N/A N=82 Trans-Nasal Maxillary Multi-Sinus Balloon Dilation Study
Sinusitis
Primary: Change in SNOT-20 Score — 2.3; 0.7 score on a scale — p=<0.0001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=40 Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis
Sinusitis
Primary: Number of Patients Recommended for Sinus Surgery After 3 Weeks of Antibiotic Therapy — 7; 8; 0; 6 Participants
Phase 4 N=166 Treatment of Acute Sinusitis
Acute Respiratory Infections · Acute Rhinosinusitis
Primary: SNOT-16 Score (Sino-Nasal Outcomes Test) at Day 3 — 1.12; 1.14 Units on a scale — p=0.83
Phase 2 N=43 Anti-Inflammatory Agent in Sinusitis
Nasal Polyps
Primary: TOTAL POLYP SCORE (TPS) — 4.67; 5.24 units on a scale — p=<0.05
Phase 4 N=53 Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis
Chronic Rhinosinusitis (Diagnosis) · Allergic Rhinosinusitis · Chronic Eosinophilic Rhinosinusitis
Primary: Change in Sino-Nasal Outcome Test Scores (SNOT-22) — 23.18; 17.7 score on a scale
Phase 4 N=179 Clinical Trial of the Treatment of Acute Sinusitis With Standard-dose Versus High-dose Amoxicillin/Clavulanate
Sinusitis
Primary: Subjective Improvement - Day 3 (Rating of "a Lot Better" or "no Symptoms") — 33; 31; 22; 33 Participants
Phase 3 N=25 Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
Chronic Rhinosinusitis
Primary: Change in Rhinosinusitis Disability Index (RSDI) Score — -8.000; -14.82 units on a scale — p=0.505
Phase 2 N=16 Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis
Sinusitis · Cystic Fibrosis
Primary: Computed Tomography Evidence of Less Sinus Disease — 5.875; 3 units on a scale — p=0.2
N/A N=151 Randomized Evaluation of Maxillary Antrostomy Versus Ostial Dilation Efficacy Through Long-Term Follow-Up
Chronic Sinusitis
Primary: Sinus Symptom Improvement — -1.59; -1.60; 0.88; 0.88 units on a scale — p=<0.001
N/A N=100 In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia
Chronic Sinusitis
Primary: Patency Rate — 38; 33 sinus sides — p=0.0391
Phase 3 N=386 Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis
Acute Rhinosinusitis
Primary: Major Symptom Score (MSS) Assessed by the Investigator — 2.38; 3.41 units on a scale
Phase 1 N=36 Safety and Performance of the SinuSys Dilation System for Dilation of the Maxillary Sinus Ostium
Sinusitis
Primary: Patency of Treated Area — 95 percentage of ostia treated
Phase 2 N=20 Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia
Chronic Sinusitis With Nasal Polyps and Eosinophilia
Primary: Ratio to Baseline in Peripheral Blood Eosinophil Counts After 6 Months of Treatment — 0.06 ratio to baseline — p=< 0.001
N/A N=123 Non-Interventional Open Label Prospective Comparative Observational Study Of Evaluation Of Compliance In The Empiric Treatment With Azithromycin SR Versus Amoxiclav 1000 Mg In Adult Patients With Of Acute Bacterial Maxillary Sinusitis
Maxillary Sinusitis
Primary: Percentage of Participants With Response of Very Convenient or Somewhat Convenient — 100.0; 72.9 Percentage of Participants — p=<0.0001
Phase 2 N=71 Balloon REmodeling Antrostomy THErapy Study
Sinusitis
Primary: Incidences of Device-related or Procedure-related Complications — 1 participants
Phase 2 N=24 Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis
Chronic Rhinosinusitis (Diagnosis) · Nasal Polyps · Eosinophilia
Primary: Change in Nasal Polyp Score — .9; .3 score on a scale
N/A N=37 The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery
Chronic Sinusitis · Nasal Polyposis
Primary: Change in Lund-Kennedy Endoscopic Scores — -8.0; -1.5; -6.9 score on a scale
N/A N=25 Study for the Management of Pediatric Chronic Rhinosinusitis With or Without Balloon Sinuplasty
Rhinitis + Sinusitis, Pediatric Chronic Rhinosinusitis
Primary: Quality of Life (QoL) Outcomes Between Adenoidectomy + Maxillary Sinus Irrigation With or Without the Use of Balloon Dilation or Maxillary Sinus Ostia. — 2.48; 2.5…
Phase 3 N=374 BAY12-8039: 5 Days for Sinusitis vs Placebo
Sinusitis
Primary: Percentage of Subjects With Clinical Cure (Modified Intent-to-Treat (MITT)) — 78.1; 66.7; 19.2; 33.3 Percentage of subjects — p=0.189
Phase 2 N=19 Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis
Rhinosinusitis
Primary: Change of Inflammation of the Nasal Mucosa and Paranasal Sinus — 0; -0.8 score on a scale
N/A N=187 Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery
Chronic Rhinosinusitis · Endoscopic Sinus Surgery
Primary: Total Subjective Symptoms Visual Analog Scores (VAS) — 20.4; 20.7; 9.7; 8.9 score on a scale
Phase 3 N=27 Study to Assess the Efficacy and Safety of Potassium Clavulanate/Amoxicillin in Children With Acute Bacterial Rhinosinusitis
Sinusitis, Acute
Primary: Number of Participants With a Clinical Outcome of "Cure" at Test of Cure (TOC: Day 15) — 23; 3; 0 Participants
Phase 2 N=22 The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis
Rhinosinusitis
Primary: Change in Sino-nasal Outcome Test-22 Score Between Baseline and 6 Weeks, Then 6 Weeks to 12 Weeks. — 59.3; 52.9; 45.4; 51.8 units on a scale
Phase 3 N=196 Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults
Chronic Sinusitis · Chronic Rhinosinusitis (Diagnosis)
Primary: Change From Baseline (CFBL) in the 7-day Average Composite Score of 3 Cardinal Symptoms (3CS) in Participants Without Nasal Polyps. — -2.13; -2.06 score on a scale
Phase 3 N=944 Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis
Rhinosinusitis
Primary: Mean Change From Baseline in the Daily Major Symptom Score (MSS) Over the Entire Treatment Period, Full Analysis Set — -4.8213; -4.7394; -4.7758; -5.0180 Score on a scale
Phase 4 N=39 Allergic Rhinitis Changes the Sinus Microbiome
Seasonal Allergic Rhinitis
Primary: Total Nasal Symptom Score (TNSS) — 67.1; 78.0 score on a scale — p=0.391
Phase 4 N=77 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis
Chronic Rhinosinusitis
Primary: Mean Reduction in SNOT-20 Scores — 1.8; 5.5 units on a scale — p=0.23
Phase 4 N=68 The Use of Antibiotic Sinonasal Rinse After Sinus Surgery
Chronic Rhinosinusitis
Primary: Quality of Life in Chronic Rhinosinusitis Patients — 23; 21 Units on a scale
Phase 4 N=118 Pain Control Following Sinus Surgery
Sinusitis · Opioid Use · Opioid Abuse
Primary: Pain Severity — 12.4; 8.5 units on a scale
N/A N=24 Oral Steroids in Chronic Rhinosinusitis Without Nasal Polyps
Sinusitis
Primary: Sinonasal Outcome Test (SNOT 20) — 50.33; 53.14; 37 Score out of total 100