Phase 4 N=40 Effects of Modafinil in Methamphetamine Dependence
Methamphetamine Dependence
Primary: Percentage of Participants With Methamphetamine-positive Urine Drug Screens — 85; 65 Percentage of participants
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Phase 2 N=73 Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
Cocaine-Related Disorders
Primary: Cocaine Use as Assessed by the Treatment Effectiveness Score (TES), Which is the Total Number of Cocaine-negative Urines During Treatment — 9.25; 6.09; 6; 4.91 number of…
Phase 2 N=81 A Placebo-Controlled Study of Mixed Amphetamine Salts and Topiramate for the Treatment of Cocaine Dependence
Cocaine Dependence
Primary: Three Weeks of Continuous Cocaine Abstinence as Measured by Urine Toxicology and Self Report Based on Time Line Follow Back — 13; 7 participants — p==.05
Phase 2 N=81 Medications for Stopping Cocaine Dependence and Preventing Relapse
Cocaine Abuse · Cocaine-Related Disorders
Primary: Mean Percentage of Cocaine-positive Urines Over Course of 12 Week Treatment in Subgroup Achieving Abstinence at Baseline — 31; 28; 47; 35 Mean % of cocaine-positive urines
Phase 2 N=43 Treatment of Cocaine Dependence With Lisdexamfetamine
Cocaine Dependence
Primary: Cocaine-positive Urine Results — 86.5; 92.4 percentage of BE urine tests
Early Phase 1 N=18 Impact of Sustained Release d-Amphetamine on Choice Between Cocaine and a Non-Drug Reinforcer
Active Cocaine Users
Primary: The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — 0.06; 0.94; 0.75; 0.88 cocaine choices
Phase 3 N=127 Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
Cocaine Dependence
Primary: Three Weeks of Cocaine Abstinence at End of Study — 9; 0 Participants
Phase 1 N=8 Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
Methamphetamine Use Disorder
Primary: Reinforcing Effects of Methamphetamine Following Methylphenidate (0 mg; Placebo) Maintenance. — 0; 0; 3.33; 7.25 Trials Completed
N/A N=40 Bupropion in the Treatment of Methamphetamine Dependence
Methamphetamine Use Disorder
Primary: Estimate the Treatment Effect of Bupropion for Methamphetamine (Meth) Dependence. — 5.6; 6.0 days
Phase 2 N=91 Pharmacotherapy & CM for Opioid and Cocaine Dependence
Cocaine Dependence
Primary: Average Number of Positive Urine Tests — 32; 30.2; 28.1; 31.4 urine tests
N/A N=106 Cocaine Withdrawal and Pharmacotherapy Response
Cocaine Dependence · Opiate Dependence
Primary: Percent Days Abstinent From Cocaine - Self Report — 72.9; 72.9; 59.3 percentage of days — p=.10
Phase 2 N=35 Studying Amphetamine Withdrawal in Humans
Methamphetamine Dependence
Primary: Measure of Methamphetamine Withdrawal — 3.7283; 10.056 units on a scale
Phase 2 N=52 Varenicline for Methamphetamine Dependence
Methamphetamine Dependence · Substance Abuse · Methamphetamine Abuse
Primary: End of Treatment Abstinence — 5; 4 Participants
Phase 2 N=31 Carvedilol for Psychostimulant Dependence
Cocaine Dependence · Cocaine Withdrawal
Primary: Urine Toxicology Screens — 38.33; 41.85 percentage of cocaine negative urines — p=0.05
Phase 2 N=118 Disulfiram for Cocaine Abuse
Cocaine Dependence
Primary: Cocaine Use Over Time — 0.01; 0.007; -0.01; 0.007 slope (change in prob of coc-pos utox/d) — p=<0.05
N/A N=8 Characterizing Methamphetamine Withdrawal in Recently Abstinent Methamphetamine Users: A Pilot Study
Methamphetamine Dependence · Methamphetamine Withdrawal
Primary: Methamphetamine Selective Severity Assessment (MSSA) — 48.2 "units on a scale" — p=<0.05
Phase 2 N=81 Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Cocaine-Related Disorders
Primary: Weekly Cocaine Use — 1.1; 1.3 days
Phase 2 N=28 Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients
Cocaine Dependence · Opioid Dependency
Primary: Change of Thrice Weekly Cocaine Free Urine Toxicology From Week 1 to 13 — 6; 0; 3; 2 participants that were cocaine free — p=0.09
Phase 1 N=30 Reinforcing Effects of Cocaine During Phendimetrazine Maintenance
Cocaine Use Disorder
Primary: Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative — .34; .24; 4.31; 3.9 Cocaine Choices
Phase 3 N=126 Study of Adderall-XR for the Treatment of Adult Attention Deficit Hyperactivity Disorder and Cocaine Dependence
Adult Attention Deficit Hyperactivity Disorder · Cocaine Dependence
Primary: Last Three Weeks of Cocaine Abstinence Based on Urine Toxicology Results and Self Reported Use — 7; 18; 30 percentage of participants
Phase 2 N=71 Modafinil vs Placebo for the Treatment of Methamphetamine Dependence
Methamphetamine Dependence
Primary: Clean Urine Drug Screen — 13.1; 12.7 Clean urine drug screens
Phase 2 N=140 Topiramate for the Treatment of Methamphetamine Dependence - 1
Methamphetamine
Primary: Abstinence (Weeks 6 - 12) — 49; 49; 43; 48 Participants
N/A N=31 Efficacy of Varenicline in Methadone-Stabilized Cocaine Users
Cocaine Dependence · Nicotine Dependence
Primary: Proportion of Cocaine Positive Urine Tests Per Week — .57; .58 Proportion of cocaine positive — p=0.84
Phase 2 N=17 Open-Label Pilot Study of Lisdexamfetamine for Cocaine Dependence
Cocaine Dependence
Primary: Number of Participants Maintained on the Maximum Lisdexamfetamine Daily Dose. — 12 Participants
Phase 2 N=13 Clinical Efficacy of Atomoxetine for Methamphetamine Dependence
Methamphetamine Dependence
Primary: Time Till Relapse — 7; -8 Days to Relapse — p=<0.05
Phase 2 N=210 Modafinil Treatment for Cocaine-Dependent Individuals
Cocaine-Related Disorders
Primary: Urine Toxicology for Cocaine — 3; 8; 3 Participants
Phase 2 N=20 Varenicline vs Placebo for the Treatment of Methamphetamine Dependence
Methamphetamine Dependence · Substance Abuse · Methamphetamine Abuse
Primary: Change in MA Positive Urine Drug Screens Among Participants Randomly Assigned to Receive Varenicline Versus Placebo. — 7.4; 2.3 total MA-free urine drug screens
Phase 1 N=12 An Assessment of the Safety of Varenicline in Methamphetamine-dependent Volunteers
Methamphetamine Addiction · Crystal Meth Addiction · Amphetamine Addiction
Primary: Systolic Blood Pressure — 126.4; 127.4 mm Hg
Phase 2 N=13 Modafinil for Smoked Cocaine Self-Administration
Cocaine Dependence
Primary: Cocaine Self-administration — 0; 0; 0; 2.2 Number of doses purchased
Phase 3 N=104 Citicoline Treatment of Methamphetamine Dependence
Methamphetamine Dependence
Primary: Methamphetamine Dependent Subjects Treated With Citicoline vs Placebo — 0.3025; 0.3850 total amount consumed in grams