30 closest matches · ranked by relevance
Hyponatremia
Primary: Change in Serum Sodium From Baseline to the 48 Hour Assessment or Study Drug Discontinuation. — 126.03; 126.39; 125.55; 130.4 mEq/L — p=0.028
Hyponatremia · Euvolemia · Hypervolemia
Primary: Number and Severity of Infusion Site Reactions (ISRs) Using a Modified ISR Reporting Scale for Phlebitis and Infiltration in Patients Treated With Dose Regimen 1 and…
Hyponatremia
Primary: Hospital Acquired Hyponatremia — 10; 11; 1 participants
Heart Failure
Primary: Median Urine Output at 24 Hours Post Randomization — 2910; 3150 mL
Hyponatremia
Primary: Incidence of Hyponatremia (Defined as Serum Sodium Less Than 130 mmol/L) — 1; 2; 8 participants — p=<0.05
Syndrome of Inappropriate Antidiuretic Hormone Secretion
Primary: Percentage of Subjects With Normalized Serum Sodium Concentration on the Day After Final IMP Administration — 43.8; 80; 80; 85.7 percentage of participants
Hyponatremia
Primary: Change in Sodium Levels — 139.9; 138.1; 138.1; 138.2 mEq/L — p=0.030
Advanced Cancers
Primary: Participants Whose Serum Sodium Concentration Corrected to at Least 135 mEq/L on Day 14 — 16; 1 participants
Hyponatremia · Premature
Primary: Hyponatremia — 6; 1 Participants — p=0.71
Intra-dialytic Hypotension
Primary: Change in Intra-dialytic Decline in Systolic Blood Pressure — 26; 23 mm Hg
Hyponatremia
Primary: Participants With Adverse Events (AEs) — 105; 76; 73; 19 participants
Hyponatremia · Hypernatremia
Primary: Hospital Acquired Acute Plasma Sodium Derangements (Hypo- or Hypernatremia)
Heart Failure Acute
Primary: Total Natriuresis After 24 Hours — 409; 345 mmol
Hyponatremia
Primary: Change From Baseline in the Neurocognitive Composite Score of Speed Domains (NCS-SD; Sum of All Correct Speed Domain Z-Scores) — 0.20; 0.39 Z-score — p=0.08
Acute Heart Failure · Diuretics Drug Reactions
Primary: Mortality, Days in Hospital & Decongestion — 54.68; 44.16 % wins — p=0.357
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
Primary: Maximal Increase From Baseline in Serum Sodium Concentration Following Tolvaptan Administration. — 3.6; 5.3; 7.9 mmol/L
Postural Orthostatic Tachycardia Syndrome
Primary: Plasma Volume — 2805; 3032; 2362; 2633 mL
Postnatal Growth Disorder
Primary: Change in Somatic Growth (Weight) — 0.04; 0.16 score on a scale — p=0.162
Hypertension
Primary: Change in Tissue Sodium Concentration Measured Using Sodium Magnetic Resonance Imaging (NaMRI) — -0.202; 0.430; -1.745; -0.407 mmol/L
Salt Sensitivity of Blood Pressure
Primary: Functional Connectivity Between the Subfornical Organ and Organum Vasculosum of the Lamina Terminalis (Z-score) — 0.258490; 0.359145; 0.207372; 0.169055 z-score
Heart Failure
Primary: Weight Change Over 48 Hours — -4.6; -5.8; -4.1 kg
Stroke · Intracranial Hypotension · Cerebral Edema
Primary: Number of Subjects With Tissue Damage — 0 Participants
Hyponatremia · Syndrome of Inappropriate ADH (SIADH) Secretion
Primary: Change in Sodium Levels From Start of Treatment With Tolvaptan Until Hospital Discharge — 10.3 mmol/L
Congestive Heart Failure
Primary: Change in Body Weight at 48 Hours — -3.3; -0.8 pounds — p=0.094
Anesthesia
Primary: Change in Base Deficit — -1.5; -1.2; -0.5 mEq/L
Hyponatremia
Primary: Serum Sodium Levels in Both Groups — 137.8; 140.0 mEq/L — p=0.04
Heart Failure
Primary: Change in Blood Volume — -320; -447 mL — p=0.56
Acute Heart Failure
Primary: Evaluation of Mean Urine Output Volume During the Infusion Period — 2505; 2140 mL — p=0.04
Hypertension
Primary: 24-hour Urinary Sodium Excretion — 220.58; 198.73; 177.40; 146.18 mmol/24 hours
Coronary Artery Disease · Edema
Primary: Extravascular Lung Water Index — 9; 8; 9; 8 mL/kg