Phase 3 N=201 Risk of Oxygen During Cardiac Surgery Trial
Cardiac Surgery
Primary: Intraoperative Systemic Oxidative Damage — 69; 83 pg/ml
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=60 Effect of Super-Oxygenated Water on Blood Oxygen Saturation
Adult Subject
Primary: SpO2 Response Rate — 21; 11 Participants — p=0.010
N/A N=1,301 Pragmatic Trial Examining Oxygenation Prior to Intubation
Acute Respiratory Failure
Primary: Incidence of Hypoxemia — 57; 118 Participants
N/A N=114 Oxygen for Intrauterine Resuscitation of Category II Fetal Heart Tracings
Electronic Fetal Monitoring · Fetal Hypoxia · Fetal-Placental Circulation
Primary: Mean Umbilical Artery Lactate at Delivery — 3.5; 3.4 mmol/L — p=0.69
N/A N=212 Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Intrauterine Resuscitation
Primary: Umbilical Artery Malondialdehyde — 9.8; 10.2 umol/L
N/A N=34 Preoxygenation With Optiflow™ - the Effect of Speech on Lung Oxygenation.
Unrecognized Condition
Primary: End Tidal Oxygen Fraction — 43.9; 81.9 percentage of End-Tidal Oxygen Fraction
N/A N=29 Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period
Hypoplastic Left Heart Syndrome · Total Anomalous Pulmonary Venous Return · Truncus Arteriosus
Primary: Systemic Oxidative Stress Based on Thiobarbituric Acid Reactive Substances (TBARS) — 1.21; 1.93; 1.09; 1.77 Fold Change from Baseline — p=<0.01
N/A N=40 Pre-Oxygenation Techniques in Pregnancy
Preoxygenation
Primary: End Tidal Oxygen Concentration (ETO2) Following Tidal Volume Breathing Using Either Face Mask or OptiFlow — 91.0; 87.4 Percentage units of end-tidal oxygen
Phase 3 N=100 Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
Atelectasis
Primary: Oxygen Requirement to Maintain SpO2>90% — 1; 1; 1; 1 liters per minute
N/A N=19 Supplemental Oxygen in Pulmonary Fibrosis
Pulmonary Fibrosis
Primary: Change in University of California San Diego Shortness of Breath Questionnaire From Immediately Prior to One Month After Starting Daily-use Supplemental Oxygen — 0.9…
Phase 1 N=16 Reoxygenation After Cardiac Arrest II (REOX II Study)
Cardiac Arrest
Primary: Plasma Isofurans (pg/mL)/Isoprostanes (pg/mL) Ratio
N/A N=35 Oxygenation Via Frova Bougie and Ambu Bag
Failed or Difficult Intubation
Primary: Tidal Volume (ml) — 954.8; 554.4; 893.5; 542.9 tidal volume (ml)
Phase 2 N=19 High-Flow Oxygen for Dyspnea in Hospitalized Cancer Patients
Cancer
Primary: Change in Dyspnea Numeric Score Between 0 and 10 Minutes — -1.8; -1.8; -0.6; -0.5 score on a scale
N/A N=360 Apneic Oxygenation During Airway Management in Pediatric Patients
Hypoxia
Primary: Time to First Event: Pulse Oximetry at 95%, or Successful Intubation — 106; 169 seconds
N/A N=5,749 Supplemental Oxygen in Colorectal Surgery: A Quality Improvement Project
30% Oxygen Concentration During Colorectal Surgery · 80% Oxygen Concentration During Colorectal Surgery
Primary: Number of Participants With One or More Composite Complications — 314; 314 Participants — p=0.85
Phase 4 N=33 Neuroimaging During Pure Oxygen Breathing
Hyperoxia · Hypoxia, Brain · Neurobehavioral Manifestations
Primary: Cerebral Blood Flow — 48.54; 36.17 ml/min/100g tissue — p=<0.05
N/A N=70 Supplemental Oxygen Study
Cesarean Section · Supplemental Oxygen · Umbilical Cord Gases
Primary: Umbilical Cord pH Levels — 7.29; 7.28 pH
N/A N=114,921 Oxygen Therapy Use in Patients With Fibrotic Interstitial Lung Disease
Lung Diseases, Interstitial
Primary: Time to Oxygen Therapy Initiation — 27.5; NA Months
N/A N=27 Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)
Transposition of the Great Vessels · Hypoplastic Left Heart Syndrome · Oxygen Consumption Based Assessment of Hemodynamics
Primary: Oxygen Consumption — 72; 102 mL oxygen/min/m^2
N/A N=37 Preoxygenation With Nasal Cannula and Noninvasive Positive Pressure Ventilation
Hypoxia
Primary: End-tidal Oxygen — 78.1; 78.6 End tidal oxygen saturation percentage
Phase 3 N=738 Long-term Oxygen Treatment Trial
Chronic Obstructive Pulmonary Disease
Primary: Death or Hospitalization, Whichever Occurs First — 34.2; 36.4 Composite events/100 person-years — p=0.52
N/A N=26 Four Methods of Pre-oxygenation
Respiratory Failure
Primary: Exhaled Oxygen Concentration — 72; 86; 54; 77 % FeO2
N/A N=60 Effect of Peri-operative Supplemental Oxygen in Wound Infection After Appendectomy
Perioperative Hyperoxygenation · Wound Infection
Primary: ASEPSIS Score — 30; 30; 0; 0 participants — p=0.5
N/A N=572 Pilot Study of Targeted Normoxia in Critically Ill Trauma Patients
Trauma · Critical Illness · Oxygen Toxicity
Primary: Patient-time Hyperoxic and Not on Room Air — 40.6; 33.9 Percent patient-time in hyperoxia — p=0.03
N/A N=20 Evaluation of the Delivery of Optimized Supersaturated Oxygen Therapy to Treat Patients With an Acute Heart Attack
Anterior Wall Acute Myocardial Infarction
Primary: The Feasibility of Intracoronary Infusion of SSO2 Therapy — 20 participants
N/A N=27 Oxygen Reserve Index (ORi) Validation of INVSENSOR00025
Healthy
Primary: Specificity for Changes in ORi Values as Compared to Corresponding Changes in PaO2 Values. — 94.82; 90.69; 100 percentage of true negatives
N/A N=206 EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
Diffuse Apneic Oxygenation
Primary: Mean (Average) Arterial Oxygen Saturation — 92; 93 Percent Saturation (SpO2)
N/A N=21 Oxygen Saturation Monitoring During Surgery
Sleep Apnea, Obstructive
Primary: Number of Participants With Saturation Pattern Detection (SPD) Indicative of Repetitive Reductions in Air Flow — 4; 0 Participants
N/A N=31 Inhaled Nitric Oxide (iNO) as an Adjunct to Neonatal Resuscitation
Respiratory Distress Syndrome in Premature Infants · Very Low Birth Weight Baby
Primary: Maximum Factional Inspired Oxygen Percent (FiO2) — 48; 39 percentage of Inspired Oxygen — p=0.0012
N/A N=30 Oxygen Reserve Index (ORi) Validation of INVSENSOR00029
Healthy
Primary: Sensitivity for Changes in ORi Values as Compared to Corresponding Changes in PaO2 Values. — 93.63 percentage of true positives