N/A N=129 Efficacy of Two Sonic Toothbrushes in Reducing Extrinsic Tooth Stain
Tooth Bleaching
Primary: Lobene Stain Index of Stain Intensity Scores 4 Weeks After Toothbrush Use — 0.89; 0.88; 1.13 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=123 A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices
Oral Hygiene
Primary: Change From Baseline in Overall Macpherson Modification of the Lobene Stain Index (MLSI) at 8 Weeks. — -0.32; -0.47; -0.38; -0.40 Score on a scale — p=0.6499
N/A N=86 Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate
Tooth Bleaching
Primary: Lobene Stain Index of Stain Extent Scores 4 Weeks After Dentifrice Use — 1.35; 1.64 score on a scale
N/A N=227 A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal
Tooth Stain
Primary: Lobene Stain Index Composite Score at Day 15 — 2.568; 1.909; 1.575 units on a scale — p=<0.001
N/A N=220 Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices
Extrinsic Dental Stain · Oral Hygiene
Primary: Overall Modified Lobene Stain Index (MLSI) Mean Score at Week 4 — 1.38; 1.43; 1.42; 1.38 Score on a scale — p=0.2681
N/A N=160 A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching
Dentin Sensitivity · Oral Hygiene
Primary: Adjusted Mean VITA Shade Score at 24 Weeks After Tooth Bleaching — 12.00; 12.06 score on a scale — p=0.9141
N/A N=279 Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks
Oral Hygiene
Primary: Change From Baseline in Mean Total Modified Lobene Stain Index (MLSI) Score at Week 8 — -2.33; -2.42; -0.38 score on a scale — p=<0.0001
N/A N=80 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Caries Infiltration · Fluorosis · Dental Care
Primary: Esthetic Changes — 1.90; 5.50; 5.53; 5.35 score on a scale
Phase 4 N=160 An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
Oral Hygiene
Primary: Modified Lobene Stain Index (MLSI) at Week 6 — 0.97; 1.22 Score on a Scale — p=0.1313
N/A N=120 Clinical Evaluation of Enamel Microhardness Using Tooth Whitening Agents
Dental Atraumatic Restorative Treatment
Primary: Enamel Hardness — 348.4; 351.6; 354.5 Vickers hardness kg f/mm2 — p=0.231
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
N/A N=57 Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar Incisor Hypomineralization · Dental Caries · Hypomineralization of Enamel
Primary: Clinical Outcome Based on Success After Intervention on MIH Affected Molar at 6 Months — 17; 18; 17 number of Successful MIH affected molars
Phase 3 N=19 Investigation of Dental Plaque and Gingival Index
Dental Plaque
Primary: Gingival Margin Plaque Index — 15.4; 12.81 Units on a scale — p=0.05
Phase 2 N=36 Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
Tooth Erosion
Primary: Adjusted Mean Percent Net Erosion Resistance (NER) of Enamel Specimens Exposed to Test Dentifrice + Test MR Relative to: 1) Test Dentifrice+ Sterile Water Rinse 2)…
Phase 2 N=20 Experimental Dentifrice Remineralization/Fluoride Uptake in an in Situ Model
Dental Erosion
Primary: Percentage Surface Micro-hardness Recovery (SMHR) of Enamel Specimens — 39.46; 38.31; 36.17; 17.26 % SMHR — p=0.7756
N/A N=135 Evaluate the Effectiveness of an Experimental Urethane Dimethacrylate Resin Based Dental Composite Material
Dental Caries · Restorative Material
Primary: Percent of Teeth With Anatomic Form Graded as A or B. — 42; 37; 40; 2 teeth — p=0.2552
N/A N=16 Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
Dental Caries
Primary: Change in Mineral Density Determined by the Canary Caries Detection System — 23.424; 31.125; 35.563 Canary Number — p=0.0003
Phase 4 N=83 Enamel Remineralization Potential of Dentifrices in Situ
Dental Caries
Primary: Percentage Surface Microhardness Recovery (%SMHR) of Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and SnF/NaF Toothpaste (1450ppmF) — 40.94; 17.88 Percentage of…
N/A N=45 Efficacy of Three Toothpastes Using an in Situ Caries Model
Dental Caries
Primary: Percentage Surface Microhardness Recovery (SMHR) of Phyte (0% 0.425% and 0.85%) at 2 Weeks — 25.53; 26.81; 7.41; 28.88 % SMHR — p=0.7603
N/A N=29 Intra Oral Kinetics of Fluoride Containing Dentifrices
Tooth Erosion
Primary: Concentrations of Fluoride Ions in Saliva 60 Minutes Post Brushing Prior to Administration of the Orange Juice or De-ionised Water Rinse — 0.23; 0.23; 0.15 parts per…
Phase 3 N=65 In Situ Caries Model of Fluoride Toothpastes
Caries
Primary: Percent Surface Microhardness (SMH) Recovery of Enamel Specimens Exposed to NaF Toothpaste (1426ppmF) and AmF Toothpaste (1400ppmF) — 38.05; 41.06 Percentage SMHR…
Phase 3 N=57 In Situ Caries Efficacy of Fluoride Toothpastes
Caries
Primary: Percentage Surface Microhardness Recovery (%SMHR) of Sound Enamel Specimens Exposed to NaF Toothpaste (1450ppmF) and NaF Toothpaste (1400ppmF) — 28.31; 26.32 Percentage…
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
N/A N=62 The Effect of Experimental Dentifrices on Remineralization of Caries Lesions In-situ
Oral Hygiene
Primary: Percentage Surface Microhardness Recovery (% SMHR) — 32.49; 31.81; 27.56; 22.62 Percentage of SMHR — p=<0.0001
N/A N=56 Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion
Dental Erosion · Acid Wear
Primary: Relative Erosion Resistance (RER) of Enamel Specimens Post 4 Hours of Treatment Exposure — -36.66; -36.53; -36.98; -77.82 Percentage RER — p=<0.0001
Phase 4 N=108 Combined Bleaching Technique: Efficacy and Tooth Sensitivity
Tooth Bleaching · Tooth Sensitivity
Primary: Tooth Sensitivity (TS) — 1; 1; 1; 0 score on a scale
N/A N=50 Nobio Clinical Study - Demineralization Prevention With a New Antibacterial Restorative Composite
Dental Caries · Denture, Partial, Removable
Primary: Mineral Loss ΔZ — 235; 774 vol% * μm]
Phase 4 N=57 The Efficacy of Stabilized Chlorine Dioxide Rinse as a Chemical Adjuvant for Treatment of Per-implant Mucositis
Peri-implant Mucositis
Primary: Global Probing Depth — 2.37; 2.64 mm — p=0.28
Phase 4 N=41 Evaluation of Aerosol in a Dental Clinic
Covid19
Primary: Number of Bacterial Colony Forming Units (CFUs) — 47.2; 125.3; 70.7; 116.7 bacterial colony forming units (CFUs)
Phase 3 N=315 Effect of pH and Fluoride Concentration of Dentifrices on Caries Control
Dental Fluorosis · Dental Caries
Primary: Evaluation of the Concentration of Fluoride Incorporated Into the Biofilm Done 6 Months After Initiation of Dentifrices Use. — 0.80; 1.32; 1.74 mmol/kg — p=<0.05