Clinical Trial Search

Primary: Percent Change in Estimated Glomerular Filtration Rate (eGFR) From Baseline to 6 Months — -8.5; -8.4 % change from preoperative eGFR

Primary: Whole Blood Platelet Aggregation to 0.5 Millimoles Arachidonic Acid — 21.0; 18.0; 0; 0 ohms

Primary: Variability of Tacrolimus Blood Levels Measured by DBS Over Time — 2.635 ng/ml

Primary: Glomerular Filtration Rate at Baseline — 56; 67 mL/mnt/1.73 m^2

Primary: Overall Response Rate — 72; 35 Percentage of participants

Primary: iGFR at the End of the Wash-out Period — 61.2; 61.2 ml/min/1.73 m^2 — p=0.999

Primary: Stone Clearance — 76 participants

Primary: Number of Participants With Live Kidney Donor Activation Events — 87; 86; 88; 5 Participants

Primary: Stone Clearance Rate Defined as the Kidney Stone Surface Area Measured by Pre-operative Computed Tomography (CT) Scan Divided by the Time to Remove the Targeted Stone…

Primary: The Discrete Incidence of Any of the Chronic Kidney Disease Patient Safety Indicators (CKD-PSIs) Endorsed by the Consensus Expert Panel — 108.7; 100.6; 38.3; 41.2 events…

Primary: The Rate of Allograft Rejection — 0; 0 participants

Primary: Delta Curve Between Calculated GFR and GFR Measured by Iohexol at Baseline — 91.5; 88.3; 93.6; 90.0 ml/min/1.73m2 — p=<0.05

Primary: 24-hour Urinary Sodium Excretion — 93; 119 mmol/day

Primary: Change in the Gastrointestinal Symptoms Rating Scale (GSRS) to 24 Months — -0.04; -0.11 score on a scale — p=0.50

Primary: Pharmacokinetics (PK) - Area Under the Plasma Concentration-time Curve (AUC) — 298; 640; 702 ng*h/mL