N/A N=32 Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Concussion, Mild · Post-Concussion Symptoms · Sleep Problems
Primary: Performance on Multiple Sleep Latency Test (MSLT) — 6.67; 7.32; 6.73; 7.88 minutes
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=120 Neurocognitive Evaluation of Mild Traumatic Brain Injury in the Hospitalized Pediatric Population
Mild Traumatic Brain Injury · Concussion
Primary: The Feasibility of Inpatient Bedside Neurocognitive Testing of Pediatric Patients With Minor Traumatic Brain Injury. — 120 participants
N/A N=79 Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Traumatic Brain Injury (TBI)
Primary: Number of Headache Days Per Week — 4.2; 4.6; 3.1; 4.3 days/week — p=<0.000
N/A N=477 Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
Concussion · Traumatic Brain Injury
Primary: MRI Image Data Sets — 79; 150; 290; 111 Images collected
Phase 2 N=79 Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)
Post-concussive Symptoms · Traumatic Brain Injury
Primary: Post-Intervation Post-concussion Symptom Scores Using RPQ - Intent to Treat — 3.5; 5.1; 4.2; 3.5 units on a scale
N/A N=33 rTMS to Improve Cognitive Function in TBI
Traumatic Brain Injury
Primary: Trail Making Test Part B — 52.1; 45.3; 52.9; 50.8 T-score
N/A N=50 Enhanced Problem-Solving Training
Brain Concussion
Primary: Brief Symptom Inventory-18 (BSI-18) Global Severity Index T-Score — 64.21; 65.26; 66.8; 61.35 units on a scale — p=.04
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
N/A N=40 Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Traumatic Brain Injury · Post Concussive Symptoms · Depression
Primary: Examiner Score — 0.617; 0.907; 0.865; 1.155 score on a scale
N/A N=203 Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Mild Traumatic Brain Injury · Balance; Distorted · Gait, Unsteady
Primary: Dizziness Handicap Inventory (DHI) — 29.2; 34.9; 33.3; 32.1 score on a scale — p=0.013
N/A N=53 LED Therapy for the Treatment of Concussive Brain Injury
Brain Concussion
Primary: Mean Difference in Change in Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) Score at Baseline and 6 Weeks. — -0.9; -5.78; 3.52; -7.26 Units on a scale
N/A N=55 Cognitive-Behavioral Therapy for Veterans With TBI
Insomnia · Traumatic Brain Injury
Primary: Change in Insomnia Severity — 8.833; 7.810; 9.625; 8.364 score on a scale
N/A N=134 Vestibular Consequences of Blast-related Mild Traumatic Brain Injury (TBI)
Dizziness · Brain Injury
Primary: Peripheral Vestibular Function (Vestibulo-ocular Reflex/Semicircular Canal): Caloric Weakness — 8.8; 14.7; 12.3; 7.1 percentage of caloric weakness
N/A N=99 Approaches to Auditory Rehabilitation for Mild Traumatic Brain Injury
Traumatic Brain Injury
Primary: Competence Score From the Psychosocial Impact of Assistive Devices Scale (PIADS) — 0.56; .37; .62; .41 units on a scale — p=0.527
N/A N=30 Adjunctive Pregnenolone in Veterans With Mild TBI
Traumatic Brain Injury
Primary: Brief Assessment of Cognition in Affective Disorders (BAC-A) — 0.61; 0.80 units on a scale
Phase 2 N=71 mTBI Mechanisms of Action of HBO2 for Persistent Post-Concussive Symptoms
Traumatic Brain Injury With Brief Loss of Consciousness · Post-Concussion Syndrome
Primary: Summary of Treatment-Emergent Adverse Events — 13; 5; 5; 3 Participants
N/A N=77 Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
Concussion, Mild · Post-Concussion Symptoms · Sleep Problems
Primary: Sleep Quality - Pittsburgh Sleep Quality Index (PSQI) — 1.28; 1.35 score on a scale
N/A N=66 Transcranial Electrical Stimulation for mTBI
Mild Traumatic Brain Injury (mTBI) · Post-traumatic Stress Disorder
Primary: Change in Abnormal Magnetoencephalography (MEG) Slow-Waves (1-4 Hz) Activity — 1.8; 0.2; 0 units on a scale — p=0.01
Early Phase 1 N=35 Remediation of Impaired Self-Regulation in Patients With Mild TBI
Mild Traumatic Brain Injury
Primary: Blood Oxygen Level Dependent (BOLD) Brain Signal Measured Using Functional MRI. — 270; 111 voxels — p=<0.0001
N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
N/A N=68 Light Therapy for Moderate Traumatic Brain Injury
Moderate Traumatic Brain Injury (TBI)
Primary: Safety and Feasibility of Applying Light Therapy After Moderate TBI — 24; 19 Participants
N/A N=29 Improving Functions in MTBI Patients With Headache by rTMS
TBI (Traumatic Brain Injury)
Primary: Percent Change in Composite Score of Debilitating Headache (Intensity x Duration x Frequency) — -55.3; -1.7; -58.4; -10 percent change from baseline — p=<0.0001
Phase 2 N=50 Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
Brain Injury, Chronic
Primary: Computer Cognitive Test Scores - ImPACT Verbal Memory — 70.48; 74.21; 78.12; 75.36 units on a scale
N/A N=6 Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
TBI (Traumatic Brain Injury)
Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time
N/A N=105 Mindfulness-Based Cognitive Therapy Intervention to Treat Depression in Individuals With a Traumatic Brain Injury
Depression · Traumatic Brain Injury
Primary: Beck Depression Inventory - II — 25.47; 27.13; 18.84; 25.00 units on a scale
N/A N=26 Eye Movement Recordings in the Diagnosis of Traumatic Brain Injury
Traumatic Brain Injury
Primary: Stability of Fixation — 0.8; 1.1 degrees
N/A N=27 Yoga and Female Concussion
Concussion Mild
Primary: Post Traumatic Growth — 41.7; 57.8; 40.4; 60.7 Score on a scale
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
Phase 4 N=26 Methylphenidate for Attention Problems After Pediatric TBI
Traumatic Brain Injury · TBI · ADHD
Primary: Parent Outcome-Vanderbilt ADHD Parent Rating Scales (VADPRS) — 1.10; 1.47; .84; 1.14 units on a scale
N/A N=46 Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
Post Traumatic Stress Disorder · Mild Traumatic Brain Injury, Concussion
Primary: Change in Performance on Neurocognitive Measure of Attention and Executive Function Post GOALS Intervention vs EDU Control Training — -0.03; -0.39 z score — p=<0.01