Clinical Trial Search

Primary: Percent Changes in Endothelial Function as Measured by Flow Mediated Dilation by 2D Doppler Ultrasound on Day 2 — 2; 7 percentage of change

Primary: Cerebral Blood Flow — 1.7; 1.3 percentage of signal intensity change

Primary: Number of Participants With Hypoglycemia (Blood Sugar Level <70 mg/dl — 11 Participants

Primary: Insulin Sensitivity — 3.37*10^-4 1/min per uU/mL

Primary: Maximum Epinephrine Response (LBGI Groups) — 495; 217 pg/ml

Primary: Glucose (mg/dL) — 56.5; 52.8; 55.0; 52.8 mg/dL

Primary: Change Between Pre and Post Challenge Glucose Variability — 0.51; 1.62; 3.71; 0.97 score on a scale

Primary: Glucagon (pg/mL) — 76; 74; 53; 56 pg/mL

Primary: The Frequency of Hypoglycaemic Episodes With Sitagliptin vs Placebo Treatment. — 5.35; 5.72 Hypoglycaemic episodes

Primary: Change From Baseline in Cardiovascular Autonomic Function — -16.00; -16.59 ms/mmHg

Primary: Psychomotor Speed — 48.7; 56.6 score on a scale

Primary: Hypoglycemia Incidence — 53; 10 participants — p=<0.001

Primary: Number of Hypoglycemic Events ≥50 mg/dl 15 Minutes AND ≥ 70 mg/dl 30 Minutes After Initial Treatment — 58; 53 Hypoglycemic Events — p=0.99

Primary: Peak Epinephrine Levels — 609 pg/mL

Primary: Proportion of Participants With Captured Hypoglycaemia — 3 Participants

Primary: Number of Subjects With Clinically Meaningful Reduction in Glucose Infusion Rate (Double-Blind) — 2; 0 Participants

Primary: Glycemic Control — 10.7; 10.9 mmol/L — p=0.677

Primary: Continuous Glucose Monitor (CGM) Glucose Total Area Over the Curve and Less Than 60 mg/dl — 1015; 4375.68 mg/dl/min

Primary: Glucagon Response to Acute Hypoglycaemia — 1.33; 1.0; 1.33 pmol/L — p=1.0

Primary: Diurnal Level 2 Hypoglycemia Events (ADA, <54 mg/dL) as Measured by CGM in Patients With Severe Hyperinsulinemic Hypoglycemia (HH) — 5.2; 5.2; 2.7; 2.1 events per 14…

Primary: Neonatal Hypoglycemia — 3; 15 neonates

Primary: Area Under the Curve for Glucose Above Baseline — 0.623; 0.59; 0.03 mg/kg glucose per mcg glucagon

Primary: Percentage Change in Area Under The Curve (AUC) for Blood Glucose 0-2 Hours — 301.09; 258.66; 248.63; 274.13 mmol x min/L — p=0.1146

Primary: Time to Achieve Glycemic Control — 225 Minutes

Primary: Blood Glucose Nadir — 128; 189; 162 mg/dl

Primary: Glycemic Response During Exercise and Early Recovery — 86; 85; 174; 161 mg/dL — p=<0.001

Primary: Fear of Hypoglycemia — 54.3; 58.7; 35.29; 49.0 units on a scale

Primary: Glucagon Counterregulation to Hypoglycemia — 16.0; 16.5 pmol/l

Primary: Number of Participants With Meal-provoked Hypoglycemia, Defined as Sensor Glucose <65 mg/dL — 1; 5 participants — p=0.103

Primary: Serious Adverse Events — 0; 0; 0 events