30 closest matches · ranked by relevance
Gastroesophageal Reflux
Primary: Determination of Median Time to Sustained Partial Response as Defined by Reduction in Likert Severity Scale Used to Assess Pain Associated With Heartburn in the Patient…
Heartburn
Primary: Measure: Number of Participants With no Heartburn (Post Treatment) Following Consumption of Heartburn-inducing Meal — 0; 2; 1; 0 participants
Heartburn
Primary: Time-to-onset of Heartburn Relief — 30.0; 60.0 Minutes — p=<0.0480
Heartburn
Primary: Percentage of Heartburn Free 24 Hour Days During 14 Days of Randomized Treatment — 43.32; 29.44 Percentage
Heartburn
Primary: Percentage of Heartburn Free 24 Hour Days During 14 Days of Randomized Treatment — 46.79; 30.93 Percentage of heartburn free days
Gastroesophageal Reflux Disease · Dyspepsia
Primary: Change From Baseline in Reflux Disease Questionnaire (RDQ) Scores for the GERD Dimension — -1.27; -1.06 score on a scale — p=<0.0001
Gastroesophageal Reflux
Primary: The Primary Symptom of GERD in Chinese Outpatients in Gastroenterology Department — 19; 30; 42; 23 Participants
Heartburn
Primary: Complete Heartburn Relief During the First Full 24-Hour Period in Intent-to-Treat (ITT) Population — 100; 121 Participants
Non-Erosive Gastro-Esophageal Reflux Disease · Heartburn
Primary: Percentage of Days Without Daytime or Nighttime Heartburn — 27.7; 44.8; 44.4 Percentage of days — p=<0.0001
Heartburn
Primary: Complete Heartburn Relief During the First Full 24-Hour Period in the ITT Population. — 114; 163 participants — p=<0.001
Gastro-oesophageal Reflux
Primary: The Number of Patients With Complete Resolution of Heartburn by Week 4 — 272; 302; 278 participants — p=<0.05
Heartburn
Primary: Number of Participants With Relief of 24 Hour Heartburn and Without Relief of 24 Hour Heartburn — 7; 10; 0; 9 participants
Gastroesophageal Reflux Disease (GERD) · Heartburn · Dyspepsia
Primary: Safety - Number of Participants Experiencing a Serious Adverse Event — 0; 0; 0; 0 participants
Gastroesophageal Reflux Disease
Primary: Change in Frequency of Days With Heartburn From Baseline to 8 Weeks of Treatment — -3.44 Days per week with symptoms
Gastroesophageal Reflux Disease
Primary: Percentage of Patients With Relief of Nighttime Heartburn During the Last 7 Days of the Study. — 34.3; 10.4 Percentage of participants
Gastro-esophageal Reflux Disease
Primary: TRPV1, GDNF, and NGF mRNA Expression of Esophageal Mucosa — 1.14; 3.25; 2.33; 1.39 Fold change
Asthma · Lung Diseases · Lung Diseases, Obstructive
Primary: Episodes of Poor Asthma Control (EPAC) From Diary Cards, According to Definition That Did Not Include Use of Beta-agonists as a Criterion — 2.3; 2.5 events per person…
Heartburn
Primary: Change in the Frequency of Heartburn During the 7-day Period Prior to the 8 Week Visit (Visit 3) Compared to the Frequency of Heartburn During the 7-day Period Prior to…
Heartburn · Gastroesophageal Reflux Disease
Primary: Percentage of Days With Neither Daytime Nor Nighttime Heartburn During Treatment — 32.67; 51.72 percentage of days — p=0.057
Gastroesophageal Reflux Disease
Primary: Change From Baseline in Percent Regurgitation-Free Days Over Weeks 5-8 — 36.96; 43.01; 44.37; 38.79 percentage of days — p=0.128
Gastroesophageal Reflux Disease (GERD)
Primary: Number of Participants With at Most One Day With Not More Than Mild Intensity of the Symptoms 'a Burning Feeling Behind the Breastbone' and 'Unpleasant Movement of…
Non-Erosive Gastro-Esophageal Reflux Disease · Heartburn
Primary: Percentage of Evaluable Heartburn Episodes Completely Relieved Within 3 Hours and With No Further Heartburn Reported for 24 Hours After Taking Study Drug — 56.0; 60.6…
Gastroesophageal Reflux Disease · GERD · Reflux Esophagitis
Primary: Change in the Frequency of Heartburn During the 7-day Period Prior to the 8 Week Visit (Visit 3) Compared to the Frequency of Heartburn During the 7-day Period Prior to…
Gastroesophageal Reflux Disease
Primary: Percentage of Time During the 4-hour Post-dosing Period With pH Below pH 4 — 5.14; 14.94 percentage of time with pH below pH 4 — p=0.0003
Gastroesophageal Reflux Disease · Obesity
Primary: Gastroesophageal pH — 7.3; 6.6; 3.7; 4.9 percent time ph < 4 in 24 hrs
Pharmacodynamic
Primary: Change in Gastric pH After Administration of Betaine Hydrochloride (HCl) — 4.54 units on a scale
GERD
Primary: Association of Change in Patient's GSR From Beginning to End of Study Visit With GERD Symptom Severity 2 Weeks Later — -0.94; -1.70 micro-Siemens — p=0.034
Non-erosive Gastroesophageal Reflux Disease
Primary: The Percent Time With pH <4.0 During 24 Hour Esophageal pH Monitoring at the End of the Observation Period (Predose Monitoring) and at the End of the Treatment Period…
Indigestion
Primary: Percentage of Participants With Satisfactory Relief of Non-ulcer Dyspepsia Symptoms — 71; 34; 82; 56 percentage of participants
Sensitivity in Esophagus
Primary: Time to Visual Analogue Scale 7 (VAS7) During Thermal Stimulation at 1.5 Hours Post-Dose. — 84.0; 86.9 seconds