N/A N=20

Hepatic Mitochondrial Function in Youth

Hepatic Steatosis · Bariatric Surgery Candidate · Adolescent Obesity · Obesity

Bottom Line

View on ClinicalTrials.gov: NCT03587727 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2025

Primary outcome: Primary: Change in Percentage of Liver Fat Per MRI — -13.93 percentage of liver fat

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: —
Age: Pediatric, Adult · 13+ yrs
Sex: All
Sponsor: University of Colorado, Denver
Primary completion: Jun 2023

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Percentage of Liver Fat Per MRI	-13.93	—
PRIMARY Change in %Direct TG-Glycerol Appearance	0.33	—
SECONDARY Change in Insulin Sensitivity	0.000552758	—
SECONDARY Change in Peak Glucose	11.5	—
SECONDARY Change in Minimum Glucose	-7	—
SECONDARY Change in Peak Insulin	28.333	—
SECONDARY Change in Minimum Insulin	-7.333	—
SECONDARY Change in Peak C-peptide	1.7	—
SECONDARY Change in Peak GLP-1	-7.1117	—
SECONDARY Change in Fasting Glucagon	-41.333	—
SECONDARY Change in Liver Stiffness Per MRI	-0.234	—
SECONDARY Mitochondrial Function in the Liver Assessed by Oroboros	0.34; 0.50	—
SECONDARY Hepatic Steatosis Score Via Tissue Biopsy	3; 1; 3; 4; 3; 1	—

Summary

Assess the impact of bariatric surgery on hepatic energy metabolism and glucose and insulin dynamics in obese youth

Eligibility Criteria

Inclusion Criteria

Obese youth ages 13-20 years, scheduled for bariatric surgery at Children's Hospital Colorado
BMI 35-55 m2/kg
Maximal body circumference 6.4%
Anemia, defined as Hemoglobin < 10 mg/dL
Diagnosed major psychiatric or developmental disorder limiting informed consent
Implanted metal devices that are not compatible with MRI

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT03587727). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.