Phase 2 N=64 Therapy for Children With Advanced Stage Neuroblastoma
Neuroblastoma
Primary: Overall Response Rate [Complete Response + Very Good Partial Response + Partial Response (CR + VGPR + PR)] — 42 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=15 N2007-01: Ultratrace™ Iobenguane I 131 in Patients With Relapsed/Refractory High-Risk Neuroblastoma
Neuroblastoma
Primary: Maximum Tolerated Dose — 18.6 mCi/kg
Phase 2 N=50 N2001-02: I-MIBG With Intensive Chemotherapy and Autologous Stem Cell Rescue for High-Risk Neuroblastoma
Neuroblastoma
Primary: Response (Complete Response, Very Good Partial Response, and Partial Response) at 60-days Post Stem Cell Infusion — 4; 3 participants
Phase 1 N=150 Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma
Ganglioneuroblastoma · Stage 1 Neuroblastoma · Stage 2 Neuroblastoma
Primary: The Tolerability of BuMel Regimen — 9 participants
Phase 2 N=114 131I-MIBG Alone VS. 131I-MIBG With Vincristine and Irinotecan VS131I-MIBG With Vorinostat
Neuroblastoma
Primary: Objective Tumor Response After One Course of Therapy — 5; 5; 11 Participants
Phase 1 N=45 MIBG With Dinutuximab +/- Vorinostat
Neuroblastoma
Primary: MTD/RP2D Determination Cohort A — 0; 0; 0 Participants
Phase 1 N=32 High-Dose 131I-MIBG Therapy Combined With Vincristine and Five Days of Irinotecan for Resistant/Relapsed Neuroblastoma
Neuroblastoma
Primary: Number of Participants With Dose-limiting Toxicity as a Measure of Tolerability — 0; 0 participants with DLT
Phase 3 N=105 Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma
High Risk Neuroblastoma
Primary: Percentage of Patients Who Experienced a Significant (CTC Grade 3-5) Nonhematologic Toxicity of Interest (Pain, Hypotension, Allergic Reactions, Capillary Leak Syndrome…
Phase 1 N=99 Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With Isotretinoin
Ganglioneuroblastoma · Localized Resectable Neuroblastoma · Localized Unresectable Neuroblastoma
Primary: Percentage of MIBG Avid Patients Treated With Meta-iodobenxylguanide (MIBG) Labeled With Iodine-131 — 86.8 Percentage of participants
Phase 2 N=59 Irinotecan and Temozolomide in Treating Young Patients With Recurrent Neuroblastoma
Neuroblastoma
Primary: Overall Response - Complete Response (CR), Very Good Partial Response (VGPR) and Partial Response (PR) — 5; 3 participants
Phase 2 N=34 Bevacizumab, Irinotecan and Temozolomide for Relapsed or Refractory Neuroblastoma
Neuroblastoma
Primary: Overall Responses — 3; 18; 12; 1 Participants
N/A N=16 Molecular Guided Therapy for Refractory or Recurrent Neuroblastoma
Neuroblastoma
Primary: Percentage of Participants That Are Able to Meet Feasibility Parameters. — 100 percentage of participants
Phase 2 N=36 A Phase I/II Study of [124I]mIBG PET/CT in Neuroblastoma
Metastatic Neuroblastoma
Primary: Comparison of the Number of Lesions Detected as Positive by [123I]mIBG Planar Scintigraphy Which Are Also Considered Positive With [124I]mIBG PET/CT. — 714; 405 Lesions…
Phase 2 N=13 Protracted Etoposide During Induction Therapy for High Risk Neuroblastoma
Neuroblastoma
Primary: Response Rate Associated With Two Cycles of Cisplatin With Protracted Oral Etoposide When Administered as Up-front Window Therapy to Previously Untreated Children With…
Phase 3 N=464 Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma
Neuroblastoma
Primary: Overall Survival (OS) Rates — 99.4; 93.5; 88.4 percentage of participants
Phase 1 N=5 Study of Donor Derived, Multi-virus-specific, Cytotoxic T-Lymphocytes for Relapsed/Refractory Neuroblastoma
Neuroblastoma
Primary: Number of Participants With Immediate and Short Term Toxicity of Infusion Over 8 Weeks — 0; 0; 3 Participants
Phase 2 N=291 Monoclonal Antibody 3F8 and Sargramostim in Treating Patients With Neuroblastoma
Neuroblastoma
Primary: Efficacy at Completion of Treatment
Phase 2 N=52 Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory Neuroblastoma
Recurrent Neuroblastoma
Primary: Number of Patients With Unacceptable Dose Limiting Toxicities (DLTs) — 1; 2; 9; 18 participants
Phase 2 N=39 hu14.18-Interleukin-2 Fusion Protein in Treating Young Patients With Recurrent or Refractory Neuroblastoma
Neuroblastoma
Primary: Number of Responders (Response Rate) — 0; 5; 13; 18 participants
N/A N=13 High-Risk Neuroblastoma Chemotherapy Without G-CSF
Neuroblastoma
Primary: Incidence of Infection — 6 infections
Phase 3 N=665 Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma
Localized Resectable Neuroblastoma · Localized Unresectable Neuroblastoma · Recurrent Neuroblastoma
Primary: Event-free Survival Rate — 48.8; 61.8 percent probability — p=0.0082
Phase 2 N=42 Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma
Ganglioneuroblastoma · High Risk Neuroblastoma
Primary: Percentage of Participants With Unacceptable Toxicity — 0.0 percentage of patients
Phase 2 N=92 ABT-751 in Treating Children With Neuroblastoma That Has Relapsed or Not Responded to Previous Treatment
Disseminated Neuroblastoma · Recurrent Neuroblastoma
Primary: Median Time to Progression as Assessed by Response Evaluation Criteria in Solid Tumors — 45; 42 days
Phase 1 N=18 TPI 287 in Patients With Refractory or Recurrent Neuroblastoma or Medulloblastoma
Neuroblastoma · Medulloblastoma · Relapse
Primary: Number of Participants With Adverse Events as a Measure of Safety and Tolerability — 14 participants
Phase 2 N=15 Thalidomide and Temozolomide in Relapsed or Progressive CNS Disease or Neuroblastoma
Central Nervous System Tumor, Pediatric · Neuroblastoma
Primary: Therapy Completion Rate — .40 proportion of participants
Phase 2 N=26 Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
Medulloblastoma · Neuroectodermal Tumor
Primary: 12 Month Progression-free Survival (PFS-12) — 215; 69 Days — p=0.927
Phase 3 N=413 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor
Brain and Central Nervous System Tumors
Primary: Progression-Free Survival (PFS) in ERBB2-Negative Tumors Compared to ERBB2-Positive Tumors — 79.2; 83.3; 69.6; 86.7 probability of PFS at 2 years — p=0.8001
N/A N=69 Anti-GD2 3F8 Monoclonal Antibody and GM-CSF for High-Risk Neuroblastoma
Neuroblastoma
Primary: Therapeutic Response — 40; 3; 1; 6 Participants
Phase 2 N=73 Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma
Ganglioneuroblastoma · Recurrent Neuroblastoma
Primary: Percentage of Randomized Patients Who Are Responders — 5.6; 52.9 Percentage of patients
Phase 2 N=112 Study of Nifurtimox to Treat Refractory or Relapsed Neuroblastoma or Medulloblastoma
Neuroblastoma · Medulloblastoma
Primary: Number of Participants With Related Adverse Events as a Measure of Safety and Tolerability — 45 Participants