N/A N=212 Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Intrauterine Resuscitation
Primary: Umbilical Artery Malondialdehyde — 9.8; 10.2 umol/L
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=114 Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings
Electronic Fetal Monitoring · Fetal Hypoxia · Fetal-Placental Circulation
Primary: Mean Umbilical Artery Lactate at Delivery — 3.5; 3.4 mmol/L — p=0.69
N/A N=844 The Comparative Effectiveness of Liberal Versus Restricted Maternal Administration of Oxygen During Labor
Maternal Oxygen Use in Labor
Primary: Number of Participants Who Delivered by Cesarean — 83; 75 Participants
N/A N=40 Pre-Oxygenation Techniques in Pregnancy
Preoxygenation
Primary: End Tidal Oxygen Concentration (ETO2) Following Tidal Volume Breathing Using Either Face Mask or OptiFlow — 91.0; 87.4 Percentage units of end-tidal oxygen
N/A N=70 Supplemental Oxygen Study
Cesarean Section · Supplemental Oxygen · Umbilical Cord Gases
Primary: Umbilical Cord pH Levels — 7.29; 7.28 pH
N/A N=57 Does Maternal Fever During Labor Analgesia Has Any Relationship With Maternal Ventilation?
Pregnancy
Primary: Changes in Maternal Ventilation During Labor Analgesia — 15.3; 12.6; 13.8 L/min
Phase 4 N=1,003 Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation
Dystocia
Primary: Number of Participants Delivered by Cesarean — 73; 72 Participants
N/A N=91 Preoxygenation Using THRIVE Versus Facemask in Parturients
Preoxygenation
Primary: Preoxygenation Duration — 3.6; NA; NA minutes
N/A N=347 Use of an Occlusal Support Device During the Second Stage of Labor
Pregnancy
Primary: Stage 2 Duration of Labor — 120.2; 107 minutes
Phase 3 N=51 Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.
Postpartum Hemorrhage
Primary: Total Estimated Blood Loss — 512; 634 ml
Phase 4 N=170 Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor
Labor Long
Primary: Time to Delivery — 1041.8; 971.1 minutes
N/A N=65 Continuous Non-Invasive Measurement of Hemoglobin During Parturition
Hemorrhage · Cesarean Section
Primary: Pearson Correlation Coefficient for Hemoglobin Measurements — 0.6 Correlation Coeficient
Phase 4 N=160 Multimodal Uterotonics at the Time of Cesarean Section in Laboring Patients
Uterine Atony With Hemorrhage
Primary: Number of Participants With Need for Additional Uterotonics (Methylergonovine, Carboprost, Misoprostol) — 80; 80 Participants
N/A N=31 Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation
Respiratory Distress Syndrome in Premature Infants · Very Low Birth Weight Baby
Primary: Maximum Factional Inspired Oxygen Percent (FiO2) — 48; 39 percentage of Inspired Oxygen — p=0.0012
N/A N=252 Induction of Labor With Oxytocin: When Should Oxytocin be Held?
Labor Induction · Cesarean Delivery
Primary: Cesarean Delivery — 32; 24 Cesarean deliveries
Phase 4 N=20 A Pilot Study: High Versus Low Oxytocin Dosing for Induction of Labor in Pregnant Patients With Obesity
Pregnant Patients With Obesity
Primary: Number of Participants Delivered by Cesarean — 3; 3 Participants
Phase 4 N=60 Oxytocin And Uterotonic Agent Use For Cesarean Delivery
Uterine Atony · Hypotension
Primary: 1. Amount of Oxytocin to Obtain Satisfactory Uterine Tone. — 8.4; 4.0 IU
N/A N=276 Pulse Pressure and Post-epidural Fetal Heart Rate Changes
Fetus or Neonate Affected by Maternal Epidural Anesthesia During Labor and Delivery
Primary: Incidence of New-onset Category II or III Fetal Heart Rate Tracings — 72; 52 Participants
N/A N=80 The Maternal and Perinatal Outcomes Associated With the Use of Non-pharmacological in Labor
Pain
Primary: Number of Participants Who Requested Analgesia During the Active Phase of Childbirth — 37; 35 Participants
N/A N=99 Determination of the Predictors of Nocturnal Desaturation in Postpartum Women
Sleep Disordered Breathing · Nocturnal Oxygen Desaturation · Upper Airway Edema
Primary: SpO2 < 90% — 0.4; 0.0; 0.1; 0.0 minutes
Phase 4 N=140 Oxytocin Dosage to Decrease Induction Duration
Obesity · Labor, Induced · Oxytocin
Primary: Length of Time to Delivery — 796; 694; 715; 762 minutes
Phase 4 N=176 Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia
Preeclampsia · Labor, Premature
Primary: Cesarean Delivery Rate — 29; 22 Participants
Phase 4 N=1,798 Oxytocin Regimen to Prevent Atony and Postpartum Hemorrhage During Vaginal Delivery: 3-arm RCT
Uterine Atony · Postpartum Hemorrhage
Primary: Number of Subjects Reporting Uterine Atony or Postpartum Hemorrhage Requiring Medical (Medication or Blood Transfusion), Surgical or Other Interventional Treatment — 45…
N/A N=35 Refinement of the OBMedical LaborView System
Fetal Monitoring
Primary: Fetal Heart Rate With the Laborview System Versus the CTG Monitor - Pilot Comparison Study — 5.282 beats per minute — p=<.1
N/A N=108 Obstructive Sleep Apnea in Pregnancy
Sleep Apnea, Obstructive · Pregnancy · Obesity, Morbid
Primary: Number of Participants With a Negative Obstructive Sleep Apnea (OSA) Home Sleep Test Result — 61 Participants
N/A N=27 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)
Transposition of the Great Vessels · Hypoplastic Left Heart Syndrome · Oxygen Consumption Based Assessment of Hemodynamics
Primary: Oxygen Consumption — 72; 102 mL oxygen/min/m^2
N/A N=29 Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period
Hypoplastic Left Heart Syndrome · Total Anomalous Pulmonary Venous Return · Truncus Arteriosus
Primary: Systemic Oxidative Stress Based on Thiobarbituric Acid Reactive Substances (TBARS) — 1.21; 1.93; 1.09; 1.77 Fold Change from Baseline — p=<0.01
N/A N=80 Non-pharmacological Resources in Assisting Labor
Labour Pain
Primary: Pain Relief — 79.5; 73.8; 71.0; 51.7 millimeters
Phase 4 N=120 Multimodal Pain Management for Cesarean Delivery
Pain
Primary: Total Opioid Intake in Morphine Milligram Equivalents in the First 48 Hours After Cesarean Delivery (CD) — 42; 49.5 morphine milligram equivalents
Phase 3 N=180 Study of the Effectiveness of Cervical Ripening Balloon With and Without Oxytocin
Cervical Ripening · Induction of Labor · Multiparity
Primary: Time From Cervical Ripening to Delivery — 16.88; 13.13 hours