N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=49 Compare Anti-inflammatory Dentifrices
Gingivitis
Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05
Phase 3 N=23 Clinical Study to Evaluate Dental Plaque
Gingival Diseases
Primary: Dental Plaque Index — 2.48; 2.42 Units on a scale — p=0.05
N/A N=200 A Clinical Study to Evaluate Effects of an Oral Rinse on Plaque and Gingivitis
Plaque
Primary: Plaque Index Score Per Participant at 6 Months — 2.12; 2.70; 2.23; 2.84 score on a scale — p=<0.0001
Phase 3 N=19 Investigation of Dental Plaque and Gingival Index
Dental Plaque
Primary: Gingival Margin Plaque Index — 15.4; 12.81 Units on a scale — p=0.05
N/A N=56 Ability of Four Toothpastes to Remove Plaque
Dental Plaque
Primary: Mean Change From Baseline (Pre-brushing to Post-brushing) in Turesky Score After Single Supervised Use (Test Product 1 Versus [vs] Test Product 4) After 4 Weeks — 2.90…
Phase 1 N=24 A Plaque Test Study With LEO 35299 in Psoriasis Vulgaris
Psoriasis Vulgaris
Primary: Change in the Total Clinical Score From Baseline to Day 22 — -2.8; -1.9; -1.5; -1.8 units on a scale
Phase 3 N=32 Evaluate Dental Plaque Benefit of a Preventive Treatment Gel
Dental Plaque
Primary: Mean Turesky Modified Quigley-Hein Index at Day 4 — 1.83; 1.96 score on a scale
Phase 3 N=6 Effect on Bacterial Glycolytic Acid Formation on Plaque
Dental Plaque
Primary: ph of Dental Plaque After Sucrose Challenge — 4.88; 5.04; 4.98 ph of dental plaque — p=0.05
Phase 3 N=29 Clinical Study to Compare Dental Plaque Control
Dental Plaque
Primary: Dental Plaque Index — 3.12; 2.90; 2.92; 2.94 Units on a scale — p=<0.05
N/A N=1,271 The Lipid-Rich Plaque Study
Coronary Artery Disease · Atherosclerosis
Primary: Number of Participants Stratified as Non-Index Culprit Lesion Related Major Adverse Cardiac Events (NC-MACE) or No NC-MACE and Association With maxLCBI4mm as a…
Phase 4 N=135 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste
Dental Plaque · Gingivitis
Primary: Dental Plaque Score — 3.53; 3.55; 3.59 units on a scale — p=0.919
N/A N=50 Curved Soft-Picks on Plaque Accumulation on Patients With Gingivitis
Gingivitis
Primary: Change in Interproximal Plaque by Modification of the Quigley-Hein Plaque Index at 14 Days — 0.03; -0.07 score on a scale
Phase 2 N=23 Effect of a Commercial Cosmetic Mouth Rinse on Plaque Re-growth
Healthy Subjects
Primary: Plaque Index of Test Mouth Rinse Versus Sterile Water After Day 4 of Treatment Administration — 3.03; 3.23 Score on a scale — p=0.0915
Phase 4 N=217 Evaluate Carotid Artery Plaque Composition by Magnetic Resonance Imaging in People Receiving Cholesterol Medication
Coronary Artery Disease · Carotid Artery Diseases · Atherosclerosis
Primary: Annualized LRNC Volume Change in Carotid Plaque Composition, as Assessed by MRI — -4.6; -15.1; -9.4 mm^3/year
Phase 2 N=28 Evaluating Commercial Anti-Plaque Products and Oral Rinse
Dental Plaque
Primary: Plaque Index — 2.63; 2.65; 1.23 Units on a scale — p=0.05
N/A N=90 A Comparative Study of Electric Toothbrushes for the Efficacy Plaque Removal and the Effect on Plaque Accumulation and Gingivitis.
Dental Plaque Induced Gingivitis · Dental Plaque
Primary: Plaque Index — 1.07; 1.19; 1.31; 1.11 units on a scale — p=0.1561
Phase 3 N=22 Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse
Dental Plaque
Primary: Plaque Index — 3.31; 3.31; 2.91 Units on a scale — p=0.05
N/A N=56 Efficacy of Three Experimental Toothpastes to Remove Plaque
Dental Plaque
Primary: Change From Baseline (Pre-brushing) After a Single Brushing Treatment (Post-brushing) Turesky Modification of Quigley Hein Plaque Index (TPI), Positive Control Versus…
Phase 2 N=45 Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse
Dental Plaque · Dental Caries
Primary: Composite Plaque Score — 36.2; 37.9 score on a scale — p=.044
N/A N=80 Efficacy of Manual Toothbrushes in Removing Dental Plaque
Dental Plaque · Oral Hygiene
Primary: Change From Pre to Post Brushing in Overall Mean Rustogi Modified Navy Plaque Index (RPI) After a Single Brushing Event at Day 0 — -0.09623; -0.12005; -0.09859; -0.09599…
N/A N=42 Efficacy of Plaque Removal of a Novel Brushing Device
Dental Plaque
Primary: Change From Baseline in Dental Plaque Removal Efficacy Using Turesky Modification of the Quigley-Hein Plaque Index — 0.29; 0.6 units on a scale
Phase 2 N=24 A Psoriasis Plaque Test Study With LEO 90100 Cutaneous Spray, Ointment, in Psoriasis Vulgaris
Psoriasis Vulgaris
Primary: Absolute Change in Total Clinical Score (TCS) of Clinical Signs (Sum of Erythema, Scaling and Infiltration) at End of Treatment Compared to Baseline — -6.00; -4.96…
Phase 3 N=73 Clinical Research Study Efficacy of a Prototype Oral Rinse
Dental Plaque
Primary: Gingival Index — 1.90; 1.84 Units on a scale — p=0.005
Phase 2 N=27 Is an Antiplaque Chewing Gum (30 mg) Able to Reduce Dental Plaque in a Healthy Population?
Plaque Regrowth
Primary: Safety, Tolerability and Effectiveness in Reducing Dental Plaque of KLS-W Delivered in a Chewing Gum Formulation — 0; 0; 0; 0 participants
Phase 3 N=65 Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes
Dental Caries
Primary: Natural Log Transformed Area Under the Fluoride Concentration in Plaque Fluid by Time Curve (AUC) Between 0-4 Hours — 0.54; 0.54 ln(μg*F*minutes/cm^2) — p=0.9762
Phase 3 N=102 Compare the Clinical Efficacy of Prototype Toothpastes
Dental Plaque
Primary: Plaque Index — 0.91; 0.84; 1.77 Units on a scale — p=0.05
N/A N=258 The REVEALPLAQUE Study: A pRospEctiVe, multicEnter Study to AnaLyze PLAQUE Using CCTA
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
Primary: Comparison of Total Plaque Volume — 0.91 Pearson's correlation statistic
N/A N=43 Detection of Plaque Inflammation by Positron Emission Tomography (PET)-Effects of Simvastatin on Plaque Inflammation
Atherosclerosis
Primary: Plaque Inflammation — 1.59; 1.63 SUV
Phase 3 N=25 Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
Gingival Diseases
Primary: Plaque Index — 2.45; 2.22; 2.54; 2.56 Units on a scale — p=0.05