30 closest matches · ranked by relevance
Ketamine-Induced Brain Activity Changes · Psychotic-like Symptoms
Primary: Ketamine-Induced Brain Activity in Regions of Interest During Resting State — 0.4954; 0.2943; 0.4439; 0.3876 percent signal change in brain activity — p=0.259
Anesthesia
Primary: Average Pain Intensity Pre- and Post-Ketamine Induction — 7.9; 1.6; 4.1; 4.3 score on a scale
Major Depressive Disorder
Primary: Synaptic Density — 2.40; 2.32 Ratio
Depression · Anxious Depression · Major Depressive Disorder
Primary: Change in Hamilton Depression Rating Scale (HDRS) From Baseline/Minute 0 to 4 Hours Post-infusion. — -9.625 score on a scale — p=<0.01
Depression
Primary: Montgomery Asberg Depression Scale — 19.72; 22.87; 23.51 score on a scale — p=.0004
NMDA Receptor Function
Primary: Percent Change in Amelioration of Ketamine-related Task Activation as Measured by Functional Magnetic Resonance Imaging in Inferior Parietal Lobule — -0.17; -0.094…
Healthy Volunteers
Primary: Change in The Profile of Mood States - Bipolar Version (POMS - Bi) Composed-Anxious Subscale — -6.8; -11.9 score on a scale
Treatment Resistant Depression
Primary: Cortical Excitability in the Dorsolateral Prefrontal Cortex (DLPFC) as Assessed by Transcranial Magnetic Stimulation-evoked Activity Detected by Electroencephalography…
Anesthesia
Primary: Frequencies At Which Changes in Alpha, Theta, and Slow-Delta Wave Power Were Observed From Baseline During Sevoflurane-induced General Anesthesia — 10; 5; 1 Hz
Cognitive Disorders · Delirium · Acute Kidney Injury
Primary: Number of Patients With Postoperative Cognitive Dysfunction — 16; 10 Participants — p=0.23
Major Depressive Disorder
Primary: Number of Responders 24-hours Post-ketamine Infusion — 3; 1; 3; 2 participants
Depression · Mood Disorders · Major Depresssion
Primary: MADRS Score - Baseline — 1.17; 1.48; 33.83; 31.82 units on a scale
Depression · Delirium · Seizures
Primary: Change in Cognitive Function During Recovery: Rate of Recovery — 3.5; 6.3; 24.7; 9.7 inverse hours — p=0.016
Mechanical Ventilation · Airway Patency · Respiratory Depression
Primary: Inspiratory Airflow — 0.36; 0.47; 0.44 L/s
Alcoholism
Primary: Biphasic Alcohol Effects Scale (BAES) - Subscale Sedation — 0.63; 0.96; 0.71; 1.25 units on a scale
Depression
Primary: Mean Depression Rating Using the Hospital Anxiety and Depression Scale (HADS) — 22.08; 24.45 units on a scale — p=0.171
Major Depressive Disorder
Primary: Hamilton Depression Rating Scale - Suicidal Ideation (HDRS-SI) — 1.6; 1.6 units on a scale
Depression
Primary: Completion Rate for Randomised Treatment — 0; 0 Participants
Psychoses, Substance-Induced
Primary: Brief Psychiatric Ratings Scale (BPRS) Positive Symptom Subscale Score — 0.00; 0.00; 1.40; 1.00 Scale of 0-6
Unipolar Depression · Bipolar Depression
Primary: Hamilton Rating Scale for Depression (HRSD) Improvement — 7.82; 8.60 HRSD units
Primary Alcohol Use Disorder
Primary: Relapse Rates — 13; 15; 14; 18 Participants
Depression · Suicide
Primary: MADRS Total Score at Baseline and Last Acute Phase Observation — 29.4; 29.4; 29.4; 15.9 units on a scale — p=<0.01
Depression
Primary: Evaluate the Effects of Ketamine on Depressive Symptomatology by Measuring Change in Score on the Montgomery-Asberg Depressive Rating Scale — 28.82; 25.20 units on a scale
Major Depressive Disorder · Post-Traumatic Stress Disorder (PTSD)
Primary: Change in Glutamate Levels at Baseline and After Ketamine Administration as Confirmed by Positron Emission Tomography (PET) Imaging — 19; 14; 31; 14 percentage reduction
Major Depressive Disorder · Suicidal Ideation
Primary: Change in Scale for Suicidal Ideation — -3.66; -8.62 units on a scale
Cocaine Dependence
Primary: Change in Cue Reactivity — 126; 18; 16 units on a scale (0-200), high is worse
Treatment Resistant Depressive Disorder
Primary: Percentage of Participants Demonstrating at Least a 50% Reduction on Montgomery-Asberg Depression Rating Scale Scores — 0; 2; 8; 6 Participants
Depression · Anxiety · Post Traumatic Stress Disorder
Primary: 9-item Patient Health Questionnaire (PHQ-9) — -3.23 units on a scale
Tinnitus
Primary: GABA and Glutamate (Glx) Levels in the Auditory Cortex Derived From 3T Magnetic Resonance Spectroscopy — 2.11; 2.12; 2.09; 2.03 Ratio — p=0.05
Major Depressive Disorder (MDD) · Treatment Resistant Depression (TRD)
Primary: MADRS — 14.77; 22.72 units on a scale