N/A N=47 Females, Aging, Metabolism, and Exercise
Obesity
Primary: Change in Physical Activity Energy Expenditure (PAEE) — 74.5; -10.2; 61.0 kcal/day
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=13 Energy Metabolism in Thyroidectomized Patients
Thyroid Goiter · Hypothyroidism · Thyroid Cancer
Primary: Short Term Change in Weight — 1.7; -0.76 Kilogram
N/A N=10 Circadian Brown Adipose Tissue Metabolism
Healthy
Primary: Change in Maximum Standardized Update Value (SUVmax) in Brown Adipose Tissue FDG Uptake in the Neck or Upper Chest on Evening and Imaging Compared to Morning Imaging
N/A N=20 Hepatic Mitochondrial Function in Youth
Hepatic Steatosis · Bariatric Surgery Candidate · Adolescent Obesity
Primary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat
Phase 3 N=31 Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)
Healthy Volunteers
Primary: Energy Expenditure — 1.37; 1.40; 1.28; 1.27 kcal/min — p=0.0001
N/A N=90 FGF-21 Levels and RMR in Children and Adolescents With Hashimoto's Thyroiditis (THYROMETABOL)
Hashimoto Disease
Primary: Fibroblast Growth Factor 21 (FGF-21) — 182.71; 217.36; 198.43 pg/mL
N/A N=32 Metabolomics of Insomnia-Related Hyperarousal
Primary Insomnia
Primary: Number of Metabolites Elevated Relative to the Other Group. — 13; 9 Number of metabolites elevated
Phase 3 N=601 Metabolism Informed Smoking Treatment: The MIST RCT
Smoking
Primary: Biochemically-validated Past 7-day Point Prevalence Tobacco Abstinence — 54; 49 Participants — p=0.461
N/A N=39 Effect of Caloric Restriction on Fat Oxidation in Obese Men and Women (Magellan II)
Obesity · Overweight · Metabolic Diseases
Primary: Change From Baseline Amount of Fat Oxidation at 14 Days — 0.91; 0.94 Fold change of RQ ratio
N/A N=26 Effects of 12 Weeks of Omega 3 Supplementation on Resting Metabolic Rate
Whole Body Energy Metabolism
Primary: Change in Resting Metabolic Rate From Baseline — -0.19; -0.19; 0.67; 1.11 percent change
N/A N=46 Activity, Adiposity, and Appetite in Adolescents 2
Obesity · Metabolic Disease · Insulin Sensitivity
Primary: Appetite- Subjective — 9239.4; 7879.6; 6130.5; 8970.0 score on a scale*min
N/A N=121 Developmental Regulation of Proteins Responsible for Transforming Drugs in the Body
Healthy
Primary: Change in CYP2D6 Drug Metabolism Phenotype With Age — -1.974; -2.083; -2.162; -2.073 unitless ratio — p=0.035
N/A N=54 Food Intake Response to Short-Term Modifications of Metabolism in Humans
Healthy Volunteers
Primary: 24-hour Energy Expenditure (kcal) — 2256; 2166; 2563; 2487 kcal
N/A N=38 Mechanisms of Obesity and Its Metabolic Complications in Youth
Obesity, Childhood
Primary: Rate of Appearance of Acetate — 7.40; 7.69; 9.29; 14.7 umol/kg/min
N/A N=12 Metabolic Syndrome and Fall Risk
Metabolic Syndrome · Autonomic Neuropathy
Primary: Four Square Step Test (FSST) — 11.04; 14.29 seconds
Phase 2 N=24 Fecal Microbiota Transplant for Improvement of Metabolism
Obesity
Primary: Percent Change From Baseline in Insulin Resistance Based on Insulin-Stimulated Glucose Uptake (M) During Hyperinsulinemic Euglycemic Clamp — -3; 5 percent change — p=0.16
N/A N=8,584 Low Indexes of Metabolism - Information to Teams (LIMIT)
Weight Loss · Thinness · Malnutrition
Primary: Death From Any Cause — 285; 245 Participants
N/A N=15 Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
Weight Loss · Starvation
Primary: Change in Resting Metabolic Rate — -63.4; -77.6; -47.4 kcal change
Phase 2 N=47 Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Healthy Volunteers
Primary: Resting Energy Expenditure at Low Temperature — 1.277; 1.134; 1.300; 1.271 kcal/min
N/A N=98 Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation
Mild Cognitive Impairment · Metabolic Syndrome
Primary: MoCA (Montreal Cognitive Assessment) — 28.38; 20.22 score on a scale — p=<0.0001
N/A N=24 Metabolic Effects of Olanzapine in Healthy Males
Healthy
Primary: Change From Baseline in Weight — 0.2; 1.7 Kg
N/A N=24 Growth Hormone as a Determinant of Weight Regulation
Obesity
Primary: 24 Hour Average Plasma Growth Hormone Concentration — 0.4; 1.2; 4.1 ng/mL
Phase 2 N=20 EPI-743 for Metabolism or Mitochondrial Disorders
Mitochondrial Disease · Neurology · Myopathy
Primary: Newcastle Paediatric Mitochondrial Disease Scale (NPMDS) Part I-III, Baseline — 23.9; 20.4 Units on a scale
N/A N=15 High-fat Meal Challenge in Pediatrics
Pediatric Obesity · Insulin Resistance
Primary: Palatability of the High Fat Agent. — 13 Participants — p=0.15
N/A N=26 Fatty Acid Oxidation Disorders & Body Weight Regulation Grant
Trifunctional Protein Deficiency
Primary: An Outcome of This Study is the Difference in Percent Body Fat (%BF) Between Subjects With a Long-chain Fatty Acid Oxidation Disorder and Normal Controls. — 31.8; 27.2…
Phase 1 N=6 Metabolism and Pharmacokinetics of [14C]-BI 409306 After Administration as Oral Solution in Healthy Male Volunteers
Healthy
Primary: Mass Balance Recovery of Total Radioactivity in Urine and Faeces: Amount Excreted Within the Time Interval From 0 to the Time of the Last Quantifiable Data Point as a…
N/A N=37 Forearm Immobilization, Metabolic Health, and Muscle Loss
Healthy
Primary: Percent Change in Forearm Glucose Uptake — -73; 127; -95 Percent change in clamp FGU with immob
N/A N=33 Training Effects on Skeletal Muscle Fatty Acid Metabolism
Healthy Volunteers
Primary: Insulin Sensitivity as Measured by Hyperinsulinemic Euglycemic Clamp at a Single Time Point (6 Hrs) After Intralipid or Glycerol Infusion — 8; 12; 6; 11 M value — p=<0.05
N/A N=21 Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism
Healthy · Healthy Volunteers
Primary: Ad Libitum Energy Intake — 2752; 2063 kcal per day
N/A N=27 Metabolic Study of Sleep Apnea in Men and Women
Obstructive Sleep Apnea (OSA)
Primary: Polysomnography - Apnea-hypopnea Index (AHI) — 11.4; 0.7; 6; 1.1 units on a scale