Phase 4 N=16 Pathophysiology of Post Amputation Pain
Amputation Stumps · Neuroma
Primary: Change in Pain — -0.3; -2; -1; 1.3 units on a scale
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N/A N=16 Postoperative Peripheral Nerve Stimulation for Management of Post-amputation Pain
Phantom Limb Pain · Postoperative Pain · Neuroma
Primary: Average Phantom Limb Pain (PLP) Score — 4.1; 3.1; 2.2; 3.0 score on a scale
N/A N=14 Pulsed Electromagnetic Fields for Post-Amputation Pain
Phantom Limb Pain · Residual Limb Pain
Primary: Change in Average RESIDUAL Limb Pain Scores Between Baseline and Day 28 of the Initial Treatment as Measured With the Numeric Rating Scale — 2.5; 0 score on a scale
Phase 4 N=144 Treating Phantom Limb Pain Using Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study
Phantom Limb Pain
Primary: "Average" Phantom Limb Pain Intensity 4 Weeks Following Initiation of an Ambulatory Continuous Peripheral Nerve Block (as Measured by the Numeric Rating Scale Within the…
N/A N=10 AMP30: Autologous Fat Grafting, Amputation Sites Pain: Randomized
Wounded Warrior · Limb Shortening · Amputation
Primary: Efficacy of Autologous Fat Transfer at Pain Modulation at Respective Amputation Sites — 1.3; 0 score on a scale
N/A N=33 Electrical Stimulation for the Treatment of Post-Amputation Pain Using the SPRINT System
Post-Amputation Pain · Phantom Limb Pain · Residual Limb Pain
Primary: Proportion of Group 1 (Treatment) and Group 2 (Control) Subjects That Achieved ≥ 50% Reduction in All Qualifying Areas of Pain in the First 4 Weeks of Treatment — 7; 2…
N/A N=144 Cryoanalgesia to Treat Post-Amputation Phantom Limb Pain: A Department of Defense Funded Multicenter Study
Post-Amputation Phantom Limb Pain
Primary: Change From Baseline in Average Daily Phantom Pain Intensity — 0.5; 0 score on a scale
N/A N=12 Cryoanalgesia to Treat Phantom Limb Pain Following Above-Knee Amputation
Amputation, Surgical · Amputation, Traumatic · Phantom Limb Pain
Primary: Average Pain Intensity Change From Baseline 1 Month Post-intervention — 0; 0; 0 score on a scale
N/A N=423 Neuropathic Pain After Orchidectomy and Sex Reassignment Surgery
Neuropathic Pain · Phantom Pain · Sex Reassignment Surgery
Primary: Incidence of Phantom Pain — 6; 0 Participants — p=0.013
N/A N=4 Epidural Spinal Cord Stimulation for Sensory Restoration and Phantom Limb Pain in Upper-Limb Amputees
Phantom Limb
Primary: Stimulation Thresholds to a Variety of Stimulus Parameters — 2.13 milliamps
Phase 4 N=30 Peripheral Nerve Blocks for Above-the-knee Amputations
Peripheral Vascular Diseases · Hyperglycaemia (Diabetic) · Hypertension
Primary: Peripheral Nerve Block Success as a Primary Anesthetic — 1 Participants
Phase 2 N=128 Valproic Acid for the Prevention of Post-Amputation Pain
Pain, Phantom · Pain, Neuropathic
Primary: Number of Patients With Chronic Post-amputation Pain — 37; 36 Participants — p=0.53
N/A N=26 Surgical Treatment of Post-surgical Mastectomy Pain Utilizing the Regenerative Peripheral Nerve Interface
Post-Mastectomy Chronic Pain Syndrome
Primary: Change in Pain Level — 6.9; 0.6; 4.4; 2.5 score on a scale
Phase 3 N=140 Evaluation in the Treatment of Neuropathic Pain Post Breast Surgery
Breast Cancer Patient
Primary: Change in Neuropathic Pain Score at 2 Months (Numeric Rating Scale 0-10) — 4.1; 4.6 units on a scale
Phase 4 N=100 Single Shot Versus OnQ Pump in Extremity Fractures
Pain · Fracture
Primary: Change in Score on Visual Analog Scale (VAS) — 3.28; 1.47; 3.62; 3.91 score on a scale
N/A N=11 Mixed Reality Based System to Manage Phantom Pain Phantom Pain for Patients With Lower Limb Amputation
Phantom Limb Pain
Primary: Change in Numerical Rating Scale — 1.75; 1.125 score on a scale — p=0.011
N/A N=86 Pregabalin for the Treatment of Pain After Posterior Spinal Fusions
Lumbar Spinal Fusions
Primary: Patient Controlled Analgesia (PCA) Hydromorphone Usage — 44; 39 mL
N/A N=7 Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Analgesia
Postoperative Pain
Primary: Change From Baseline of Surgical Site Pain Level (NRS) at Rest [Percentage of Baseline Pain] — 64; 100; 55; 69 percentage of baseline
N/A N=147 Self-management to Improve Function Following Amputation
Amputation, Limb Loss
Primary: Short Musculoskeletal Function Assessment (SMFA) — 32.34; 30.19 score on a scale
N/A N=122 Percutaneous Auricular Neuromodulation for Postoperative Analgesia
Postoperative Pain, Acute
Primary: AVERAGE Pain Measured With the Numeric Rating Scale First 5 Postoperative Days — 1; 3 units on a scale
N/A N=80 Lidocaine 5% Patch (Lidoderm) for the Prevention of Acute and Chest Pain Following Robotic Valve Surgery
Perioperative Chest Pain
Primary: Pain Disability Index Score (PDI) at Six Months Following Surgical Procedure — 26; 30; 12; 13 units on a scale — p=0.28
N/A N=8 C-RFA of Residual Limb Neuroma
Phantom Limb Pain · Neuroma Amputation
Primary: Numeric Rating Scale (NRS) for Pain at 6 Months — 4 Participants
N/A N=65 Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Department of Defense Funded Multicenter Pilot Study
Rotator Cuff Repair · Anterior Cruciate Ligament Reconstruction · Ankle Arthrodesis or Arthroplasty
Primary: Opioid Consumption During First Postoperative Week — 5.0; 47.5 mg
Phase 4 N=14 Anesthesia for Pain After Ankle Fracture Surgery
Chronic Pain · Ankle Fracture Surgery · Regional Anesthesia
Primary: Pain Score at 12 Months - Experimental Group vs. Control Group — 36.33; 44.00 units on a scale — p=0.1269
N/A N=44 Strength, Pain and Function in Operation Iraqi Freedom/Operation Enduring Freedom Amputees: A Nurse-Managed Program
Traumatic Amputation
Primary: Lower Extremity Muscle Strength- Extension — 24.5; 26.4; 27.6; 34.1 Kilograms — p=<0.05
Phase 4 N=343 PAIN - Postoperative Analgesia INvestigation
Postoperative Pain
Primary: Postoperative Pain as Assessed by a Numeric Pain Scale (NPS) — 5.05; 5.02 units on a scale — p=0.934
Phase 4 N=68 Nicotine Patch as an Analgesic Adjuvant After Surgery
Pain
Primary: Postoperative Pain Score One Hour After Surgery — 5.78; 5.17; 4.32; 5.60 score on a scale
N/A N=402 Preventing Persistent Post-Surgical Pain and Dysfunction
Pain · Function · Anxiety
Primary: Pain Intensity — 4.1; 3.9; 3.9; 3.4 units on a scale
Phase 4 N=70 Perioperative Administration of Pregabalin for Pain After Mastectomy
Pain, Postoperative
Primary: Pain Scores (Verbal Numerical Rating Scale;VNRS) During Postoperative Hours. — 7; 5; 6; 5 Units on a scale
Early Phase 1 N=33 N-Acetyl-Cysteine (NAC) for Healing of Amputation Stumps in the Setting of Diabetes
Diabetes Mellitus · Critical Limb Ischemia · Lower Limb Amputation Knee
Primary: Change in Postoperative Laser-Assisted Fluorescent Angiography (LAFA) Perfusion. — 0.060; 0.096; 0.045; 0.031 percentage of defect