N/A N=110 Saypha® Volume LIdocaine in Nasolabial Folds
Moderate to Severe Nasolabial Folds
Primary: Responder Rate in Reduction of Nasolabial Folds — 34; 39; 73 Participants
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N/A N=62 Princess® VOLUME Lidocaine for the Correction of Nasolabial Folds
Nasolabial Fold, Hypoplastic
Primary: NLF-SRS Grade of Nasolabial Folds Change — -1.50 score on a scale
Phase 4 N=100 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color
Nasolabial Folds
Primary: Number Participants With Hypertropic Scarring, Keloid Formation, Hyper- or Hypopigmentation in Patients With Fitzpatrick Skin Types IV, V, and VI Receiving Nasolabial…
N/A N=20 Perioral Rejuvenation and Upper Lip Enhancement
Perioral Rejuvenation · Upper Lip Projection
Primary: Nasal Tip Projection — 0.601 ratio
N/A N=175 Restylane Defyne Compared to Restylane for Correction of Moderate to Severe Nasolabial Folds
Nasolabial Folds in Chinese Population
Primary: Percentage of Responders, Defined by at Least 1-point Improvement From Baseline on the WSRS. — 72.9; 72.8 percentage of subjects
N/A N=80 Safety and Effectiveness of Sculptra Aesthetic for Correction of Nasolabial Folds.
Nasolabial Folds
Primary: Change in Wrinkle Assessment Scale (WAS) Score — -1.3; -1.3; -1.2; -1.3 units on a scale
N/A N=181 Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Nasolabial Folds in China
Correction of the Moderate to Severe Nasolabial Folds
Primary: Percentage of NLFs With Treatment Success at Month 6 — 66.0; 72.8 Percentage of successfully treated NFLs
N/A N=270 Effectiveness and Safety of Princess FILLER Lidocaine in Correction of Nasolabial Folds (NLF)
Dermatological Non-Disease
Primary: Responder Status Based on Independent Evaluating Investigator Live Assessment at Week 24 - Full Analysis Dataset — 222; 221 Participants — p=<0.0001
N/A N=148 Restylane Defyne for Correction of Chin Retrusion
Chin Retrusion
Primary: Percentage of Participants (Responders) With At Least 1-Point Improvement From Baseline on the GCRS, as Assessed by the Blinded Evaluator at Month 6 ([Baseline…
N/A N=205 Sculptra for Correction of Midface Volume Deficit and/or Midface Contour Deficiency
Midface Volume Deficit
Primary: Percentage of Participants With 1 Point Improvement From Baseline on the Medicis Midface Volume Scale (MMVS) as Measured by the Blinded Evaluator at Month 12 — 68.8…
N/A N=126 A Safety and Effectiveness Study of JUVÉDERM VOLIFT® XC Versus Control for Moderate to Severe Nasolabial Folds
Moderate to Severe Nasolabial Folds
Primary: Mean Change From Baseline in Nasolabial Fold Severity Using the 5-Point Nasolabial Fold Severity Scale (NLFSS) — 2.6; 2.6; 1.4; 1.3 Scores on a Scale
N/A N=20 A Study to Evaluate the Performance and Safety of GP0045 for Correction of Moderate to Severe Nasolabial Folds
Nasolabial Fold · Safety
Primary: Response Rate in Treatment of Nasolabial Fold (NLF) Based on a Scale — 63.2; 68.4 percentage of participants
Phase 2 N=145 Evaluation of the Safety and Efficacy of CosmetaLife™ for the Correction of Nasolabial Folds
Facial Wrinkles
Primary: Change in Wrinkle Severity Rating Scale — -0.94; -1.07 units on scale
N/A N=60 Post Market Study Evaluating Princess Filler Lidocaine for the Correction of Nasolabial Folds
Correction of Nasolabial Folds
Primary: Change From Baseline in Average Nasolabial Folds-Severity Rating Scale (NLF-SRS) Grade Based on Investigator Assessment at Week 24 — -1.8 score on a scale
N/A N=102 Evaluation of Pain With Radiesse® With Lidocaine for Nasolabial Folds
Nasolabial Folds
Primary: Pain Score Using a 10-cm Visual Analog Scale (VAS) for Pain (0 = no Pain, 10 = Very Severe Pain) — 2.32; 6.73 units on a scale — p=<0.0001
Phase 4 N=32 Juvederm Ultra With Lidocaine Compared With Restylane for the Correction of Nasolabial Folds
Nasolabial Folds
Primary: Procedural Pain Score — 2.0; 4.1 units on a scale
N/A N=118 TEOSYAL® RHA Ultra Deep and Perlane-L® for the Correction of Nasolabial Folds
Nasolabial Folds, Wrinkles
Primary: Non-inferiority of the Delta of the WSRS Score Between W24 and Baseline for TEOSYAL® RHA Ultra Deep Versus Perlane-L® for the Correction of Moderate to Severe…
N/A N=100 Efficacy and Safety of Restylane Perlane Compared to Restylane for Correction of Moderate and Severe Nasolabial Folds
Nasolabial Folds in Chinese Population
Primary: Mean Change From Baseline in Wrinkle Severity Rating Scale (WSRS) at 6 Months — -0.03; 0.03 units on a scale
N/A N=110 Clinical Study for the Evaluation of the Safety and Effectiveness of Use of a Poly-L Lactic Acid Injectable Filler for the Aesthetic Treatment of Nasolabial Folds
Wrinkle
Primary: Change From Baseline in the Nasolabial Folds Severity Score on the Wrinkle Severity Rating Scale (WSRS) 6 Months After Treatment — -0.3; -0.2; -0.1 score on a scale
N/A N=121 Evaluation of the Effectiveness and Safety of Radiesse for the Correction of Moderate to Severe Nasolabial Folds
Correction of Moderate to Severe Nasolabial Folds (NLFs)
Primary: Change From Baseline to Week 24 on the Wrinkle Severity Rating Scale (WSRS) — 3.4; 3.4; 2.4; 2.4 score on a scale
Phase 3 N=118 Multicenter Study of the Safety and Effectiveness of Dermal Filler, Belotero®.
Facial Wrinkles
Primary: Adjusted (LS) Mean Change From Baseline in Wrinkle Severity Rating Scale (SRS) Score of Each Nasolabial Fold (NLF) as Determined by the Blinded Evaluator at Week 12…
Phase 3 N=203 Safety and Efficacy Study of Isolagen TherapyTM in the Treatment of Nasolabial Fold Wrinkles
Bilateral Nasolabial Fold Wrinkles
Primary: Subject Wrinkle Assessment Responders — 57; 31 participants — p=.00001
Phase 3 N=218 Safety and Efficacy Study of Isolagen Therapy in the Treatment of Nasolabial Fold Wrinkles
Bilateral Nasolabial Fold Wrinkles
Primary: Subject Wrinkle Assessment Responders — 50; 19 participants — p=<.00001
N/A N=131 Restylane Perlane to Shape the Nasal Dorsum and/or Nasal Root
Nasal Augmentation
Primary: Mean Difference of Change in Volume (mL) at 6 Months After Baseline Versus Pre-treatment in the Nasal Dorsum/Nasal Root Between Restylane Perlane Treatment Group and…
N/A N=333 Restylane-L for Correction of Infraorbital Hollows
Infraorbital Hollows
Primary: Responder Rate Based on the Blinded Evaluator's Live Assessment of the Galderma Infraorbital Hollows Scale (GIHS) — 87.4; 17.7 Percentage of participants — p=<0.001
N/A N=70 Post-Market Study of JUVÉDERM VOLIFT™ With Lidocaine for the Correction of Nasolabial Folds
Moderate to Severe Nasolabial Folds
Primary: Investigator Assessment of Nasolabial Fold Severity Using the 5-point Nasolabial Fold Severity Scale (NLFSS) — 2.8; 2.8 Scores on a Scale
Phase 2 N=15 Pilot Evaluation of Platelet Rich Fibrin Matrix (PRFM) for the Correction of Nasolabial Folds
Nasolabial Folds
Primary: Difference in Wrinkle Assessment Score, Between Pre-treatment and 12 Weeks Post-treatment. — 1.13 units on a scale
N/A N=29 JUVÉDERM VOLUMA® to Enhance the Appearance of the Asian Nose
Asian Nose Enhancement
Primary: Percentage of Participants With a ≥ 1 Grade Improvement on the Assessment of Aesthetic Improvement Scale (AAIS) as Assessed by the Central Evaluating Physician at Day…
N/A N=58 Clinical Study to Evaluate the Correction of Wrinkles and Folds and Safety of YVOIRE Classic Versus Restylane in Nasolabial Fold Intradermal Injection
Temporary Correction of Wrinkles
Primary: Average of Wrinkle Severity Rating Scale (WSRS) Score Evaluated by the Evaluating Investigator at Week 26 (Visit 7) After the Final Treatment With the Investigational…
N/A N=147 TEOSYAL® RHA Global Action, TEOSYAL® RHA Deep Lines, and Juvéderm® Ultra XC for the Correction of Nasolabial Folds
Nasolabial Folds, Wrinkles
Primary: Non-inferiority of the Delta of TEOSYAL® RHA GA and TEOSYAL® RHA DL Versus Juvéderm® Ultra XC for the Correction of Moderate to Severe NLFs Based on the Wrinkle Severity…