N/A N=386 Clinical Use of a Neonatal MRI System
NICU MRI
Primary: Number of Participants With Adverse Events as Observed During and After Scanning. — 0 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=657 Clinical Use of a New Neonatal MRI System
Magnetic Resonance Imaging
Primary: Number of Participants With Adverse Events as Observed During and After Scanning. — 4 Participants
N/A N=49 Development of a MR Scanner Capable of Being Sited in a Neonatal Intensive Care Unit (Firefly Sheffield)
Neonatal Neuroimaging
Primary: Image Diagnostic Quality for Phase 1 — 24 Participants
N/A N=15 Pilot Study: Safety of a Customized MRI System for Neonatal Imaging
Safety of a Customized NICU MRI System
Primary: Number of Participants With Adverse Events as Measured by Vital Signs, Change in Temperature, and Physical Exam — 0 Adverse Events
N/A N=45 MRI for Non-Invasive Imaging in Neonates and Children
Healthy · Cystic Fibrosis (CF) · Asthma
Primary: Ventilation Defects as Seen on Hyperpolarized Helium-3 MRI — 9; 13; 16 Participants
Phase 3 N=1 CEUS Evaluation of Hypoxic Ischemic Injury
Hypoxic-Ischemic Encephalopathy · Brain Ischemia Hypoxia
Primary: Detection of Brain Perfusion Abnormalities Using Contrast-enhanced Ultrasound — 1; 0 Participants
Phase 4 N=74 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine
Apnea of Prematurity · Intraventricular Hemorrhage · Brain Injury
Primary: White Matter Microstructural Maturation — 1.43; 1.42 apparent diffusion coefficient
N/A N=63 Prospective Research in Infants With Mild Encephalopathy
Hypoxic-Ischemic Encephalopathy · Brain Injury · Neonatal Seizure
Primary: Percentage of Infants With Evidence of Neurological Dysfunction, Brain Injury and/or Abnormality. — 28 Participants
N/A N=70 NEO Rehab Program for Premature Infants at Risk for Cerebral Palsy
Cerebral Palsy · Prematurity · Early Intervention
Primary: Acceptability — 70 Participants
N/A N=34 Cardiac and Cerebral Hemodynamics With Umbilical Cord Milking Compared With Early Cord Clamping
Birth Asphyxia With Neurologic Involvement
Primary: StO2 in the First 10 Minutes of Life — 70; 74.5 percent
N/A N=100 The Developmental Effects of NICU Positioning
Premature Birth of Newborn
Primary: NICU Network Neurobehavioral Scale (NNNS) — 3.1; 2.56 Asymmetry Score (units on a scale)
N/A N=111 Cerebral Oxygenation and Autoregulation in Preterm Infants
Intraventricular Hemorrhage of Prematurity · Complications of Prematurity
Primary: Mortality Before Hospital Discharge — 11 Participants
N/A N=77 Brain Imaging and Developmental Follow up of Infants Treated With Erythropoietin
Prematurity
Primary: Full Scale IQ, Performance IQ, Verbal IQ, Executive Function — 79; 91; 103; 83 standardized score on a scale
N/A N=11 Therapeutic Intervention Supporting Development From NICU to 6 Months for Infants Post Hypoxic-Ischemic Encephalopathy
Cerebral Palsy · Hypoxic-Ischemic Encephalopathy
Primary: Feasibility of the Neonatal Intensive Care Unit Component of the Intervention. — 0; 1 Participants
N/A N=35 NIRS Monitoring to Detect AKI in Preterm Infants
Acute Kidney Injury · Premature Infant
Primary: Renal NIRS Tissue Oxygenation Differential — 60; 32.4; 62.5; 44.4 percentage saturation — p=<0.001
N/A N=20 Perinatal Stroke: Understanding Brain Reorganization
Stroke · Hemiparesis
Primary: Cortical Excitability MEP Amplitude (µV) — 325 µV
N/A N=73 Rapid MRI for Acute Pediatric Head Trauma
Head Trauma · Image, Body
Primary: Sensitivity: Percentage of MRIs Correctly Identifying Clinically Important Intracranial Injury (True Positives) — 70 Percentage of MRIs correctly identifying
Phase 2 N=62 Erythropoetin Neuroprotection for Neonatal Cardiac Surgery
Congenital Heart Disease · Hypoplastic Left Heart Syndrome · Transposition of the Great Arteries
Primary: Relative Difference in Total Maturity Score (TMS) From Preoperative Brain MRI to 7 Day Postoperative MRI — 12.1; 9.44 Percentage
N/A N=248 Trial to Improve Multisensory Neural Processing, Language & Motor Outcomes in Preterm Infants
Preterm Infant
Primary: Index of Multisensory Processing (IMP) — 31.4; 49.0; 35.6; 18.8 percentage of time
N/A N=39 Fetal and Neonatal Magnetophysiology
Fetal Arrhythmia · Abnormality in Fetal Heart Rate or Rhythm · Long QT Syndrome
Primary: Percentage of Subjects Experiencing Symptoms — 0; 0 Participants
N/A N=11 Magnetic Resonance Imaging Using Innovative Pulse Sequences
Clinical Indication for a Head MRI
Primary: Number of Head Images Successfully Collected — 10 Images
N/A N=144 Integrated Predictive Monitoring for Sepsis and Necrotizing Enterocolitis
Sepsis · Necrotising Enterocolitis Neonatal
Primary: Number of Participants With Sepsis or Necrotizing Enterocolitis — 20; 124 Participants
Phase 3 N=20 Contrast-enhanced MRI in Children 2 Months to <2 Years
Magnetic Resonance Imaging
Primary: Number of Participants With Diagnostic Adequacy - Open-label Clinical Investigators (Per Protocol Set) — 1; 0; 2; 3 Participants
N/A N=48 NICU Oxygen Control Study
Hyperoxia · Hypoxia
Primary: Elapsed Time to Respond to SpO2 Alarm — 51.408; 41.523 seconds — p=0.003
N/A N=605 Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU)
Neurodevelopmental Abnormality
Primary: Total and Domain Scores on the Ages and Stages Questionnaire, Third Edition. — 55; 55; 60; 60 score on a scale — p=0.87
N/A N=106 Echocardiography Sub-Study of the Umbilical Cord Milking in Non-Vigorous Infants Trial (MINVI)
Birth Asphyxia
Primary: Left Ventricular Output — 225; 187 mL/kg/min — p=0.08
Phase 1 N=22 PED NEONAT 20-000599 Fetal Body Composition
IUGR · Gestational Diabetes · Pregnancy Related
Primary: Maternal Visceral Adipose Tissue Volume — 97593; 169626; 96787 mm3
N/A N=514 Neonatal Intensive Care Unit Virtual Family-Centered Rounds
Pediatric Disorder · Neonatal Disease
Primary: Parent FCR Attendance — 0.56; 0.12 proportion of encounters
Phase 2 N=256 Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury
Intraventricular Hemorrhage · Periventricular Leukomalacia · Brain Injury
Primary: Percent of Survivors With no Severe IVH (Grades 3 or 4) or PVL — 22.2; 14.9; 17.1; 10.9 percent of participants
N/A N=169 Comparative Effectiveness Trial for Diagnosis of Necrotizing Enterocolitis
Necrotizing Enterocolitis
Primary: Days to Full Enteral Feeds: Extended Rule Out Group — 10.1; 4.9 days