N/A
N=92
Past Pain Experience and Perception of Experimental Pain
Schizophrenia · Major Depression
Bottom Line
View on ClinicalTrials.gov: NCT01575912 ↗Enrolled (actual)
92
Serious AEs
0.0%
Results posted
May 2017
Primary outcome: Primary: Visual Analog Scale Evaluation for the Pre-fixed Pressure Test — 2.8; 2.1; 1.2 units on a scale — p=0.121
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- experimental pain tests (Other)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Centre Hospitalier Esquirol
- Primary completion
- Jan 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Visual Analog Scale Evaluation for the Pre-fixed Pressure Test |
2.8; 2.1; 1.2 | 0.121 |
Summary
Differences in pain perception between subjects with and without psychiatric illness may be influenced by the individual experience, and not primarily by the pathology, although the pathological frame may amplify it.The aim of this study is to establish if the characteristics of experimental pain feeling are influenced by the past pain experience, anxiety and emotion, independently from the diagnosis. The pain experience will be evaluated by an inventory of the potentially painful situations that one can come across through the life, to determine the following points : Number of painful events in the past, number of painful points during the last 6 months, number of painful events lasting more than 6 months, sum of pain intensities (graduated with Visual Analogic Scale VAS from 0 to 10), sum of gravity (evaluated from 0 to 5), the category of pain experience qualification (mostly affective, mostly sensorial, or both).
Schizophrenic, depressed and control participants will be recruited, and their pain experience throughout life will be put it in relation to experimental pain tests results (pressure application, ischemia induction), anxiety and emotion (Hospital Anxiety and Depression scale HAD), catastrophizing (Pain Catastrophizing Scale PCS), Heart Rate (HR) variation, Blood Pressure (BP) variation.
Eligibility Criteria
Inclusion Criteria
- subjects with psychiatric trouble : diagnosis of schizophrenia or major depression according to the DSM-IV-TR criteria.
- control subjects : without known psychiatric history.
- age between 18 and 60.
Exclusion Criteria
- absence of consent, hospitalization under constraint, absence of health insurance.
- inability to answer the questionnaires
- pregnancy
- antalgic or analgesic treatment
- allergy to latex
- non stabilized high blood pressure, bad blood coagulation,
- peripheral neuropathy, nerve lesion, dermatosis at the superior extremities, muscular lesion or pathology at the upper member level
- non treated alcohol dependence
- illegal substance consumption in the past 48 hours
- participation to an other biomedical study during the 2 weeks before inclusion, and until the pain tests, if this study can interfere with the realization of the objectives
Data sourced from ClinicalTrials.gov (NCT01575912). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.