Clinical Trial Search

Primary: Change From Baseline at Week 6 in Caregiver-rated Aberrant Behavior Checklist Irritability (ABC-I) Subscale Score — -9.6; -11.2; -11.2 score on a scale — p=0.2986

Primary: Mean Change From Baseline to Week 8 in Aberrant Behavior Checklist - Irritability (ABC-I) Subscale Score — -10.1; -8.87 score on a scale — p=0.4597

Primary: Number of Participants With Treatment-emergent Adverse Events (TEAEs) Graded By Severity, Serious TEAEs and Trial Discontinuation Due to TEAEs — 23; 24; 15; 19…

Primary: Change From Baseline in Aberrant Behavior Checklist Irritability Subscale (ABC-I) — -12; -7 units on a scale — p=.44

Primary: Clinical Global Impressions-Improvement — 1.8 units on a scale

Primary: Change in Score on Conners Adults Attention Deficit Hyperactivity Disorder (ADHD) Rating Scale — 68.6; 71.8; 53.4; 57 T-score

Primary: The Effects of rTMS on Reciprocal Social Awareness — 68; 79.667; 64.2; 74 total raw score (higher=worse)

Primary: Clinical Global Impression Improvement (CGI-AD) — 3.83; 4.25; 2.67; 4.25 score on a scale

Primary: Number of Participants With Improvement on the Clinical Global Impression-Improvement (CGI-I) Scale — 3; 1 Participants

Primary: Children's Yale-Brown Obsessive Compulsive Scale Modified for Autism Spectrum Disorder (CY-BOCS-ASD) - Total Score — 14.81; 14.60; 14.94; 15.71 Score on a Scale

Primary: Change From Baseline in Anxiety Severity on the Pediatric Anxiety Rating Scale After 16 Weeks of Treatment. — 3.43; 3.47; 3.28; 2.13 units on a scale

Primary: Percentage of Participants Randomized — 100; 100 percentage of participants randomized

Primary: Efficacy of Intranasal Oxytocin vs. Placebo on Measures of Social Function — -2.43; -3.06; -1.34; -3.03 units on a scale

Primary: Spatial Attention Baseline — 80.3; 43.0 Percent Correct

Primary: Change From Baseline in the Pervasive Developmental Disorder-Behavioral Inventory (PDDBI) - Autism Composite Score — -4.5; -6.4 units on a scale — p=0.5

Primary: Change in Ohio Autism Clinical Impressions Scale - Improvement (OACIS-I) Average Score From Baseline — 0.28; 0.28; 0.28; 0.33 score on a scale

Primary: Pediatric Anxiety Rating Scale. — 11.62; 14.04 units on a scale — p=.04

Primary: Change in ASD Symptoms Social Responsiveness Scale 2 (SRS-2) Scale. — -30.6 scores on a scale

Primary: Maximum Tolerated Dose (MTD) — 0.40 IU / kg

Primary: Reading the Mind in the Eyes Task (RMET) — 18.07; 18.08; 17.86; 18.09 total raw score

Primary: Social Responsiveness Scale-2 (SRS-2) Total Score at Baseline — 75.6; 72.6 T-score — p=0.331

Primary: Pediatric Anxiety Rating Scale (Measures the Severity of Anxiety Symptoms) — 16.33; 17.62; 11.58; 16.05 units on a scale

Primary: Change in ASD Symptoms Social Responsiveness Scales 2 (SRS-2) Scales From Baseline to Week 8 — -32.4 scores on a scale

Primary: Change From Baseline in Brain Activity During Task (Task-based fMRI) After a Single Dose of Nasal Spray — 0.11; -0.26; -0.15; -0.16 Change-from-baseline (BOLD response)

Primary: Percentage of Patients Relapsing by Week 16 — 32; 50 Percentage of participants — p=0.097

Primary: Change From Baseline in Aberrant Behavior Checklist-Irritability at 12 Weeks — 7.6; -0.6 units on a scale

Primary: Change in Aberrant Behavior Checklist Irritability (ABC-I) Subscale — -3.5; -7.4; -12.4 units on a scale — p=<0.001

Primary: Change in Maladaptive Behaviors — -6.62; -1.08 units on a scale

Primary: Change in Gastrointestinal (GI) Module of the Pediatric Quality of Life Inventory (PedsQL) at From Baseline at Week 8 — 17.97; 7.98 Units on a scale

Primary: Aberrant Behavior Checklist--Community (ABC-C) Irritability Subscale Scores — 14.0; 18.50 score on a scale — p=0.12