N/A N=106,629 Effects of Code Sepsis Implementation on Emergency Department (ED) Sepsis Care
Sepsis
Primary: Door-to-antibiotic Time — 160; 146; 139; 140 minutes — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=121 Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis
Sepsis
Primary: Antibiotic Treatment for More Than 72 Hours — 33; 55 participants — p=0.002
N/A N=400 Timing of Antibiotic Prophylaxis for Cesarean Deliveries
Infection
Primary: Endometritis and Wound Infection — 6; 4 patients infected
N/A N=28 Sepsis-Associated Purpura Fulminans International Registry - Europe
Sepsis
Primary: Mortality — 11 Participants
N/A N=44 Reduction of Endometritis After Cesarean Section With the Routine Use of Methergine
Endometritis
Primary: Endometritis Incidence — 0; 0 participants
N/A N=22 Piperacillin PK Analysis in Severe Sepsis Patients
Sepsis · Severe Sepsis
Primary: 100% f T>MIC: Free Piperacillin Concentration Maintained Above the MIC Throughout the Dosing Interval. — 4 participants
N/A N=995 Neonatal Outcome by Reason for Delivery
Preterm Delivery
Primary: Composite Perinatal Morbidity — 277; 203; 221; 45 participants
Phase 3 N=58,747 Azithromycin-Prevention in Labor Use Study (A-PLUS)
Maternal Death · Maternal Infections Affecting Fetus or Newborn · Neonatal SEPSIS
Primary: Maternal Death or Sepsis Within 6 Weeks (42 Days) Post-delivery in Intervention vs. Placebo Group. — 227; 344 Participants — p=<0.001
N/A N=185 Algorithm for Predicting the Unfavorable Course of Sepsis in Children
Sepsis
Primary: Blood Leukocyte Subpopulations: the Absolute Numbers of Leukocytes of Specific Phenotypes — 16.0; 11.2; 11.9; 4.9 10^9 cells/l — p=<0.05
N/A N=18,693 Paediatric Rapid Sepsis Trigger (PRST) Tool
Sepsis · Infection
Primary: Time to Administration of an Appropriate Antimicrobial — 115; 123; 239; 261 minutes
N/A N=65 Utility of Placental/Umbilical Cord Blood in Early Onset Neonatal Sepsis in Very Low Birth Weight Infants
Preterm Infant · Early-Onset Neonatal Sepsis · Umbilical Cord
Primary: White Blood Cell Count (WBC) (1) — 8257 ratio of cells/mm3
N/A N=57 Does Maternal Fever During Labor Analgesia Has Any Relationship With Maternal Ventilation?
Pregnancy
Primary: Changes in Maternal Ventilation During Labor Analgesia — 15.3; 12.6; 13.8 L/min
N/A N=142 Preemptive Resuscitation for Eradication of Septic Shock
Sepsis · Severe Sepsis
Primary: Number of Participants With Worsening Organ System Dysfunction Defined by SOFA Score Increase ≥ 1 — 34; 20 Participants — p=0.064
N/A N=14,490 Smart Discharges for Mom & Baby
Maternal Sepsis · Neonatal Sepsis
Primary: Post-discharge Readmission or Mortality — 231; 349 Participants
Phase 2 N=120 Vitamin C & Thiamine to Treat Sepsis and Septic Shock
Sepsis · Septic Shock
Primary: Mortality Rates — 12; 7 Participants — p=0.344
Phase 4 N=756 Antibiotic Prophlaxis for High-risk Laboring Women in Low Income Countries
Postpartum Sepsis · Postpartum Endometritis · Postpartum Fever
Primary: Number of Participants Who Experienced Composite Peripartum Infection or Death — 15; 17; 24 Participants
Phase 4 N=160 Multimodal Uterotonics at the Time of Cesarean Section in Laboring Patients
Uterine Atony With Hemorrhage
Primary: Number of Participants With Need for Additional Uterotonics (Methylergonovine, Carboprost, Misoprostol) — 80; 80 Participants
Phase 4 N=202 Clindamycin Once a Day in Septic Abortion
Septic Abortion
Primary: Cure (Clinical Improvement Defined as Reduce of Pain, Bleeding and no Fever for 48h) — 94.06; 86.14 percentage of cure — p=0.06
N/A N=144 Integrated Predictive Monitoring for Sepsis and Necrotizing Enterocolitis
Sepsis · Necrotising Enterocolitis Neonatal
Primary: Number of Participants With Sepsis or Necrotizing Enterocolitis — 20; 124 Participants
N/A N=226 Utility of Presepsin in Distinguishing Between Sepsis and SIRS
SIRS · Sepsis
Primary: Area Under the Receiver Operating Characteristic Curve (ROC-AUC) of the Plasma Presepsin Concentration for Discriminating Between SIRS and Sepsis — 0.7218; 0.6901…
Phase 3 N=9 Late-onset Sepsis in Term and Pre-term Neonates and Infants up to 3 Months of Age
Neonatal Sepsis
Primary: Number of Patients With Adverse Events (AEs) — 3; 3; 0; 0 Participants
N/A N=21 Inflammatory Cytokine Quantification in Infants
Sepsis · Congenital Diaphragmatic Hernia · Neonatal Cardiopulmonary Failure
Primary: TNF-alpha, Baseline — 8.88 pg/mL
Phase 3 N=30 Cholecalciferol Supplementation for Sepsis in the ICU
Hypovitaminosis D
Primary: Change in Vitamin D Status 5 Days Following Supplementation With Cholecalciferol — 19; 15; 17; 19 ng/mL
N/A N=7,407 Effects of External Inspection on Sepsis Detection and Treatment
Sepsis
Primary: Number of Sepsis Patients With 30 Days Mortality — 377; 424; 3217; 3389 Participants — p=0.24
Phase 2 N=46 Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)
Chorioamnionitis · Brain Injury
Primary: NAC Terminal Elimination Half-life — 1.2; 7.5; 5.1 hours
Phase 2 N=140 Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis.
Sepsis, Severe · Septic Shock
Primary: Time to Vasopressor Independence (Hours) — 27; 53 hours — p=<0.001
N/A N=15 PK Analysis of Piperacillin in Septic Shock Patients
Septic Shock
Primary: 100% f T>MIC: Free Piperacillin Concentration Maintained Above the MIC Throughout the Dosing Interval. — 10 participants
N/A N=212 Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Intrauterine Resuscitation
Primary: Umbilical Artery Malondialdehyde — 9.8; 10.2 umol/L
Phase 2 N=488 Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
Acute Respiratory Distress Syndrome · Critical Illness · Respiratory Failure
Primary: Days Alive and Free of Organ Support to Day 28 — 20.2; 20.5; 19.7; 18.4 days — p=0.65
N/A N=99,659 A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth
Post-Partum Haemorrhage
Primary: The Primary Outcome is a Composite of the Following Three Clinical Outcomes: 1) Severe PPH Defined as Blood Loss ≥1000 ml or; 2) Postpartum Laparotomy for Bleeding or…