Clinical Trial Search

Primary: Change in Worry Severity From Baseline to Post-intervention as Measured by the Penn State Worry Questionnaire (PSWQ) — 62.43; 6.19 units on a scale (PSWQ) — p=<0.005

Primary: Breathing Focus Task -Negative Intrusions — 2.85; 2.55; 2.45; 2.26 score on a scale — p=.93

Primary: Change in Worry-related Sleep Disturbances — -4; -1 units on a scale

Primary: Clinician's Severity Rating (CSR) Scale of Anxiety Disorders Interview Schedule for DSM-IV (ADIS-IV) — 5.5; 3.14; 2.43 units on a scale

Primary: Penn State Worry Questionnaire - A (PSWQ-A) at 6 Months — 26.73; 26.25; 22.04; 23.04 units on a scale — p=0.77

Primary: Change in Percent of Correct Button Presses During Threat Compared to the Safe Condition (AAST) — -0.016; 0.008 Percentage of accurate responses

Primary: General Anxiety Disorder-7 (GAD-7) — 15.4; 14.7; 11.6; 12.0 score on a scale

Primary: Penn State Worry Questionnaire - Measure of Symptom Change — 42.1; 55.8 score on a scale — p=<0.05

Primary: Transdiagnostic Repetitive Negative Thinking (Measured by the Perseverative Thinking Questionnaire [PTQ]) Assessed in Phase I (Pilot Trial) and Group Differences…

Primary: Changes From Baseline in Penn State Worry Questionnaire (PSWQ-A) at Week 13 — -9.44; -5.37 units on a scale

Primary: Change in Hamilton Anxiety Rating Scale Score — -6.4 units on a scale

Primary: Change in HAM-A Total Score — -12.9; -15.7; -12.5 Units on a Scale — p=0.6540

Primary: Change in Linguistic Interpretation Bias as Assessed by the Word-sentence Association Paradigm for Youth (WSAP-Y) — 19.77; 47.40 score on a scale

Primary: Psychometric Scores — 16.4; 18.86; 27.6; 24.3 units on a scale

Primary: Change in Modified Dental Anxiety Scale — 19.5; 19.6; 15.4; 17.6 units on a scale — p=<0.05

Primary: Frost Multidimensional Perfectionism Scale (FMPS)- Concern Over Mistakes Subscale — 36.54; 35.76; 30.97; 35.71 units on a scale

Primary: Change From Baseline in Hamilton Anxiety Rating Scale (HAM-A) Total Score at Visit 7 (Day 42) — -9.01; -8.93 Score on scale

Primary: Comparisons of End of Study HAM-A Score Means for Sertraline 50 mg vs Placebo, Sertraline 100 mg vs Placebo, and Sertraline 50 mg vs. Sertraline 100 mg — 10.638; 10.008…

Primary: Hamilton Anxiety Rating Scale (HAM-A) — 25.9; 23.8; 20.9; 19.4 units on a scale — p=.17

Primary: Pediatric Anxiety Rating Scale — 7.79; 15.06 units on a scale

Primary: High End State Function — 56.52; 43.48; 56.52; 47.62 % people meeting high endstate status

Primary: For Aim1: Baseline Generalized Anxiety Disorder Symptoms as Measured by the Generalized Anxiety Disorder - 7 Item Scale (GAD-7). — 12.85; 11.62 units on a scale — p=.088

Primary: Active Symptoms of Generalized Anxiety Disorder — 13.65; 16.27 units on a scale

Primary: Anxiety Disorders Interview Schedule for DSM-IV — 5.23; 5.09; 3.18; 5.14 score on a scale

Primary: Change From Baseline in the Hospital Anxiety and Depression Scale (HADS) Anxiety Subscale Score at Endpoint — 12.76; 13.56; -6.38; -5.29 Units on a scale — p=0.006

Primary: Clinical Global Impression Scale-I (CGI-I) — 3.65; 3.81; 3.86; 4.05 units on a scale

Primary: Change in Pediatric Anxiety Rating Scale (PARS) Severity Score — -6.38; -7.81 score on a scale — p=0.0281

Primary: Percent Change in Body Weight — 10.9; 9.6 percentage change

Primary: Change in the Hamilton Rating Scale for Anxiety (HAM-A) Total Score — -10.1; -10.4; -10.8; -9.5 Units on scale

Primary: Mean Number of Drinks Consumed Per Week — 40.82; 29.62; 12.12; 23.86 Standard Drinking Units per Week — p=0.002