N/A N=212 Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Intrauterine Resuscitation
Primary: Umbilical Artery Malondialdehyde — 9.8; 10.2 umol/L
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=201 Risk of Oxygen During Cardiac Surgery Trial
Cardiac Surgery
Primary: Intraoperative Systemic Oxidative Damage — 69; 83 pg/ml
Phase 3 N=738 Long-term Oxygen Treatment Trial
Chronic Obstructive Pulmonary Disease
Primary: Death or Hospitalization, Whichever Occurs First — 34.2; 36.4 Composite events/100 person-years — p=0.52
N/A N=114 Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings
Electronic Fetal Monitoring · Fetal Hypoxia · Fetal-Placental Circulation
Primary: Mean Umbilical Artery Lactate at Delivery — 3.5; 3.4 mmol/L — p=0.69
Phase 2 N=19 High-Flow Oxygen for Dyspnea in Hospitalized Cancer Patients
Cancer
Primary: Change in Dyspnea Numeric Score Between 0 and 10 Minutes — -1.8; -1.8; -0.6; -0.5 score on a scale
N/A N=34 Oxygen Reserve Index Validation for RD Lite Sensors
Healthy
Primary: Specificity of ORI to Detect Drops in Oxygenation — 98.50; 96.68; 98.89; 96.95 percentage of true negative
N/A N=60 Effect of Super-Oxygenated Water on Blood Oxygen Saturation
Adult Subject
Primary: SpO2 Response Rate — 21; 11 Participants — p=0.010
N/A N=50 Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Abnormality, Respiratory System · Autonomic Nervous System
Primary: FEV1 — 0.94; 1.08; 0.95; 1.09 percentage of predicted normal values
N/A N=29 Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period
Hypoplastic Left Heart Syndrome · Total Anomalous Pulmonary Venous Return · Truncus Arteriosus
Primary: Systemic Oxidative Stress Based on Thiobarbituric Acid Reactive Substances (TBARS) — 1.21; 1.93; 1.09; 1.77 Fold Change from Baseline — p=<0.01
N/A N=5,749 Supplemental Oxygen in Colorectal Surgery: A Quality Improvement Project
30% Oxygen Concentration During Colorectal Surgery · 80% Oxygen Concentration During Colorectal Surgery
Primary: Number of Participants With One or More Composite Complications — 314; 314 Participants — p=0.85
Phase 3 N=100 Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
Atelectasis
Primary: Oxygen Requirement to Maintain SpO2>90% — 1; 1; 1; 1 liters per minute
N/A N=30 Comparison of Oxygen Delivery Devices for Reversal of Altitude-Induced Hypoxemia in Normal Subjects
Hypoxemia · Hypobaric Hypoxemia
Primary: Return of Oxygen Saturation to Baseline (Sea Level) Values — 6; 8; 10; 4 participants — p=0.3
Phase 4 N=33 Neuroimaging During Pure Oxygen Breathing
Hyperoxia · Hypoxia, Brain · Neurobehavioral Manifestations
Primary: Cerebral Blood Flow — 48.54; 36.17 ml/min/100g tissue — p=<0.05
N/A N=21 Oxygen Saturation Monitoring During Surgery
Sleep Apnea, Obstructive
Primary: Number of Participants With Saturation Pattern Detection (SPD) Indicative of Repetitive Reductions in Air Flow — 4; 0 Participants
N/A N=127 Effect of Oxygen-supply on 6-Minute-Walking-Distance of COPD III/IV-patients
Chronic Obstructive Pulmonary Disease
Primary: Oxygen Response — 26.9 Meter
N/A N=49 The Efficacy of Normobaric Oxygen on Chronic Cerebral Ischemia
Normobaric Oxygen · Cerebral Ischemia
Primary: The Fronto-central Theta Absolute Power Change Rate — 0.14; -0.12 ratio
N/A N=60 Effect of Peri-operative Supplemental Oxygen in Wound Infection After Appendectomy
Perioperative Hyperoxygenation · Wound Infection
Primary: ASEPSIS Score — 30; 30; 0; 0 participants — p=0.5
N/A N=80 Oxygen Reserve Index: Utility as Early Warning for Desaturation in Morbidly Obese Patients
Morbid Obesity · Surgery
Primary: Utility of ORi Providing Added Warning Time — 46.5; 87.0 seconds
N/A N=29 Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
Amyotrophic Lateral Sclerosis (ALS) · Neuromuscular Diseases
Primary: Percent Change in Maximal Inspiratory Pressure (MIP) — 0.3; -3.1; -4.8; -5.0 percentage change in MIP from baseline
N/A N=31 Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation
Respiratory Distress Syndrome in Premature Infants · Very Low Birth Weight Baby
Primary: Maximum Factional Inspired Oxygen Percent (FiO2) — 48; 39 percentage of Inspired Oxygen — p=0.0012
N/A N=91 Oxygen Therapy for the Treatment of Undifferentiated Headache in the Emergency Department
Headache
Primary: Time to Relief (Min) — 92.2; 83.9; 35.4 Minutes
N/A N=300 Supplemental Oxygen Reduces Surgical Infection
Wound Infection
Primary: Incisional Surgical Wound Infection — 22; 35 participants — p=0.04
N/A N=20 Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
Ozone Exposure During Rest and Exercise
Primary: Time-to-exhaustion on Maximal Cycling Bout — 209; 235 seconds — p=0.092
N/A N=206 EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
Diffuse Apneic Oxygenation
Primary: Mean (Average) Arterial Oxygen Saturation — 92; 93 Percent Saturation (SpO2)
N/A N=114,921 Oxygen Therapy Use in Patients With Fibrotic Interstitial Lung Disease
Lung Diseases, Interstitial
Primary: Time to Oxygen Therapy Initiation — 27.5; NA Months
N/A N=22 Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
Sensitivity
Primary: Sensory Function — 46.7; 46.4; 46.1; 45.9 Degrees celsius — p=0.592
N/A N=27 Oxygen Reserve Index (ORi) Validation of INVSENSOR00025
Healthy
Primary: Specificity for Changes in ORi Values as Compared to Corresponding Changes in PaO2 Values. — 94.82; 90.69; 100 percentage of true negatives
N/A N=29 Oxygen Reserve Index (ORi) Expanded Data Set Validation of INVSENSOR00025
Healthy
Primary: Concordance for Changes in ORi Values as Compared to Corresponding Changes in PaO2 Values. — 99.68; 92.94; 91.48 percentage of accuracy
N/A N=30 Oxygen Reserve Index (ORi) Validation of INVSENSOR00029
Healthy
Primary: Sensitivity for Changes in ORi Values as Compared to Corresponding Changes in PaO2 Values. — 93.63 percentage of true positives
N/A N=14 Accuracy of ScanWatch Pulse Oximeter With Profound Hypoxia
Oximetry
Primary: RMSE Compared to CO-oximetry — 2.97; 3.00 RMSE (%)