30 closest matches · ranked by relevance
Epilepsy · Epilepsy, Generalized · Seizures
Primary: Percent Reduction in Number of Drop Seizures (12-week Maintenance Period). — 41.2; 49.4; 68.3; 12.1 Percent Reduction — p=0.0120
Lennox Gastaut Syndrome
Primary: Part 1: Percent Change From Baseline in the Frequency of Seizures That Result in Drops (ESC-confirmed) in the Combined Titration and Maintenance Period (T+M) in the…
Epilepsy · Epilepsy, Generalized · Seizures
Primary: Percent Reduction in Number of Drop Seizures. — 10.1; 85.2 Percent Reduction — p=<0.0182
Lennox-Gastaut Syndrome
Primary: Number of Seizure After Treatment by tDCS — 80.67; 93.43; 35.53; 93.14 seizures — p=<0.05
Epilepsy · Lennox Gastaut Syndrome
Primary: Percentage Change From Baseline In Drop Seizure Frequency During The Treatment Period — -41.86; -37.16; -17.17 percentage change — p=0.0047
Lennox-Gastaut Syndrome
Primary: Median Percent Reduction in Average Weekly Rate of Drop Seizures Based on the 7-day Assessment — 92.3 percentage of drop seizures
Epilepsy · Lennox-Gastaut Syndrome
Primary: Percentage Change From Baseline In Drop Seizure Frequency During The Treatment Period — -43.90; -21.80 percentage change — p=0.0135
Seizures
Primary: Percentage of Participants With Adverse Events — 88.9; 92.3; 88.2; 90.4 Percentage of participants
Lennox Gastaut Syndrome (LGS)
Primary: Percent Change From Baseline in Major Motor Drop (MMD) Seizure Frequency Per 28 Days During the Full Treatment Period — -6.69; -6.11 percent change — p==0.785
Epilepsy · Dravet Syndrome · Lennox-Gastaut Syndrome
Primary: Number of Participants With Any Treatment-emergent Adverse Event (TEAE) Occurring in ≥5% of Participants in Any Treatment Group — 306; 353; 135; 140 participants
Lennox-Gastaut Syndrome
Primary: Percent Change in Tonic-Atonic Seizure Frequency From Baseline (Per 28 Days) — -24.20; -3.25 Percent Change — p=0.003
Lennox-Gastaut Syndrome
Primary: Child Behavior Checklist (CBCL) Total Problem T-scores at the End of 2-year Treatment Period — 55.7; 54.8 score on a scale — p=0.6928
Epilepsy
Primary: Change in Partial Onset Seizure (POS) Frequency Per 28 Days From Baseline to the Maintenance Period — -1.55; -3.05 Seizures per 28 days — p==0.0003
Lennox-Gastaut Syndrome
Primary: Number of Participants With Adverse Events as a Measure of Safety and Tolerability of Rufinamide — 54; 38; 9; 2 Participants
Epilepsy
Primary: Number of Participants With Serious Adverse Events (SAE) — 177 Participants
Epilepsy
Primary: Number of Study Participants With Treatment-emergent Adverse Events (TEAEs) Over the Duration of the Treatment Period — 222 Participants
Epilepsy With Partial-onset Seizures
Primary: Change in Average Daily Frequency (ADF) of Electrographic Partial-onset Seizures From End-of-Baseline (EOB) Period Video-EEG to End-of-Maintenance (EOM) Period Video-EEG…
Dravet Syndrome · Lennox Gastaut Syndrome · Epileptic Encephalopathy
Primary: Percentage of Participants With Treatment-emergent Adverse Events (TEAEs) — 75.5 percentage of participants
Epilepsy
Primary: Mean Changes in Count of Generalized Spike-wave Discharges on 24-hour Ambulatory Electroencephalogram (EEG) From Visit 2 to Visit 6 — -4.55; -166.22; -203.12 discharges
Epilepsy · Generalized Tonic-Clonic Seizures
Primary: Percentage Change From the Combined Baseline in the Generalized Tonic-clonic Seizure Frequency Per Week Over the 28-week Treatment Period (Dose Adjustment + Evaluation…
Epilepsy
Primary: Number of Subjects That Report at Least One Treatment-emergent Adverse Event During the Study (Approximately 13 Weeks) — 14; 19; 9 participants
Epilepsy
Primary: Time to the Second Primary Generalized Tonic Clonic (PGTC) Seizure During the 24-week Treatment Period From Visit 2 (Week 0) to Visit 10 (Week 24) — 76; 49 events…
Tuberous Sclerosis
Primary: Percent Change From Baseline in 28-day Seizure Frequency Through the End of 12-Week Treatment Period — -16.61 Percent change
Drug Resistant Partial Onset Seizure
Primary: Double Blind: Cohort 2: Percent Change From Baseline in 28-day Seizure Frequency During Titration + Maintenance Period — -21.28; -10.25 Percent change — p=0.1788
Epilepsy
Primary: Change in the Number of Seizure Days With Absence Seizures From the Baseline Phase to the Maintenance Phase — -0.37 number of seizure days
Epilepsy
Primary: Percentage of Participants With Treatment-emergent Adverse Events (TEAEs) — 77.2 percentage of participants
Epilepsy · Dravet Syndrome
Primary: Percentage Change From Baseline In Convulsive Seizure Frequency During The Treatment Period — -38.94; -13.29 percent change — p=0.0123
Partial Epilepsies
Primary: The Proportion of Subjects Who Achieved "Seizure-free Status" During the First 12 Weeks of the Maintenance Phase — 37.5; 14.9 percentage of subjects
Epilepsy · Dravet Syndrome
Primary: Change In Convulsive Seizures During The Treatment Period Compared To Baseline — 48.7; 45.7; 26.9 percentage reduction — p=0.0299
Epilepsy · Generalized Tonic-clonic Seizures
Primary: The Percent Change From the Combined Baseline (4-week Retrospective Baseline and 4-week Prospective Baseline) in the Generalized Tonic-clonic Seizure Frequency Per Week…