Phase 3 N=59 Impact of Intraoperative Fluid Management on Electrolyte and Acid-base Variables
Anesthesia
Primary: Change in Base Deficit — -1.5; -1.2; -0.5 mEq/L
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=82 Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
Septic Shock · Fluid Therapy · Hypotension
Primary: Cumulative Fluid Administered — 4417; 4110 mL of study fluid
N/A N=30 LifeFlow Fluid Study- Non- Critical Pediatric Patients Having a Trans Abdominal Ultrasound
Dehydration in Children · Dehydration
Primary: Duration- Ultrasound Ordered to Completed — 154.4; 114.8 minutes
N/A N=150 Traditional vs Oral Fluid Management in Total Knee Arthroplasty
Arthroplasty, Replacement, Knee
Primary: Body Weight — -1.9; -1.6 pounds
Phase 3 N=167 Maintenance Intravenous Fluids in Children
Hyponatremia
Primary: Incidence of Hyponatremia (Defined as Serum Sodium Less Than 130 mmol/L) — 1; 2; 8 participants — p=<0.05
N/A N=40 Closed-Loop Fluid Administration System Using Hemodynamic Monitors
Intraoperative Volume Status · Postoperative Complications
Primary: Fluid Status During Surgery — 95 percentage of case time
N/A N=3,000 REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery
Major Abdominal Surgery
Primary: Number of Participants With Disability-free Survival — 1232; 1223 Participants
N/A N=3,000 REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery: RELIEF Study
Abdominal Surgery
Primary: Disability-free Survival — 165; 172 Participants
Phase 4 N=170 Fluid Balance Study in Sick Neonates
Very Low Birth Weight Infant
Primary: Duration of Admission at the Ward in Days — 9; 8 number of days — p=<0.05
Phase 3 N=135 Clinical Trial of Standard Versus Goal-Directed Perioperative Fluid Management (GDT) for Patients Undergoing Liver Resection
Liver Cancer
Primary: Postoperative Complications — 42; 45; 24; 24 Participants
N/A N=68 Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
Intracranial Aneurysm · Brain Edema · Scoliosis
Primary: Number of ICU Stays Greater Than 1.5 Days — 13; 20 Number of ICU Stays greater that 1.5 Day
Phase 3 N=1,389 Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis
Cerebral Edema · Diabetic Ketoacidosis
Primary: the Number of Participants With Glasgow Coma Score (GCS) < 14 Within the First 24 Hours of Treatment for Diabetic Ketoacidosis (DKA) — 10; 11; 11; 16 Participants — p=0.34
Phase 3 N=45 Furosemide and Albumin for Diuresis of Edema: A Pilot Randomized Controlled Trial
Edema · Hypoproteinemia
Primary: Ventilator-free Days — 4; 13 days
N/A N=10,100 Indication for Intraoperative Volume Therapy
Patients Undergoing Any Kind of Surgery
Primary: Number of Different Substitution Solutions Administered — 7827; 1055; 221 participants
Phase 4 N=337 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
Acute Respiratory Failure · Intubation Complication
Primary: Number of Participants With Cardiovascular Collapse — 33; 31 Participants
N/A N=974 Isotonic Solution Administration Logistical Testing
Acute Kidney Injury
Primary: Proportion of Isotonic Crystalloid Which is 0.9% Saline — 91.2; 21.0 Percentage of fluid that was saline — p=0.001
Phase 4 N=157 Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation
Fluid Loss · Symptom Complex, Triple · Emergencies
Primary: Quality of Recovery-40 Score at 24 Hours — 166.8; 164.4 units on a scale — p=0.608
N/A N=66 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children
Hyponatremia
Primary: Serum Sodium Levels in Both Groups — 137.8; 140.0 mEq/L — p=0.04
Phase 4 N=40 Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach
Hypotension · Kidney Injury
Primary: Development of Renal Injury — 0.8; 0.74 mg/dL — p=0.31
Phase 2 N=30 Fluid Chloride and AKI in Cardiopulmonary Bypass
Acute Kidney Injury
Primary: Change in [TIMP2]*[IGFBP7] Biomarker — 0.015; 0.009 (ng/mL)^2/1000
Phase 4 N=57 Loop Diuretics Administration and Acute Heart Failure
Acute Heart Failure
Primary: Evaluation of Mean Urine Output Volume During the Infusion Period — 2505; 2140 mL — p=0.04
N/A N=64 Fluid Management in Transient Tachypnea of the Newborn
Transient Tachypnea of the Newborn
Primary: Duration of Respiratory Support — 45; 42 hours
N/A N=119 Optimal Fluid Resuscitation for Trauma Patients
Trauma
Primary: Mortality — 0 participants
N/A N=30 A Randomized Controlled Trial of a Conservative Fluid Balance Strategy for Patients With Sepsis and Cardiopulmonary Dysfunction (BALANCE Study)
Sepsis
Primary: ICU-free Days to 14 Days After Enrollment — 9; 11 days
Phase 2 N=81 Bolus of Saline in Stroke
Ischemic Stroke
Primary: The Percentage of Change in Optical Cerebral Blood Flow (oCBF) During Bolus Normal Saline Compared to Baseline, as Measured by Diffuse Correlation Spectroscopy (DCS)…
N/A N=150 Fluid Responsiveness Evaluation in Sepsis-associated Hypotension
Sepsis · Hypotension
Primary: Fluid Balance — 0.65; 2.02 Liters — p=0.021
Phase 4 N=1,554 The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial
Septic Shock
Primary: 90-day Mortality — 323; 329 Participants
Phase 3 N=50 Intravenous Fluid Therapy for the Treatment of Emergency Department Patients With Migraine Headache
Migraine Headache
Primary: Verbal Pain Score at 60 Minutes — 4.5; 4.9 units on a scale (0-10)
N/A N=60 Fluid and Nutrition in Elective Hip Surgery
Hip Surgery Corrective
Primary: Change in Insulin Sensitivity (Percent) — -43; -38; -51 percent change of insulin sensitivity
Phase 3 N=258 Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Hyponatremia · Hypernatremia
Primary: Hospital Acquired Acute Plasma Sodium Derangements (Hypo- or Hypernatremia)