Phase 2 N=22 Phase 1/2a Study on Allogeneic Osteoblastic Cells Implantation in Delayed-Union Fractures
Long Bone Delayed-Union Fracture
Primary: Percentage of Responders at 6 Months (Efficacy of ALLOB) — 100 percent of patients
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=13 Fracture (FX) Improvement With Teriparatide: FiX-IT Study
Osteoporosis · Atypical Femoral Fracture
Primary: Radiologic Evidence of Bone Healing — 12.6; 11.2; 15.4; 13.2 units on a scale
N/A N=53 Immediate Weight Bearing Versus Protected Weight Bearing in Supracondylar Distal Femur Fractures
Closed Supracondylar Fracture of Femur
Primary: Time to Distal Femur Fracture Healing by Radiographic Evidence — 1.75; 2.15 months
N/A N=60 Fixation of Unstable Distal Radius Fractures
Distal Radius Fractures
Primary: Average Difference Between Michigan Hand Outcomes Questionnaire Scores — 85.2; 91.8 units on a scale
Phase 3 N=120 Non-bridging Fixator Versus Percutaneous Pinning for Distal Radius Fractures
Radius Fractures
Primary: The Grip Strength — 98.3; 62.6 Percentage of opposite side — p=<0.05
N/A N=23 Humeral Shaft Pseudoarthrosis Treated With Bone Autograft Versus Platelet Rich Plasma
Pseudoarthrosis
Primary: Stans Scale — 2.7; 3.0 units on a scale
N/A N=30 Management of Traumatic Bone Defects in Tibial Plateau Fractures With Antibiotic-Impregnated Biodegradable Calcium Sulfate Beads: A Prospective Clinical Trial
Tibial Fractures · Intra-Articular Fractures · Fracture Fixation, Internal
Primary: Resorption of Study Device — 4 Participants
N/A N=33 Use of a Reinforced Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures
Tibial Fractures
Primary: Duration of Time the Patient Was in the OR as a Measure of Effectiveness of the Treatment — 107.0 Minutes
Phase 4 N=277 Study Evaluating InductOs in Diaphyseal Tibia Fractures
Tibial Fractures
Primary: Number of Patients With Healed Fractures — 83; 66; 8; 13 patients — p=0.0541
N/A N=20 Reduction and Fixation of Metatarsal Neck Fracture by Metaizeau's Technique
Displaced Metatarsal Neck Fracture
Primary: Time of Union — 5.8 weeks
Phase 3 N=122 Effect of Teriparatide on Hip Fracture Healing
Femur Neck Fracture
Primary: Percentage of Participants With No Revision Surgery at 12 Months After Internal Fixation of a Low-Trauma Femoral Neck Fracture — 87; 86 percentage of participants
N/A N=36 chronOS Inject in Proximal Tibial Fractures
Closed Proximal Tibial Fracture Schatzker I - VI · Closed Proximal Tibial Fracture AO-OTA 41 · Closed Proximal Tibial Fracture AO-OTA 42
Primary: Fracture Union — 27; 2 participants
N/A N=113 The Effect of Hypovitaminosis D and Vitamin D Supplementation on Fracture Nonunion Rates
Hypovitaminosis D
Primary: Fracture Union — 40; 39; 10 Participants
N/A N=20 Orthopaedic Treatment Proximal Humeral Fractures
Proximal Humeral Fracture
Primary: Constant Scale Evaluation at 3 Months and 12 Months From the Date of Trauma — 40.1; 51.8 units on a scale — p=<0.01
Phase 3 N=39 Second Study of the Effect of Teriparatide on Hip Fracture Healing
Femur Neck Fracture
Primary: Percentage of Participants With No Revision Surgery at 12 Months After Internal Fixation of a Low-Trauma Femoral Neck Fracture — 74; 93 Percentage of participants
Phase 2 N=402 Study of Romosozumab (AMG 785) in Tibial Diaphyseal Fractures Status Post Intramedullary Nailing
Fracture Healing
Primary: Time to Radiographic Healing — 16.4; 18.6; 18.3; 18.2 weeks — p=0.3598
N/A N=99 A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Proximal Tibial Fractures
Tibial Fractures
Primary: Participants' Quality of Life at 3 Months — 0.60; 0.59 score on a scale
N/A N=46 Effect of Healing Time on New Bone Formation Following Tooth Extraction and Ridge Preservation With Demineralized Freeze-Dried Bone Allograft
Bone Augmentation
Primary: Percent New Vital Bone Formation — 32.63; 47.41 percentage of vital bone
N/A N=156 A Multicenter Randomized Trial Comparing IM Nails and Plate Fixation in Distal Femur Fractures
Femoral Fractures
Primary: EQ-5D — 69.23; 72.81; 74.24; 73.04 units on a scale
N/A N=63 Comparison of Early and Late Therapy for Adults With Non-Operatively Treated Proximal Humerus Fractures
Proximal Humeral Fractures
Primary: Shoulder Flexion — 150; 146 Degrees
N/A N=118 The Outcomes of Proximal Humerus Fractures in Children
Humeral Fractures
Primary: Number of Participants With Indicated Status as Assessed by Mail Questionnaire Upper Extremities Functional Index (UEFI) — 4; 4; 24 Participants
N/A N=103 A Post-Market Clinical Evaluation of the Treatment of Tibia Fractures With the T2 Alpha Tibia Nailing System
Tibial Fractures
Primary: SF-36 PCS (36-Item Short Form Health Survey Physical Component Summary) — 49.21 score on a scale
Phase 2 N=35 PTH(1-34) and Pelvic Fracture Healing - a Randomized Controlled Trial
Osteoporotic Fractures
Primary: Number of Participants With Evidence of Cortical Bridging for Fracture Healing — 9; 8 Participants
N/A N=30 Wrist Fracture Evaluation With a Desktop Orthopedic Tomosynthesis System
Fracture
Primary: Sensitivity — 96.7 percent of scans with a fracture
N/A N=142 BBOT: Bacterial Burden in Ortho Trauma Procedures
Orthopaedic Trauma Infections
Primary: Number of Participants With Tissue Samples Identified With Bacterial DNA According to Highly Sensitive Bacterial Assays — 10; 24; 20 Participants
Phase 2 N=11 Proof-of-concept Study With NVDX3 for Treatment of Distal Radius Fractures.
Distal Radius Fractures
Primary: Safety: Serious Treatment-emergent Adverse Events (TEAEs) and NVDX3-related TEAEs — 1; 1 Participants
N/A N=216 Randomized Trial of Casting Techniques for Displaced Forearm Fractures
Displaced Forearm Fractures
Primary: Loss of Radius Fracture Reduction — 35; 35; 66; 66 participants — p=1.00
N/A N=16 Comparative Efficacy of the Masquelet Versus Titanium Mesh Cage Techniques for the Treatment of Large Long Bone Defects
Segmental Long Bone Defects
Primary: Number of Participants With Defect Healing - Plain Radiography — 9; 7 Participants
N/A N=62 Cast Immobilization for Non-Displaced Scaphoid Fractures
Non-displaced Scaphoid Fractures
Primary: Extent of Union — 70; 85 percentage of union
N/A N=225 Incidence and Risk Factors for Surgical Site Infection After Intramedullary Nailing of Femoral and Tibial Fractures
Fracture Fixation, Intramedullary · Surgical Wound Infection
Primary: Incidence of Surgical Site Infection (SSI) Relating to Intramedullary Nailing for Fixation of Diaphyseal Femoral and Tibial Fractures — 26; 195 Participants