N/A N=24 Pilot Study of Navigational Bronchoscopy and Transthoracic Needle Biopsy
Peripheral Pulmonary Nodules
Primary: Feasibility — 24 participants
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=55 Robotic Bronchoscopy for Peripheral Pulmonary Lesions
Lung; Node
Primary: Number of Participants With Device or Procedure Related Adverse Events — 2 Participants
N/A N=200 Application of 3D Printing Technique in Small Pulmonary Nodule Localization
Lung Neoplasm · Thoracic Surgery, Video-Assisted
Primary: Accuracy of Lung Nodule Localization — 9.6; 8.7 mm
N/A N=258 Navigation Endoscopy to Reach Indeterminate Lung Nodules Versus Trans-Thoracic Needle Aspiration
Lung Nodule
Primary: Diagnostic Accuracy — 94; 81 Participants — p=0.003
N/A N=86 ENB-GS-TBLB for the Diagnosis of PPLs
Lung Cancer
Primary: The Difference of Diagnostic Value of ENB-GS-TBLB as Compared to GS-TBLB — 34; 25; 5; 16 participants — p=0.019
Phase 2 N=25 Percutaneous Image Guided Video-Assisted Thoracic Surgery (VATS) Resection of Lung Lesions
Lung Cancer
Primary: Number of Participants With Treatment-related Adverse Events as Assessed by CTCAE v4.0 — 1 Participants
N/A N=105 Piloting a Virtual Navigation (VN) System for Bronchoscopic Lung Nodule Sampling
Lung Cancer
Primary: Safety Measurement — 0; 0; 0; 0 Adverse events
N/A N=48 Comparative Study of Nonintubated Uniport Thoracoscopic Surgery Using Thoracic Paravertebral Nerve Block Versus Intercostal Nerve Block for Peripheral Solitary Pulmonary Nodule Patients
Peripheral Solitary Pulmonary Nodule or Tuberculoma
Primary: Comparing the Inflammatory Markers During the Operation After the Intervention of the Each Group — 33; 35; 39; 42 pg/L — p=0.025
Phase 2 N=98 Acetylsalicylic Acid Compared to Placebo in Treating High-Risk Patients With Subsolid Lung Nodules
Current Smoker · Former Smoker · Multiple Pulmonary Nodules
Primary: Change in the Sum of Longest Diameters of Baseline Target Nodules (Person-specific Analysis) — 0.3; -0.12 millimeter (mm)
N/A N=30 Clinical Description of a Bronchoscopic Approach to Ablate Lung Nodules Using the Emprint™ Ablation Catheter
Cancer, Lung · Cancer, Metastatic to Lung
Primary: Number of Participants With AEs Related to the Emprint™ Ablation Catheter Kit With Thermosphere™ Technology — 1 Participants
Phase 1 N=5 Feasibility Study of Using Navigational Bronchoscopy to Perform PDT-Photofrin® in Unresectable Peripheral Lung Cancer
Non-small Cell Lung Cancer (NSCLC) · Lung Metastasis
Primary: Feasibility to Perform Interstitial-Photodynamic Therapy (i-PDT) Into Tumor — 3; 0; 1; 1 Participants
N/A N=23 iNod System Human Feasibility Assessment
Solitary Pulmonary Nodule · Biopsy, Fine-Needle
Primary: Acquisition of Adequate Specimens of Targeted Lung Lesions — 9 Participants
N/A N=30 Feasibility of Performing Peripheral Pulmonary Lesion Biopsy Using Robotic Bronchoscopy-Guided Cryoprobe
Bronchi--Diseases · Lung Diseases, Obstructive · Lesions Mass
Primary: Ability to Successfully Obtain Sample — 123; 130 tissue samples
N/A N=50 Evaluation of the Lung Nodule Sensitivity of Stationary Chest Tomosynthesis in Patients With Known Lung Nodules
Signs and Symptoms
Primary: Sensitivity — 53 percentage of positive scans
Phase 2 N=15 18F-FSPG PET/CT in Diagnosing Early Lung Cancer in Patients With Lung Nodules
Cigarette Smoker · Current Smoker · Former Smoker
Primary: Diagnostic Performance Metrics (Sensitivity, Specificity, PPV, NPV, and Accuracy) of Ultrasonography and Capnography for Malignant Lung Nodules — 100; 70; 100; 100…
N/A N=30 InvestigatioN of a Smart Probe for Lung lEsion Characterization Using Impedance Technology
Lung Cancer
Primary: The Ability of BioSpy System to Acquire Electrophysiological Measurements in the Relevant Tissues During Bronchoscopic Biopsy. — 26 Participants
Phase 2 N=202 Budesonide in Treating Patients With Lung Nodules at High Risk of Developing Lung Cancer
Lung Cancer
Primary: Number CT- Detected Lung Nodules by Participant — 12; 14; 26; 19 lung nodules
Phase 2 N=40 Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study
Lung Non-Small Cell Carcinoma · Stage I Lung Cancer AJCC v8 · Stage IA1 Lung Cancer AJCC v8
Primary: 6-month CT Assessment (Tumor Response Per mRECIST) — 1; 36; 2; 1 Participants
N/A N=10 CrYobiopsy With Radial UltraSound Guidance
Pulmonary Disease
Primary: Time to Achieve Hemostasis After Obtaining Cryobiopsy — 146.55; 132.25 seconds — p=0.7878
Phase 1 N=10 Safety of PDT-Photofrin® Prior to Lung Surgery
Lung Cancer · Lung Cancer Metastatic
Primary: Safety: Number of Participants With at Least One Adverse Event — 10 Participants — p=<0.05
N/A N=1,200 Patient Navigation for Lung Screening at MGH Community Health Centers
Lung Cancer
Primary: Chest CT Completion — 124; 138 Participants
N/A N=25 Rehabilitation of Idiopathic Pulmonary Fibrosis (IPF) Patients
Idiopathic Pulmonary Fibrosis
Primary: 6 Minute Walk Distance — -6.2; -15.3 meters
N/A N=20 EBUS-Miniforceps Biopsy Specimen Acquisition for PD-L1 Testing in Nonsmall Cell Lung Cancer
Non Small Cell Lung Cancer · NSCLC
Primary: Feasibility of Utilizing Endobronchial Ultrasound Guided Miniforceps as Assessed by the Number of Participants From Whom Adequate Amounts of Tissue to Perform PD-L1…
N/A N=59 Mini Invasive Endomicroscopy of the Pleura for Malignancies Diagnosis
Pleural Diseases · Pleural Neoplasms
Primary: Malignant Pleural Infiltration Identification — 12; 27; 9; 4 Participants — p=0.023
N/A N=139 Non-Contrast 4DCT to Detect Pulmonary Thromboembolic Events
Pulmonary Thromboembolisms · Pulmonary Embolism
Primary: Correlation of 4DCT Identified Perfusion With SPECT/CT Identified Perfusion — 0.45 Spearman correlation
N/A N=12 Evaluation of Computer-Aided Lung Nodule Detection Software in Thoracic CT for Riverain Technologies LLC
Lung Cancer
Primary: Comparing the Detection Accuracy, Sensitivity, and Specificity of Clinically Actionable Lung Nodules — 3612; 3735; 1283; 1548 CT-case | nodule — p=<0.05
N/A N=78 Nitrous Oxide for Identifying the Intersegmental Plane in Segmentectomy: A Randomized Controlled Trial
Pulmonary Nodule, Solitary · Pulmonary Nodule, Multiple · Lung Cancer
Primary: The Intersegmental Border Appearance Time During the Surgery — 320.20; 552.39; 968.33 seconds
N/A N=25 EPIONE Guided Lung Evaluation
Lung Cancer
Primary: Feasibility of the Device — 26 Number of targets reached
Phase 2 N=100 OTL38 Injection for Intraoperative Imaging of Folate Receptor Positive Lung Nodules
Lung Neoplasms · Lung Cancer
Primary: Sensitivity or True Positive Rate (TPR) — 0.854 proportion of lesions
N/A N=131 Study of Cryoablation for Metastatic Lung Tumors
Neoplasm Metastasis
Primary: Local Tumor Control for Each Index Tumor as Measured by Imaging at Month 12 — 84.6 percentage of tumors — p=0.410