal Dilation · Refractory Benign Esophageal Stricture
Primary: Number of Endoscopic Interventions — 12; 11; 12; 7 endoscopies
Phase 2 N=14 Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD)
Sensitivity in Esophagus
Primary: Time to Visual Analogue Scale 7 (VAS7) During Thermal Stimulation at 1.5 Hours Post-Dose. — 84.0; 86.9 seconds
N/A N=44 An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter
Gastroesophageal Reflux Disease
Primary: To Evaluate the Incidence of All Adverse Events at Various Time Points. — 29 participants
Phase 1 N=5 Topical Bethanechol for Improvement of Esophageal Dysmotility
Esophageal Dysmotility
Primary: Distal Contractile Integral — 178.3; 272.3; 261.8 mmHg*s*cm
Phase 2 N=119 OBS in Adolescent and Adults With EOE: A Phase II, Randomized, Double-Blind, Placebo Controlled, Study With an Open Label Extension
Eosinophilic Esophagitis (EoE)
Primary: Percent of Participants Who Were Histologic Responders — 2.6; 38.8 percent of participants — p=<0.0001
N/A N=1 Esophageal Fully Covered Metal Stents in Caustic Strictures Study
Refractory Benign Esophageal Strictures Caused by Caustic Ingestion
Primary: Clinical Success — 1 Participants
N/A N=16 Endoscopic Peroral Myotomy for Treatment of Achalasia
Achalasia
Primary: Treatment Success Defined as Symptom Relief 3 Months After Treatment Based on an Eckhardt Score ≤ 3 — 1.4; 8.8 Eckardt Score — p=<0.001
Phase 4 N=16 Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis
Eosinophilic Esophagitis
Primary: Peak Esophageal Eosinophil Count — 57.3; 71.3 Peak # of eosinophils counted per field
N/A N=21 Use of Esophageal String Test to Understand Symptoms, Inflammation, and Function in Eosinophilic Esophagitis
Eosinophilic Esophagitis
Primary: Measurement of Eosinophilic Degranulating Protein Concentration — 456.5 ng/mL
N/A N=42 Fluticasone Versus Esomeprazole to Treat Eosinophilic Esophagitis
Eosinophilic Esophagitis
Primary: Number of Participants Who Responded — 7; 4 participants
N/A N=18 WallFlex Esophageal Fully Covered (FC) Benign Anastomotic Stricture
Refractory Anastomotic Esophageal Strictures
Primary: Number of Dilation Procedures — 5.4; 2.4 Dilation procedures — p=0.159
Phase 3 N=51 The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
Eosinophilic Esophagitis · Gastroesophageal Reflux Disease · EE
Primary: Histological Response to Treatment — 11; 16; 7; 12 Participants — p=1.00
N/A N=3 Pilot Study to Image the Esophagus Using a SECM Tethered Endoscopic Capsule
Healthy · Barrett's Esophagus · Gastric Acid Reflux
Primary: Feasibility for Imaging of Esophagus Using an SECM Tethered Endoscopic Capsule. — 3 Participants
Phase 2 N=42 Topical Steroid Treatment for Eosinophilic Esophagitis
Eosinophilic Esophagitis
Primary: Number of Participants With Complete Response to Dysphagia — 9; 6 participants — p=0.74
N/A N=22 Cytosponge and Dietary Therapy in EoE
Eosinophilic Esophagitis
Primary: Histological Remission by Sponge Cytology — 13 Participants
N/A N=175 Early Detection and Treatment of Esophageal Injury After Catheter Ablation for Atrial Fibrillation
Atrial Fibrillation
Primary: Incidence of Esophageal Injury as Assessed by Endoscopy — 1; 12; 4; 0 participants
N/A N=6 Using Spectrally Encoded Confocal Microscopy (SECM) to Visualise the Esophagus Using an SECM Probe
Barrett's Esophagus
Primary: Number of Participants With Tolerability of the Procedure — 6 Participants
N/A N=95 Treatment of Extraesophageal Reflux With the Reza Band UES Assist Device
Laryngopharyngeal Reflux
Primary: Percent Change in the Reflux Symptom Index (RSI) at 4 Weeks — -54.3 Per Cent Change — p=<0.05
N/A N=56 Study to Image the Esophagus Using the OFDI Capsule
Barrett's Esophagus · Eosinophilic Esophagitis
Primary: Feasibility of OFDI Imaging in Subjects Swallowing the OFDI Capsule — 56 Participants
Phase 3 N=318 A Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved
Eosinophilic Esophagitis (EoE)
Primary: Number of Participants With Histologic Response at the Final Treatment Period Evaluation (Week 16) — 1; 113; 104; 100 Participants — p=<0.001
Phase 2 N=27 TLESR-impedance Study in Patients
Reflux Episodes
Primary: Number of Transient Lower Esophageal Sphincter Relaxations (TLESRs) 0-3 Hours Post Meal, Post Third Dose — 11.6; 15.5 Relaxations
N/A N=156 Non-endoscopic Brushing of the Esophagus Using a Non-endoscopic Inflatable Balloon of the Esophagus in Screening for Barrett Esophagus
Barrett Esophagus
Primary: Number of Participants Reporting Each Category of Tolerance Assessed by the Tolerance Survey — 96; 31; 1; 121 number of participants
N/A N=47 Esophageal Deviation in Atrial Fibrillation Ablation
Atrial Fibrillation
Primary: Number of Participants With a Minimum Distance of 1 cm Esophageal Deviation Between the Ablation Line for the Ipsilateral Pulmonary Vein (PV) Pairs and the Trailing Edge…
N/A N=93 Capsule Endoscopy for Post-Ablation Esophageal Lesion Assessment
Esophageal Lesion
Primary: Number of Participants With Esophageal Lesions Identified Using Capsule Endoscopy — 15 Participants
Phase 2 N=30 A Pilot Study of the Treatment of Eosinophilic Esophagitis With Omalizumab
Esophagitis
Primary: Change in Eosinophil Numbers Per High Power Field Proximally and Distally Between Baseline and Post-treatment and Between Both Groups — 0.6; -7.5 perecentage of eos per…