Phase 3 N=251 Low Dose Aspirin for Venous Leg Ulcers
Venous Leg Ulcer
Primary: Time to Complete Healing of Reference Ulcer — 77; 69 days — p=0.246
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=228 Dose Finding Study of HP802-247 in Venous Leg Ulcers
Venous Leg Ulcer · Venous Stasis Ulcers
Primary: The Average Percent (%) Change From Baseline in the Target Wound Area in Each Treatment Group Over the Twelve-week Double-blind Treatment Period. — -77.11; -70.15…
N/A N=81 Effects of Non Contact Low Frequency Ultrasound in Healing Venous Leg Ulcers
Venous Insufficiency · Venous Reflux · Lower Extremity Ulcer
Primary: Wound Area Mean Percent Reduction — 45.8; 61.6 percentage of mean area reduction — p=<0.024
Phase 3 N=155 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers >12 cm2 to ≤ 36 cm2
Venous Leg Ulcers
Primary: Wound Closure — 17; 23 participants
Phase 2 N=29 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study
Ulcer · Venous Ulcer · Skin Ulcer
Primary: Logarithm of Percentage of Baseline Ulcer Size — 3.6043; 3.5030 Mean of log (percentage of baseline area — p=0.652
N/A N=47 MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers
Varicose Ulcer
Primary: Percentage Change in Wound Area — -39.2; -46.6 percentage change in wound area — p=0.565
N/A N=28 Predictive of Biomarkers of Healing in Chronic Venous Ulceration of the Lower Limb
Varicose Ulcer
Primary: Identification of Biomarkers Predictive of Ulcer Healing. — 9 Number of biomarkers
N/A N=83 Leg Ulcers Standards of Care Enhancement
Venous Leg Ulcer · Mixed Leg Ulcer
Primary: Percentage Change of the Wound Area — 42.41; 60.75; 25.18; 72.16 percentage of change
Phase 2 N=140 Cooling Leg and Foot Ulcer Skin Post Healing to Prevent Ulcer Recurrence
Venous Hypertension Ulcers · Venous Stasis Ulcer · Venous Ulcer
Primary: Number of Participants With Ulcer Recurrence — 6; 3; 11; 5 participants — p=0.091
N/A N=31 VLU Dressing Study
Venous Leg Ulcer
Primary: Change in Bacterial Load — 12678.81; 33190.8 CFU/gram
Phase 2 N=90 Compression Device Versus 4-layer Compression System
Leg Ulcers
Primary: Safety Measured by the Number of Subjects With Adverse Events (Including Any Deterioration of Ulcer) — 33; 47 Number of Subjects with Adverse Events
Phase 2 N=121 Dose-response Relationship Study of S42909 on Leg Ulcer Healing
Venous Leg Ulcer
Primary: Relative Reduction of Reference Ulcer Area After 4 Weeks of Treatment on Top of Standard of Care Compared With Baseline Reference Ulcer Area (W000) Assessed During Study…
Phase 3 N=537 Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers
Venous Leg Ulcer
Primary: Complete Healing of the Study Ulcer by Week 16. — 201; 176 participants — p=0.1030
N/A N=76 Effect of VarIthena on Wound Healing in Venous Leg Ulcers (VLU)
Venous Leg Ulcer
Primary: Change From Baseline in Wound Perimeter — 29.36; 43.64 mm
N/A N=12 A Non-significant Risk Clinical Study of Therapeutic Ultrasound for Patients With Diabetic Foot Ulcers.
Diabetic Foot Ulcer · Peripheral Arterial Disease · Wound; Foot
Primary: Transcutaneous Oxygen Pressure (TcPO2) — 50.96 mmHg
Phase 3 N=447 Study Investigating the Safety and Efficacy of HP802-247 in the Treatment of Venous Leg Ulcers
Venous Leg Ulcers
Primary: Compare the Treatment Groups for the Proportion of Subjects With Complete Wound Closure Over the 12-Week Treatment Period From Baseline — 129; 126; 82; 84 participants…
N/A N=41 Developing Strategies for Effective Debridement in Patients for Venous Leg Ulcers
Venous Leg Ulcer
Primary: Change in the Genetic Profile After Debridement in the Intervention Group. — 1031 Number of Differentially Expressed Genes
N/A N=90 Blu Light for Ulcers Reduction
Leg Ulcers Venous · Dehiscence, Surgical Wound
Primary: Size of Wound Remaining Compared to Initial Wound Size — 42.58; 53.78 percentage of the remaining area
N/A N=68 LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency
Trophic Ulcers · Chronic Venous Insufficiency
Primary: Number of Participants With Trophic Ulcer Healing — 11; 28 Participants
N/A N=52 Effect of Intermittent Pneumatic Compression on Ulcer Healing in Subjects With Secondary Lymphedema
Lymphedema
Primary: Median Time to Wound Closure at 9 Months — 141; 211 median number of days for complete heali
N/A N=8 ULCERS - Electrical Stimulation in Diabetic Foot Ulceration
Diabetes
Primary: Number of Day Until 50% Healing of Leg Ulcer — 55; 30 Days
Phase 2 N=40 Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers
Leg Ulcer · Varicose Ulcer
Primary: Primary Efficacy: Cumulative Proportion of Patients Completely Healed by the End of the Treatment Period, as Judged by the Investigator's Direct Observation. — 1; 4; 3…
N/A N=50 Investigation of the Clinical Performance of Biatain Fiber Ag on Venous Leg Ulcers
Venous Leg Ulcer
Primary: Mean Relative Wound Area Reduction as Indication of Total Wound Healing — 46.3; 43.9 relative wound area reduction (%)
Phase 4 N=201 Evaluating the Efficacy of an Absorbent Foam Dressing Containing Silver (Mepilex Ag) Versus the Same Dressing Without Silver Used on Subjects With Venous Leg Ulcers or Mixed Ulcers
Venous Leg Ulcers · Mixed Leg Ulcers
Primary: Efficacy Will be Defined as Absolute Wound Size Reduction. — -4.65; -5.09 cm2
N/A N=135 Diagnostics in the Leg Ulcer Pathway
Venous Leg Ulcer
Primary: Primary Care Practitioners and the Management of Venous Leg Ulcers. — 50; 34; 45 Participants
N/A N=102 Comparison of the Effectiveness of Two Medical Compression Bandage Application Techniques by Measuring Interface Pressures Depending on Whether or Not the Heel is Included in Patients With Open Venous Ulcers
Venous Ulcer
Primary: Interface Pressure at V3 — 28.4; 30.1 mmHg
N/A N=62 Evaluation of Pain Associated With the Removal of Wound Dressing During Care of Venous Leg Ulcer. Comparison of the Efficacy and Safety of Two Dressings Urgotul and TulleGras
Venous Leg Ulcer
Primary: Pain Intensity at Removal of the Primary Dressing, Evaluated by the Subject Just After Removal — 11.9; 11.7 units on a scale: 0-100 mm
N/A N=28 Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ulcers (VLUs)
Venous Leg Ulcer · Chronic Venous Insufficiency · Venous Stasis Ulcer
Primary: Number of Participants Who Agreed With Tolerance and Comfort Questionnaire Items After Using a Dual Action Pneumatic Compression Device — 12; 8; 9; 15 Participants
N/A N=203 AQUACEL® Ag+ Extra™ and Cutimed™ Sorbact® Dressing in the Management of Venous Leg Ulcers Over a 12-week Period
Venous Leg Ulcer · Diabetic Foot
Primary: Effectiveness of AQUACEL® Ag+ Extra™ and Cutimed® Sorbact® on Wound Management — 80; 60 Number of Wounds
N/A N=60 A RCT Evaluating Efficacy of Type-I Collagen Skin Substitute vs. Human Amnion Membrane in Treatment of Venous Leg Ulcers
Venous Leg Ulcers
Primary: Percentage Wound Area Change — 78.9; 65.4 percentage wound area reduction