N/A N=60 Assesment of Post-stroke Elbow Flexor Spasticity in Different Forearm Positions
Post-stroke Elbow Spasticity
Primary: Dynamic Component of Spasticity (Spasticity Angle) — 70; 60; 57.5 degree — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=4 Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke Spasticity
Spasticity
Primary: Change From Baseline Contralesional Corticospinal Excitability — 67.88; -37.23 microVolts
Phase 3 N=109 Study Of GSK1358820 In Patients With Post-Stroke Upper Limb Spasticity
Post-Stroke Spasticity · Cerebrovascular Accident
Primary: Area Under the Curve (AUC) for the Change From Baseline in Modified Ashworth Scale (MAS) Wrist Score to the End of the DB Phase (Week 12) in the High-dose Groups…
N/A N=4 Treatment of Hand Dysfunction After Stroke
Stroke
Primary: Fugl-Meyer Upper Limb Coordination Scale (FMUE) — 27.75; 48.50 units on a scale — p=.0001
N/A N=67 Contralaterally Controlled FES of Arm & Hand for Subacute Stroke Rehabilitation
Stroke · Hemiparesis · Hemiplegia
Primary: Change in Box and Block Test (BBT) Score at 6 Months Post-Treatment — 13.5; 12.6; 9.6 blocks
N/A N=18 Botulinum Toxin as a Novel Treatment for Prevention of Post-Traumatic Elbow Stiffness
Post Traumatic Stiffness
Primary: Disabilities of the Arm, Shoulder, and Hand (DASH) Questionnaire — 27; 54 Scores on a Scale (0-100) — p=0.06
N/A N=34 Robotic Brace Incorporating Electromyography for Moderate Affected Arm Impairment After Stroke
Hemiparesis
Primary: Impairment in the Affected Upper Extremity as Measured by the Fugl Meyer Scale. — 19.6; 18.0; 17.6 units on a scale
N/A N=103 Patient Targeted Upper Extremity Rehabilitation After Stroke
Stroke
Primary: Fugl-Meyer Assessment of the Upper Extremity — 4.08; 2.45 score on a scale — p=0.912
N/A N=28 Electrical Stimulation for the Treatment of Post-Stroke Shoulder Pain
Shoulder Pain
Primary: Pain Intensity (Trial Stage) — 8.2; 6.1; 5.0; 2.1 score on a scale
N/A N=25 Electrical Stimulation for Hemiplegic Shoulder Pain
Stroke · Shoulder Pain
Primary: Brief Pain Inventory Short Form — 7.5; 7.6; 6.1; 6.8 units on a scale — p=0.04
Phase 3 N=317 Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Arm After a Stroke
Post-stroke Spasticity of the Upper Limb
Primary: Change From Baseline in Ashworth Scale (AS) Score of Primary Target Clinical Pattern — -0.9; -0.5 units on a scale — p=<0.001
Phase 2 N=26 The Role of Trans-spinal Direct Current Stimulation (tsDCS) in Treating Patients With Hand Spasticity After Stroke
Stroke · Cerebrovascular Accident (CVA) · Hemiparesis
Primary: Mean Percent Change From Baseline in Area Under the Curve for Objectively Measured Spastic Catch Response of the Wrist Flexors at Fast Speed — 13.678; -8.783; 15.927…
Phase 3 N=243 Dysport® Adult Upper Limb Spasticity
Nervous System Disorders
Primary: Change From Baseline in MAS Score in the Primary Targeted Muscle Group (PTMG) — -0.3; -1.2; -1.4 units on a scale
Phase 4 N=42 Study to Assess Impact of Dysport Injections Early After Stroke on Upper Limb Spasticity Progression
Stroke · Upper Limb Spasticity
Primary: Time Between the Initial Injection and the Appearance of Reinjection Criteria as Evaluated by the Modified Ashworth Scale (MAS) and Spasticity Symptoms — 156; 32 days…
N/A N=46 Treatment of Chronic Stroke With AMES + EMG Biofeedback
Stroke · Plegia · Paresis
Primary: Box and Blocks Test — 0.0; 0.5 Number of blocks moved — p=<0.005
N/A N=1 Effects of Post-Stroke Upper Extremity Assistance
Arm Weakness as a Consequence of Stroke
Primary: Wolf Motor Function Test - Change in Functional Score by Task (WMFT) — 7; 3; 5 Tasks
Phase 2 N=30 Post Stroke Hand Functions: Bilateral Movements and Electrical Stimulation Treatments
Cerebrovascular Accident · Hemiplegia
Primary: Box and Block Test; Data Collected = Number of Blocks Moved — 24.5; 24.6; 40; 27.5 Blocks — p=<0.05
N/A N=66 A Prospective Randomized Trial of Static-Progressive Versus Dynamic Splinting for Post-Traumatic Elbow Stiffness
Post-traumatic Stiff Elbows
Primary: Change in Arc of Flexion and Extension — 39; 40 Degrees
N/A N=31 Efficacy and Safety Study of Botulinum Neurotoxin A With Rehabilitation Versus Botulinum Neurotoxin A Alone in Treatment of Post-stroke Spasticity
Upper Limb Spasticity
Primary: The Maximum Change in Fugl-Meyer Upper Extremity Score From the Baseline Exam to Any Post Injection Visit in Each Treatment Arm. Comparison of the Difference Scores…
Phase 3 N=109 A Multicenter, Open-label, Single Dose Study of the Safety and Efficacy of GSK1358820 (Botulinum Toxin Type A) in Chinese Subjects With Post-stroke Focal Upper Limb Spasticity
Spasticity, Post-Stroke
Primary: Change From Baseline at Week 6 and Week 12 for Wrist Flexor Muscle Tone as Measured on the Modified Ashworth Scale (MAS) — -1.21; -1.33; -0.88; -1.12 scores on a scale…
N/A N=6 Effects of a Compliant Arm Support on Post-stroke Upper Extremity Range of Motion
Arm Weakness as a Consequence of Stroke
Primary: Percent Change From Baseline in Reachable Workspace — 27; -71 percent change
N/A N=122 Functional Electrical Stimulation (FES) for Upper Extremity Recovery in Stroke
Stroke, Acute · Stroke · Hemiparesis
Primary: Fugl-Meyer Motor Assessment (FMA) - Motor Impairment Measure — 27.5; 29.8; 26.8; 31.8 units on a scale — p=0.18
N/A N=14 Passive Tactile Stimulation for Stroke Rehabilitation
Stroke · Stroke, Ischemic · Stroke Hemorrhagic
Primary: Change in Modified Ashworth at 12 Weeks — 1.1 units on a scale — p=0.00025
N/A N=57 Objective Assessment of Upper Extremity Functioning of Stroke Patients Before and After Rehabilitation
Stroke
Primary: Fugl-Meyer Assessment. — 38.32; NA; 47.6; NA units on a scale
N/A N=23 Efficacy of Functional Electrical Stimulation (FES) in Persons Receiving Botulinum Neurotoxin for Upper Extremity Spasticity
Upper Extremity Spasticity · Stroke · Acquired Brain Injury
Primary: Change From Baseline in Arm Function Based on Motor Activities Log (MAL-O) — 1.52; 1.79 units on a scale
N/A N=96 Multimodal Treatment for Hemiplegic Shoulder Pain
Stroke · Shoulder Pain
Primary: Brief Pain Inventory (BPI)- Short Form (SF) Question 3 (BPI-SF3) - Mean Change From Baseline — 7.1; 7.4; 8.1; -2.8 units on a scale
Phase 3 N=468 BOTOX® Treatment in Adult Patients With Post-Stroke Lower Limb Spasticity
Muscle Spasticity
Primary: Change From Baseline in Modified Ashworth Scale-Bohannon (MAS-B) Score of Ankle Plantar Flexors Using a 6-Point Scale — 4.1; 4.1; -0.81; -0.61 Scores on a Scale
N/A N=24 Ipsihand Device Use in Stroke Patients to Assess Functional Motor Outcomes
Stroke
Primary: Fugl-Meyer Assessment - Upper Extremity — 9.18 Units on a scale
Phase 4 N=274 BOTOX® Economic Spasticity Trial (BEST)
Muscle Spasticity
Primary: Physician Assessment of Success, as Determined by Percentage of Patients Who Achieve Their Principal Active Functional Goal at Week 24 — 40.9; 33.3 Percentage of Patients
N/A N=132 Therapies for Recovery of Hand Function After Stroke
Stroke · Upper Extremity Paresis · Hemiplegia
Primary: Change in Box and Blocks Test (BBT) at 6 Months Post-Treatment — 5.1; 4.2; 3.0 blocks