N/A N=26 Alvimopan and Ileus in PSF
Ileus · Spinal Fusion
Primary: Recovery of Bowel Function — 43.2; 34.0 Hours
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 1 N=41 Chewing Gum Use to Reduce Post-operative Ileus in Pediatric Patients
Post Operative Ileus
Primary: Post-Operative Hospital Stay — 79.93; 72.94 hours — p=0.665
Phase 4 N=65 Alvimopan as a Rescue Treatment of Postoperative Ileus
Ileus · Gastrointestinal Dysfunction
Primary: Hospital Length of Stay — 5; 6 days
Phase 3 N=524 Study of Intravenous (IV) Methylnaltrexone Bromide (MNTX) in the Treatment of Post-Operative Ileus (POI)
Post-Operative Ileus (POI)
Primary: Time to First Bowel Movement — 4.4; 4.8; 4.6 days — p=0.4259
Phase 4 N=97 Bowel Function After Minimally Invasive Hysterectomy
Constipation
Primary: Patient Assessment of Constipation Symptoms Questionnaire (PAC-SYM) Score — 1.1; 0.6 score
Phase 3 N=374 A Study Evaluating Intravenous (IV) MOA-728 for the Treatment of Postoperative Ileus (POI) in Participants After Ventral Hernia Repair
Ileus
Primary: Time to First Bowel Movement — 93.3; 100.4; 91.3 hours — p=0.944
Early Phase 1 N=66 Effects of Rocking on Postoperative Ileus Duration Study
Abdominal Cancer
Primary: Time to First Postoperative Flatus in Days Was the End of Postoperative Ileus (POI) Indicator. — 3.16; 3.88 Days — p=<0.05
Phase 2 N=112 A Study to Evaluate LB1148 for Return of Gastrointestinal Function and Adhesions in Subjects Undergoing Bowel Resection
Ileus · Post-Operative Adhesions
Primary: Change From Baseline in Extent and Severity of Intra-abdominal Adhesions Among Subjects Treated With LB1148 or Placebo — 20.3; 4.3; 4.0; 8.5 total extent and severity…
Phase 4 N=94 Oral Nutrition After Regular Radical Cystectomy
Post Cystostomy
Primary: the Postoperative Length of Stay — 18; 14 day — p=<0.001
N/A N=84 Effect of Preoperative Fiber on Postoperative Bowel Function
Constipation · Prolapse, Vaginal
Primary: Time to First Bowel Movement After Surgery — 66.5; 68.3 hours
Phase 2 N=82 Subcutaneous Methylnaltrexone Versus Placebo for Postoperative Ileus Prevention
Postoperative Ileus
Primary: Time to First Bowel Movement — 61.8; 50.7 hours — p=0.81
Phase 3 N=146 Accelerating Gastrointestinal Recovery
Ovarian Cancer · Fallopian Tube Cancer · Peritoneal Cancer
Primary: Postoperative Length of Hospital Stay — 4.4; 4.3 days — p=0.34
Phase 2 N=402 Safety and Efficacy of TU-100 as an Adjunct to an Enhanced Recovery After Surgery in Subjects Undergoing Bowel Resection
Enhanced Recovery After Surgery
Primary: Time to Gastrointestinal Recovery (GIR) — 32.6; 30.8; 33.4 hours — p=0.767
Phase 2 N=154 Post-Operative Constipation Following Total Knee Arthroplasty
Constipation
Primary: Bowel Movement (BM) Within 3 Days of Surgery — 29; 32 Participants — p=0.41
N/A N=203 Optimizing the Previs Device for Prediction of Postoperative Ileus
Ileus
Primary: Device Sensitivity for Predicting Ileus. — 12; 2; 22; 39 Participants
Phase 4 N=280 A Study of Alvimopan for the Management of Postoperative Ileus in Participants Undergoing Radical Cystectomy
Postoperative Ileus
Primary: Mean Time to Achieve GI2 Analyzed by Kaplan-Meier (KM) Estimates and Cox Proportional Hazards (PH) Model — 164.2; 132.7 Hours — p=<0.0001
N/A N=280 SANICS II Trial: Stimulation of the Autonomic Nervous System in Colorectal Surgery by Perioperative Nutrition
Postoperative Ileus · Anastomotic Leak
Primary: Number of Patients Developing Postoperative Ileus — 29; 37 Participants
N/A N=7,050 Clinical Outcomes After Bowel Resection in Patients Receiving Alvimopan Versus Patients Not Receiving Alvimopan in the Premier Perspective Database
Ileus
Primary: Percentage of Patients Who Died — 0.4; 1.0 Percent of participants — p=0.0007
N/A N=72 Bowel Function After Minimally Invasive Urogynecologic Surgery
Functional Disorder of Intestine
Primary: Time to First Post-op Bowel Movement — 64; 77 hours
N/A N=200 Postoperative Intermittent Intrauterine Balloon Dilatation Therapy.
Intrauterine Adhesion
Primary: Number of Participants With Adhesion Reformation (American Fertility Society Score of Greater Than 0) 8 Weeks Later After the Index Surgery — 21; 38 Participants — p=0.012
N/A N=77 Myoelectric Activity Following Colorectal Surgery and Return of Bowel Function
Gastrointestinal Diseases · Ileus Paralytic · Ileus
Primary: GI Functional Recovery — 47.94 hours
Phase 3 N=50 A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery
Postoperative Pain · Postoperative Nausea and Vomiting
Primary: Prevalence of Postoperative Gut Dysfunction — 13; 15 Participants — p=0.264
N/A N=198 Fast-track Rehabilitation After Elective Colorectal and Small Bowel Resection
Colorectal Tumor
Primary: the Length of Hospital Stay — 8; 7 day
Phase 4 N=71 Does a Preoperative Bowel Regimen Change Time to First Bowel Movement After Robotic Sacral Colpopexy
Constipation · Post-Op Complication
Primary: First Bowel Movement — 1.96; 2.32 days
N/A N=64 Lubiprostone (Amitiza®) Vs. Standard Care in Opioid-induced Constipation After Surgery in Inpatient Rehabilitation
Constipation
Primary: Change in Patient Assessment of Constipation (PAC) - Symptoms (Sym) — -0.22; -0.29 units on a scale — p=<0.05
Phase 4 N=120 Sugammadex To IMprove Bowel Function
Bowel Dysfunction · Postoperative Complications · Neuromuscular Blockade
Primary: Gastric Emptying — 1120; 1130 log(ng*ml-1)*min — p=0.58
Phase 4 N=56 B&O for TLH Post-operative Pain and Nausea
Hysterectomy · Pain, Postoperative
Primary: Post-operative Pain: VAS — 4.1; 4.8 score on a scale — p=0.17
N/A N=64 Gastrointestinal Activation Post-elective CS (Cesarean Section) :A Comparison of Paula Method to Standard Care
Bowel Dysfunction
Primary: Time to the Resumption of Bowel Functioning as Assessed by Flatus Passage — 24.1; 39.1 hours — p=<0.05
N/A N=84 Treatment for Acute Postoperative Voiding Dysfunction
Urinary Retention
Primary: Persistent Retention — 29; 21 participants
N/A N=100 Trial of Low Residue Diet Versus Clear Liquids Following Elective Colorectal Surgery
Nausea/Vomiting
Primary: Number of Participants Who Experienced Emesis on Post Operative Day 2 — 9; 9 Participants