N/A N=28 HYBRID: Hydrogen Breath Test in Lactose Digestion
Lactose Intolerance
Primary: Log of First Postprandial Peak Change of Hydrogen Concentration — 1.21; 1.10; 3.38; 3.59 log(ppm) — p=0.0801
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=24 Effect of Lactose on Blood Lipids
Cardiovascular Risk Factor · Lipaemia · Metabolic Disease
Primary: Postprandial Changes in Plasma Triglyceride Concentrations — 51; 90; 98 mmol/L x 360 min
Phase 4 N=50 A Preference Study Comparing Kristalose® and Liquid Lactulose
Constipation
Primary: Patient Preference in Terms of Overall Preference and Preference of Taste, Consistency, and Portability. — 7; 6; 12; 11 participants
N/A N=53 Congenital Sucrase-Isomaltase Deficiency (CSID) Genetic Prevalence Study (GPS)
Congenital Sucrase-isomaltase Deficiency (CSID)
Primary: Prevalence of CSID Genetic Variants — 27; 0 Participants
Phase 2 N=24 Fermented Milk Drink on Human Intestinal Microflora
Signs and Symptoms, Digestive
Primary: Modification of the Composition of the Intestinal Microflora: Bifidobacterium — 7.88; 7.60; 8.13; 8.10 log10 CFU/g — p=<0.05
N/A N=43 Clinical Utility of Handheld Hydrogen Breathalyzer in Identification of Food Sensitivities (AIRE Study)
SIBO · Small Bowel Bacterial Overgrowth Syndrome
Primary: Hydrogen Content in Parts Per Million (Ppm) — 3.5 ppm
N/A N=26 Survival of the Probiotic Lacticaseibacillus Paracasei Strain Shirota (LcS) in the GI Tract of Healthy Adults
Healthy
Primary: Change in Live LcS Numbers From Baseline (Day 14) to the End of the Ingestion Period (Day 28). — 2.14; 5.27 Log 10 CFU/g Feces
N/A N=94 Lcr35 for Children With Functional Constipation
Constipation
Primary: Number of Participants With Treatment Success (≥3 Spontaneous Defecations Per Week With no Fecal Soiling — 24; 28 Participants — p=0.399
Phase 2 N=54 Effects of Carbohydrate in Diet and Supplements on the Gastrointestinal Tolerability of LIK066
Obesity
Primary: Number of Episodes of Diarrhea (Part A and Part B) — 1.67; 1.25; 0.38; 1.88 Number of stools — p=0.202
Phase 3 N=224 B. Lactis HN019 for Functional Constipation
Constipation
Primary: Whole Gut Transit Time
N/A N=36 Antihypertensive Effect of Fermented Milk With Lactococcus Lactis on Prehypertensive Subjects
Hypertension
Primary: Systolic Blood Pressure Measurements — 131.8; 134.3; 122.1; 127.4 mmHg — p=<0.05
N/A N=288 Prebiotic GOS and Lactoferrin With Iron Supplements
Iron-deficiency
Primary: Ratio of Harmful to Beneficial Bacterial Genera in Fecal Microbiota as Determined by Quantitative Polymerase Chain Reaction (qPCR) at 1 Month — 2.208; 1.530; 2.075…
Phase 2 N=32 Efficacy and Safety of Bisacodyl and Lactulose as a Preparation for Colonoscopy
Colonoscopy Preparation
Primary: Efficacy of Bisacodyl and Lactulose as a Preparation for Colonoscopy. — 5.7; 7.4; 7.8 units on a scale
Phase 2 N=40 2 Regimens of Lactulose for Colonoscopy Preparation in Adults
Colonoscopy Preparation
Primary: Efficacy of Lactulose as a Preparation for Colonoscopy. — 8.2; 7.2; 7.5; 8.4 units on a scale
N/A N=50 Safety, Tolerability, and Biosignature of Humanized Prebiotics in Healthy Adults
Intestinal Health
Primary: Mean Composite PROMIS Maximum Scores — 4.3; 5.0; 3.0; 4.4 score on a scale
Phase 2 N=170 Study of Milk Allergy and Tolerance in Children
Food Hypersensitivity · Milk Hypersensitivity
Primary: Number of Participants With a Positive Progression in Tolerance of Baked Milk and Ultimately Unheated Milk in Dose Escalation Sub-arm Compared to Maintenance Sub-arm…
N/A N=11 Effect of Milk Oligosaccharides and Bifidobacteria on the Intestinal Microflora of Children With Autism
Autism
Primary: Stool Microbiota Composition Change During Prebiotic Only Treatment — 2; 3; 1; 0 Participants
N/A N=48 Effects of Low FODMAP Diet on Colonic Epithelial Physiology in Diarrhea-predominant Irritable Bowel Syndrome
Irritable Bowel Syndrome
Primary: Lactulose Mannitol Excretion — 512.5; 394.5; 456.8; 411 micrograms per ml
N/A N=12 Glycemic Response Testing
Glycemic Index · Glycemic Response
Primary: Glycemic Response Measured as the Positive Incremental Area Under the Time-concentration Curve(iAUC) Calculated From Individual Glucose Measurements Upon Consumption of…
N/A N=30 Obesity - Inflammation - Metabolic Disease: Effect of Lactobacillus Casei Shirota
Metabolic Syndrome
Primary: Change of Neutrophil Phagocytosis From Baseline to 3 Months — 0.06; 3.48 percentage of monocytes and granulocytes
N/A N=82 Intergenerational Transmission of Low-calorie Sweeteners Via Breast Milk
Breastfeeding
Primary: Baseline Sucralose Concentration in Breast Milk — 0.19 ng/ml
N/A N=30 Effect of Lactobacillus Rhamnosus GG (LGG) on Infant Colic
Colic · Inflammation
Primary: Daily Average Crying and Fussing Duration According to Barr Diary Records — 111; 133 minutes