N/A
Completed N=20
Hepatic Mitochondrial Function in Youth
fatty liver · Bariatric Surgery Candidate · Adolescent Obesity · Obesity
Source: ClinicalTrials.gov NCT03587727 ↗
Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcomePrimary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat
Summary
Assess the impact of bariatric surgery on hepatic energy metabolism and glucose and insulin dynamics in obese youth
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Percentage of Liver Fat Per MRI |
-13.93 | — |
| PRIMARY Change in %Direct TG-Glycerol Appearance |
0.33 | — |
| SECONDARY Change in Insulin Sensitivity |
0.000552758 | — |
| SECONDARY Change in Peak Glucose |
11.5 | — |
| SECONDARY Change in Minimum Glucose |
-7 | — |
| SECONDARY Change in Peak Insulin |
28.333 | — |
| SECONDARY Change in Minimum Insulin |
-7.333 | — |
| SECONDARY Change in Peak C-peptide |
1.7 | — |
| SECONDARY Change in Peak GLP-1 |
-7.1117 | — |
| SECONDARY Change in Fasting Glucagon |
-41.333 | — |
| SECONDARY Change in Liver Stiffness Per MRI |
-0.234 | — |
| SECONDARY Mitochondrial Function in the Liver Assessed by Oroboros |
0.34; 0.50 | — |
| SECONDARY Hepatic Steatosis Score Via Tissue Biopsy |
3; 1; 3; 4; 3; 1 | — |
Eligibility Criteria
Inclusion Criteria
- Obese youth ages 13-20 years, scheduled for bariatric surgery at Children's Hospital Colorado
- BMI 35-55 m2/kg
- Maximal body circumference 6.4%
- Anemia, defined as Hemoglobin < 10 mg/dL
- Diagnosed major psychiatric or developmental disorder limiting informed consent
- Implanted metal devices that are not compatible with MRI
Data sourced from ClinicalTrials.gov (NCT03587727). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.