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N/A N=92

Past Pain Experience and Perception of Experimental Pain

Schizophrenia · Major Depression

Enrolled (actual)
92
Serious AEs
0.0%
Results posted
May 2017
Primary outcome: Primary: Visual Analog Scale Evaluation for the Pre-fixed Pressure Test — 2.8; 2.1; 1.2 units on a scale — p=0.121

Study Design & Population

Study type
Observational
Phase
N/A
Interventions
experimental pain tests (Other)
Age
Adult · 18+ yrs
Sex
All
Sponsor
Centre Hospitalier Esquirol
Primary completion
Jan 2014

Outcome Measures

OutcomeResultp-value
PRIMARY
Visual Analog Scale Evaluation for the Pre-fixed Pressure Test
2.8; 2.1; 1.2 0.121

Summary

Differences in pain perception between subjects with and without psychiatric illness may be influenced by the individual experience, and not primarily by the pathology, although the pathological frame may amplify it.The aim of this study is to establish if the characteristics of experimental pain feeling are influenced by the past pain experience, anxiety and emotion, independently from the diagnosis. The pain experience will be evaluated by an inventory of the potentially painful situations that one can come across through the life, to determine the following points : Number of painful events in the past, number of painful points during the last 6 months, number of painful events lasting more than 6 months, sum of pain intensities (graduated with Visual Analogic Scale VAS from 0 to 10), sum of gravity (evaluated from 0 to 5), the category of pain experience qualification (mostly affective, mostly sensorial, or both). Schizophrenic, depressed and control participants will be recruited, and their pain experience throughout life will be put it in relation to experimental pain tests results (pressure application, ischemia induction), anxiety and emotion (Hospital Anxiety and Depression scale HAD), catastrophizing (Pain Catastrophizing Scale PCS), Heart Rate (HR) variation, Blood Pressure (BP) variation.

Eligibility Criteria

Inclusion Criteria

  • subjects with psychiatric trouble : diagnosis of schizophrenia or major depression according to the DSM-IV-TR criteria.
  • control subjects : without known psychiatric history.
  • age between 18 and 60.

Exclusion Criteria

  • absence of consent, hospitalization under constraint, absence of health insurance.
  • inability to answer the questionnaires
  • pregnancy
  • antalgic or analgesic treatment
  • allergy to latex
  • non stabilized high blood pressure, bad blood coagulation,
  • peripheral neuropathy, nerve lesion, dermatosis at the superior extremities, muscular lesion or pathology at the upper member level
  • non treated alcohol dependence
  • illegal substance consumption in the past 48 hours
  • participation to an other biomedical study during the 2 weeks before inclusion, and until the pain tests, if this study can interfere with the realization of the objectives
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01575912). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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