Clinical Trial Search

Primary: Migraine Functional Impairment as Measured by Score on the Headache Impact Test 6 (HIT6) Scale — 59; 56 units on a scale

Primary: Headache Days as Self-reported by Participants — 3.0; 3.3 days

Primary: The Percentage of Subjects Reporting Pain Freedom at 60 Minutes Post-treatment — 50; 52.63 Percentage of responders

Primary: Persistent Headache Pain Free at 24 Hours — 26; 19 Participants

Primary: Pain Relief at 2 Hours During the First Migraine Attack Period — 246; 30; 74; 52 participants

Primary: The Number of Subjects With a Numeric Rating Scale Score (NRS) of Zero at Two Hours. — 5; 12 participants — p=0.03

Primary: Percentage of Subjects Reporting Headache Pain Freedom — 85; 14 Participants — p=<0.001

Primary: Percent Change of Headache Days Compared to Baseline — -13.50; -36.50 percent change of headache days

Primary: Headache Pain Relief at 2 hr Post-dose by 2-point Definition — 6; 11; 13 Participants

Primary: Number of Subjects With Pain Relief at 2 Hours From Time of First Dose — 136; 231 participants

Primary: Percentage of Subjects Achieving Headache Pain Freedom at Hour 2 — 43; 22 Participants — p=0.002

Primary: Number of Participants With Sustained Headache Relief Assessed by Self-evaluation — 40; 38 Participants

Primary: Change in MMD (Monthly Migraine Days) — -3.04; -2.14 migraine days per month

Primary: Pain Intensity Score — 4.7; 4.9; 5.3 scores on a scale

Primary: Change From Baseline in Mean Monthly Hours of at Least Moderate Headache Pain Intensity Over Months 1, 2, and 3 — -23.38; -31.33 hours/month — p=< 0.001

Primary: Percentage of Participants Who Are Headache Pain Free — 28.2; 32.2; 15.3 percentage of participants — p=<0.001

Primary: Migraine Frequency at 12 Weeks — -5.5; -3.9 days

Primary: Number of Participants With 2-hour Pain Free Active Study Drug — 35; 23; 21; 24 Participants — p=0.0038

Primary: Verbal Pain Score at 60 Minutes — 4.5; 4.9 units on a scale (0-10)

Primary: Change in Pain Scores From 0-30 Minutes on a Visual Analog Scale (VAS) — 1.38; 1.22 units on a scale — p=0.674

Primary: Adherence to Acute Migraine Management Strategies: Treat Early — 0; 2 Participants

Primary: Change in Number of Monthly Migraine Headache Days — -3.5; -1.1 migraine days

Primary: Percentage Decrease in Migraine Episodes — 48; 57; 46 Percentage decrease in migraine episodes — p=0.6207

Primary: Pain Freedom (PF) — 13; 4; 5; 16 Participants — p=<0.001

Primary: Pain-Relief at 2 Hours Post-treatment — 56; 65; 66 Participants

Primary: Headache Days — 23.64; 24.33 Days — p=0.83

Primary: Total Number of Responders — 17 Participants

Primary: Headache Pain Relief at 2 hr — 40; 62; 58; 68 Participants — p=0.0012

Primary: 30 Minute Pain Score — 3; 3; 3 score on a scale

Primary: Number of Participants Who Are Pain Free at 2 Hours Post-Dose — 61; 27 Participants