N/A N=58 Blue Light Intraocular Lenses (IOLs) and Photostress
Cataract
Primary: Photostress Recovery Time in Seconds. — 36; 41.46; 24.88 seconds
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=36 Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment
Mild Cognitive Impairment · Alzheimer Disease
Primary: Melatonin Levels — 0.89; 0.84; 0.9; 0.68 pg/mL
N/A N=33 Investigating the Effects of Evening Light Exposure on Melatonin Suppression, Alertness and Nocturnal Sleep
Non-visual Photoreception
Primary: Melatonin Suppression — 71.4; 70.1; 54.3; 32.5 Percentage suppression — p=0.73
N/A N=21 Visual Activity Evoked by Infrared in Humans After Dark Adaptation
Age Related Macular Degeneration · Retinitis Pigmentosa · Congenital Stationary Night Blindness
Primary: Visual Perception to Infrared: Mean Minimal Intensity (uW) at Which Participants Could See IR Between 900 - 1400 nm. — 0.671770454; 0.809204; 0.205456012; 0.222247 uW…
N/A N=40 Role of Glare and Spectral Filtering on Contrast Sensitivity: A Pilot Study
Visual Acuity
Primary: Area Under the Curve of Photopic Contrast Sensitivity Function Under Bright Light Conditions (∼120 cd/m2) With a Broadband Glare Source — 1.92; 1.62…
N/A N=15 Blue Blockers at Night and Insomnia Symptoms
Insomnia · Sleep
Primary: Pittsburgh Insomnia Rating Scale-65 (PIRS65) Total Score — 72.64 units on a scale
N/A N=109 Macular Pigment and Glare Disability
Vision, Entoptic
Primary: Macular Pigment Optical Density — 0.54; 0.42 optical density — p=0.01
Phase 3 N=250 Safety and Efficacy of a Violet Visible Light Blocking Intraocular Lens (IOL)
Cataract
Primary: Best Corrected Distance Visual Acuity — 119; 120 participants
N/A N=15 Morning Light Treatment at Home to Reduce PTSD Symptoms
PTSD
Primary: Change in PTSD Checklist for DSM-5 (PCL-5) Scores Over 4 Weeks of Treatment — 15.11; 2.50 units on a scale
N/A N=37 A Photoxicity and Photoallergy Study of a Developmental Face Cream, Serum and Lotion
Skin Care
Primary: Percentage of Participants With Photo-initiated Potential Sensitization Reaction — 0; 0; 0; 0 Participants
Phase 1 N=85 Evaluation of Photosafety of BI 730357 Compared to Placebo and the Known Photosensitizing Agent Ciprofloxacin
Healthy
Primary: Photosensitivity Index at 24 Hours Under Condition 1 (i.e., Under Full Range of UVB/UVA Exposure, Simulating Midday Summer Outdoor Sun Exposure) — 0.93; 1.01; 1.00; 1.04…
N/A N=80 Effects of Blue-light Blocking Lens on Visual Functions
Effects of Blue-light Blocking Lens on Visual Functions
Primary: Contrast Sensitivity as Assessed by Mars Contrast Sensitivity Chart — 1.866; 1.861; 1.856; 1.818 log contrast sensitivity score
N/A N=35 30-Minute Light Exposure for the Treatment of Seasonal Affective Disorder
Seasonal Affective Disorder
Primary: SIGH-ADS Score — 29.4; 25.8; 5.6; 4.5 units on a scale — p=0.74
N/A N=40 Rod Sensitivity in Age-related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP)
Retinitis Pigmentosa · AMD
Primary: Rod Sensitivity Within the Central Retina as Measured on the Nidek MP-3S — 7; 20 Participants — p=<0.05
Phase 1 N=38 Clinical Evaluation of the Phototoxic Potential of Xenaderm Ointment
Healthy
Primary: Skin Reaction Score — 0.4; 0.5; 0.1; 0.4 units on a scale
N/A N=68 Functional Vision With ACRYSOF® IQ IOLs Blue Light Filtration
Cataract
Primary: Change in Braking Reaction Time From No-glare to Glare — 0.07; 0.15 seconds
N/A N=94 Opioid Sparing Potential of Light-Induced Analgesia
Pain
Primary: Change in Pain Level — 1.15; -0.04; 1.07 score on a scale
Phase 1 N=59 Clinical Evaluation of the Photoallergy Potential of Xenaderm Ointment
Healthy
Primary: Frequency Distribution of Skin Irritation Scores — 39; 10; 3; 0 Scores on a scale
N/A N=26 Mechanisms of Light-based Therapies for Dry Eye Disease
Dry Eye Syndromes · Meibomian Gland Dysfunction
Primary: Change From Baseline in Non-invasive Tear Break Up Time to the Final Follow-up 3 Months After Final Treatment Session — -2.61; -0.85 seconds
N/A N=21 The Effects of Contact Lenses With UV/HEV-Filter on Visual Function
Visual Acuity
Primary: Visual Range at Phase 1 — 3.232; 3.049; 3.287; 3.167 log relative energy level
N/A N=20 Visual Performance of Senofilcon A With and Without a New UV/HEV-filter
Visual Performance
Primary: Photopic Contrast Sensitivity at 6 Cpd — 1.46; 1.91 Log Unit
Phase 4 N=64 Symfony vs Vivity in Dim Light
Cataract
Primary: Binocular Distance Corrected Intermediate Visual Acuity at 66 cm Under Mesopic Conditions. — 0.27; 0.32 logMAR
N/A N=154 Effect of Blue Light Filtration on Visual Performance
Cataract
Primary: Photostress Recovery Time — 5.66; 6.94 seconds
N/A N=126 Evaluation of Toric Soft Contact Lenses Containing a Chromophore to Block High-Energy Visible Light
Visual Acuity
Primary: CLUE Comfort Score — 63.50; 65.28 Units on a scale
N/A N=21 Toileting at Night in Older Adults: Light to Maximize Balance, Minimize Insomnia
Falls · Balance · Insomnia
Primary: Change in Balance — 6.66; 5.34; 5.62; 5.78 %CV
N/A N=20 Wearable Dark-adaptometer in Normal Adult Healthy Volunteers
Photoreceptor Sensitivity Thresholds
Primary: Time to Rod-cone Break (RCB) — 11.34; 9.98 Minutes
N/A N=60 The Effects of Contact Lenses With Experimental Dye on Visual Function
Ametropia
Primary: Two-Point Light Spread Function — 5.36; 6.71; 6.47; 7.48 mm
Phase 2 N=7 PF-06372865 in Subjects With Photosensitive Epilepsy
Reflex Epilepsy, Photosensitive
Primary: The Standardized Photosensitivity Range (SPR) in the Subject's Most Sensitive Eye Condition — 0.57; 1.38; 1.58; 6.80 Units on a scale
N/A N=500 RxSight Light Adjustable Lens and Light Delivery Device New Enrollment Study
Aphakia · Cataract
Primary: Absolute Manifest Refraction Spherical Equivalent (MRSE) Compared Between the Two Study Groups, LAL and Control — 0.210; 0.345 Diopters
N/A N=27 Light Therapy Treatment in Parkinson's Disease Patients With Daytime Somnolence
Parkinson's Disease · Sleep Disorder; Excessive Somnolence
Primary: Change in the Epworth Sleepiness Scale (ESS) Scores Comparing the Bright Light Exposure With Dim-red Light Exposure. — 4.46; 1.77 score — p=0.0211